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B7HYD0

- B7HYD0_BACC7

UniProt

B7HYD0 - B7HYD0_BACC7

Protein

Polyamine aminopropyl transferase

Gene

speE

Organism
Bacillus cereus (strain AH187)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation

    Catalytic activityi

    S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei7 – 71PolyamineUniRule annotation
    Binding sitei31 – 311S-adenosylmethioninamineUniRule annotation
    Binding sitei62 – 621PolyamineUniRule annotation
    Binding sitei86 – 861PolyamineUniRule annotation
    Binding sitei106 – 1061S-adenosylmethioninamineUniRule annotation
    Active sitei155 – 1551Proton acceptorUniRule annotation
    Binding sitei162 – 1621S-adenosylmethioninamine; via carbonyl oxygenUniRule annotation

    GO - Molecular functioni

    1. spermidine synthase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. spermidine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    TransferaseUniRule annotationImported

    Keywords - Biological processi

    Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciBCER405534:GHXM-5472-MONOMER.
    UniPathwayiUPA00248; UER00314.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Polyamine aminopropyl transferaseUniRule annotation
    Alternative name(s):
    Putrescine aminopropyltransferaseUniRule annotation
    Spermidine synthaseUniRule annotation
    Gene namesi
    Name:speEUniRule annotationImported
    Ordered Locus Names:BCAH187_A5548Imported
    OrganismiBacillus cereus (strain AH187)Imported
    Taxonomic identifieri405534 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002214: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405534.BCAH187_A5548.

    Structurei

    3D structure databases

    ProteinModelPortaliB7HYD0.
    SMRiB7HYD0. Positions 2-274.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 235234PABSUniRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni137 – 1382S-adenosylmethioninamine bindingUniRule annotation
    Regioni156 – 1583Polyamine bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the spermidine/spermine synthase family.UniRule annotation
    Contains 1 PABS (polyamine biosynthesis) domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0421.
    HOGENOMiHOG000256146.
    KOiK00797.
    OMAiCKTLFPV.
    OrthoDBiEOG644ZMH.

    Family and domain databases

    Gene3Di3.40.50.150. 1 hit.
    HAMAPiMF_00198. Spermidine_synth.
    InterProiIPR029063. SAM-dependent_MTases-like.
    IPR001045. Spermidine/spermine_synthase.
    [Graphical view]
    PANTHERiPTHR11558. PTHR11558. 1 hit.
    PfamiPF01564. Spermine_synth. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 1 hit.
    TIGRFAMsiTIGR00417. speE. 1 hit.
    PROSITEiPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
    PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7HYD0-1 [UniParc]FASTAAdd to Basket

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    MELWFTEKQT KHFGITARIN RTLHTEQTEF QKLDMVETEE FGNMLILDGM    50
    VMTTEKDEFV YHEMVAHVPL FTHPNPENVL VVGGGDGGVI REVLKHPSVK 100
    KATLVEIDGK VIEYSKQYLP SIAGALDNER VEVKVGDGFL HIAESENEYD 150
    VIMVDSTEPV GPAVNLFTKG FYAGISKALK EDGIFVAQTD NPWFTPELIT 200
    TVFKDVKEIF PITRLYTANI PTYPSGLWTF TIGSKKHDPL EVSEERFHEI 250
    ETKYYTKELH NAAFALPKFV GDLIK 275
    Length:275
    Mass (Da):31,144
    Last modified:February 10, 2009 - v1
    Checksum:iD4752C642BD883AD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ79756.1.
    RefSeqiYP_002341437.1. NC_011658.1.

    Genome annotation databases

    EnsemblBacteriaiACJ79756; ACJ79756; BCAH187_A5548.
    GeneIDi7075725.
    KEGGibcr:BCAH187_A5548.
    PATRICi18836521. VBIBacCer120511_5703.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ79756.1 .
    RefSeqi YP_002341437.1. NC_011658.1.

    3D structure databases

    ProteinModelPortali B7HYD0.
    SMRi B7HYD0. Positions 2-274.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405534.BCAH187_A5548.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ79756 ; ACJ79756 ; BCAH187_A5548 .
    GeneIDi 7075725.
    KEGGi bcr:BCAH187_A5548.
    PATRICi 18836521. VBIBacCer120511_5703.

    Phylogenomic databases

    eggNOGi COG0421.
    HOGENOMi HOG000256146.
    KOi K00797.
    OMAi CKTLFPV.
    OrthoDBi EOG644ZMH.

    Enzyme and pathway databases

    UniPathwayi UPA00248 ; UER00314 .
    BioCyci BCER405534:GHXM-5472-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 1 hit.
    HAMAPi MF_00198. Spermidine_synth.
    InterProi IPR029063. SAM-dependent_MTases-like.
    IPR001045. Spermidine/spermine_synthase.
    [Graphical view ]
    PANTHERi PTHR11558. PTHR11558. 1 hit.
    Pfami PF01564. Spermine_synth. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 1 hit.
    TIGRFAMsi TIGR00417. speE. 1 hit.
    PROSITEi PS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
    PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus AH187."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AH187Imported.

    Entry informationi

    Entry nameiB7HYD0_BACC7
    AccessioniPrimary (citable) accession number: B7HYD0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 10, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3