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Reviewed, UniProtKB/Swiss-Prot B7I451 (DCUP_ACIB5)

Last modified February 9, 2010. Version 11. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37
Gene names
Name: hemE
Ordered Locus Names: AB57_2800
OrganismAcinetobacter baumannii (strain AB0057) [Complete proteome] [HAMAP]
Taxonomic identifier480119 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

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Protein attributes

Sequence length357 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity. HAMAP MF_00218

Catalytic activity

Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218

Subunit structure

Homodimer By similarity. HAMAP MF_00218

Subcellular location

Cytoplasm By similarity HAMAP MF_00218.

Sequence similarities

Belongs to the uroporphyrinogen decarboxylase family.

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Ontologies

Keywords
   Biological processPorphyrin biosynthesis
   Cellular componentCytoplasm
   Molecular functionDecarboxylase
Lyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processporphyrin biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionuroporphyrinogen decarboxylase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 357357Uroporphyrinogen decarboxylase HAMAP MF_00218
PRO_1000197505

Regions

Region27 – 315Substrate binding By similarity

Sites

Binding site771Substrate By similarity
Binding site1541Substrate By similarity
Binding site2091Substrate By similarity
Binding site3301Substrate By similarity
Site771Transition state stabilizer By similarity

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Sequences

Sequence LengthMass (Da)Tools
B7I451-1 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 8BF84789C0A04F31

FASTA35739,409
        10         20         30         40         50         60 
MTTLKNDRFL RALLREPVDT TPIWMMRQAG RYLPEYRETR SKAGDFLSLC KNTEFACEVT 

        70         80         90        100        110        120 
LQPLRRYDLD AAILFSDILT IPDALGLGLY FETGEGPKFH KTVRTEQDVA NLPKLNAKAD 

       130        140        150        160        170        180 
LDYVMNAVST IRSALGGQVP LIGFSGSPWT LATYMVEGGS SKEFRFTKQM MYAQPEVLHA 

       190        200        210        220        230        240 
LLDHLADSVI DYLNAQIDAG AQAIQIFDSW GGALAHREYV EFSLNYMKKI IAGLQREKDG 

       250        260        270        280        290        300 
RRIPVIVFTK GGGQWLEPMI TTGADALGLD WTTPLNTART TVAGRVALQG NLDPAVLYGS 

       310        320        330        340        350 
AASIEKAVKA MLDDAYANGE KTGYVANLGH GITQWVDPAQ PKIFVDTVHE YSAKYLG

« Hide

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References

[1]"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii."
Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R.
J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001182 Genomic DNA. Translation: ACJ42150.1.
RefSeqYP_002320139.1.

3D structure databases

SMRB7I451. Positions 3-355.
ModBaseSearch...

Genome annotation databases

GeneID7046927.
GenomeReviewsGene locus AB57_2800 in contig CP001182_GR.
KEGGabn:AB57_2800.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG628392.
OMAQIFDTWG.

Family and domain databases

HAMAPMF_00218. URO-D.
[Tree]
InterProIPR006361. Uroporphyrinogen_deCO2ase_HemE.
IPR000257. Uroporphyrinogen_deCOase.
[Graphical view]
PANTHERPTHR21091:SF2. HemE. 1 hit.
PfamPF01208. URO-D. 1 hit.
[Graphical view]
TIGRFAMsTIGR01464. hemE. 1 hit.
PROSITEPS00906. UROD_1. 1 hit.
PS00907. UROD_2. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameDCUP_ACIB5
AccessionPrimary (citable) accession number: B7I451
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: February 9, 2010
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents