B7HZE3 (B7HZE3_BACC7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
GMP reductase HAMAP MF_01511
EC=1.7.1.7 HAMAP MF_01511

Alternative name(s):
Guanosine 5'-monophosphate oxidoreductase HAMAP MF_01511

Gene names

Name:	guaC HAMAP MF_01511 EMBL ACJ80136.1
Ordered Locus Names:	BCAH187_A5640

Organism

Bacillus cereus (strain AH187) [Complete proteome] [HAMAP]

Taxonomic identifier

405534 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	328 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides By similarity. HAMAP MF_01511 SAAS SAAS005994
Catalytic activity	Inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH. HAMAP MF_01511 SAAS SAAS005994
Sequence similarities	Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily. HAMAP MF_01511

Ontologies

Keywords
Ligand	NADP HAMAP MF_01511 SAAS SAAS005994
Molecular function	Oxidoreductase HAMAP MF_01511 SAAS SAAS005994 EMBL ACJ80136.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' pyrimidine base biosynthetic process Inferred from electronic annotation. Source: InterPro purine nucleotide metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	GMP reductase activity Inferred from electronic annotation. Source: HAMAP dihydroorotate dehydrogenase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	205 – 228	24	NADP By similarity HAMAP MF_01511
Sites
	Active site	176	1	Thioimidate intermediate By similarity HAMAP MF_01511

Sequences

	Sequence		Length	Mass (Da)
	B7HZE3 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: E1FFA9B8CCBCDAA0	FASTA	328	36,244
	10 20 30 40 50 60 MMENVFDYED IQLIPAKCIV NSRSECDTTV TLGKHKFKLP VVPANMQTII DERIATYLAE 70 80 90 100 110 120 NNYFYIMHRF QPEKRISFIR DMQSRGLIAS ISVGVKADEY EFVQQLAAEH LTPEYITIDI 130 140 150 160 170 180 AHGHSNAVIN MIQHIKKHLP ESFVIAGNVG TPEAVRELEN AGADATKVGI GPGKVCITKI 190 200 210 220 230 240 KTGFGTGGWQ LAALRWCAKA ASKPIIADGG IRTHGDVAKS IRFGATMVMI GSLFAGHEES 250 260 270 280 290 300 PGETIEKDGK LYKEYFGSAS EFQKGEKKNV EGKKMFVEHK GSLEDTLIEM EQDLQSSISY 310 320 AGGTKLDSIR TVDYVVVKNS IFNGDKVY

References

[1]	"Genome sequence of Bacillus cereus AH187." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001177 Genomic DNA. Translation: ACJ80136.1.
RefSeq	YP_002341527.1. NC_011658.1.
3D structure databases
ProteinModelPortal	B7HZE3.
ModBase	Search...
Protein-protein interaction databases
STRING	B7HZE3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000093986; EBBACP00000088580; EBBACG00000093979.
GeneID	7074769.
GenomeReviews	Gene locus BCAH187_A5640 in contig CP001177_GR.
KEGG	bcr:BCAH187_A5640.
PATRIC	18836699. VBIBacCer120511_5792.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000000995.
HOGENOM	HBG298985.
OMA	PDYITID.
ProtClustDB	PRK05458.
Family and domain databases
HAMAP	MF_01511. GMP_reduct_type2. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR001295. Dihydroorotate_DH_CS. IPR005994. GMP_reduct2. IPR015875. IMP_DH/GMP_Rdtase_CS. IPR001093. IMP_DH_GMPRt. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K00364.
PANTHER	PTHR11911:SF30. PTHR11911:SF30. 1 hit.
Pfam	PF00478. IMPDH. 1 hit. [Graphical view]
PIRSF	PIRSF036500. GMP_red_Firmic. 1 hit.
TIGRFAMs	TIGR01306. GMP_reduct_2. 1 hit.
PROSITE	PS00912. DHODEHASE_2. 1 hit. PS00487. IMP_DH_GMP_RED. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7HZE3_BACC7

Accession

Primary (citable) accession number: B7HZE3

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 20 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)