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B7HYD0

- B7HYD0_BACC7

UniProt

B7HYD0 - B7HYD0_BACC7

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Protein
Polyamine aminopropyl transferase
Gene
speE, BCAH187_A5548
Organism
Bacillus cereus (strain AH187)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine By similarity.UniRule annotation

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71Polyamine By similarityUniRule annotation
Binding sitei31 – 311S-adenosylmethioninamine By similarityUniRule annotation
Binding sitei62 – 621Polyamine By similarityUniRule annotation
Binding sitei86 – 861Polyamine By similarityUniRule annotation
Binding sitei106 – 1061S-adenosylmethioninamine By similarityUniRule annotation
Active sitei155 – 1551Proton acceptor By similarityUniRule annotation
Binding sitei162 – 1621S-adenosylmethioninamine; via carbonyl oxygen By similarityUniRule annotation

GO - Molecular functioni

  1. spermidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotationImported

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciBCER405534:GHXM-5472-MONOMER.
UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine aminopropyl transferaseUniRule annotation
Alternative name(s):
Putrescine aminopropyltransferase
Spermidine synthase
Gene namesi
Name:speEUniRule annotationImported
Ordered Locus Names:BCAH187_A5548Imported
OrganismiBacillus cereus (strain AH187)Imported
Taxonomic identifieri405534 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002214: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405534.BCAH187_A5548.

Structurei

3D structure databases

ProteinModelPortaliB7HYD0.
SMRiB7HYD0. Positions 2-274.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 235234PABS By similarityUniRule annotation
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1382S-adenosylmethioninamine binding By similarityUniRule annotation
Regioni156 – 1583Polyamine binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0421.
HOGENOMiHOG000256146.
KOiK00797.
OMAiCKTLFPV.
OrthoDBiEOG644ZMH.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00198. Spermidine_synth.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERiPTHR11558. PTHR11558. 1 hit.
PfamiPF01564. Spermine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7HYD0-1 [UniParc]FASTAAdd to Basket

« Hide

MELWFTEKQT KHFGITARIN RTLHTEQTEF QKLDMVETEE FGNMLILDGM    50
VMTTEKDEFV YHEMVAHVPL FTHPNPENVL VVGGGDGGVI REVLKHPSVK 100
KATLVEIDGK VIEYSKQYLP SIAGALDNER VEVKVGDGFL HIAESENEYD 150
VIMVDSTEPV GPAVNLFTKG FYAGISKALK EDGIFVAQTD NPWFTPELIT 200
TVFKDVKEIF PITRLYTANI PTYPSGLWTF TIGSKKHDPL EVSEERFHEI 250
ETKYYTKELH NAAFALPKFV GDLIK 275
Length:275
Mass (Da):31,144
Last modified:February 10, 2009 - v1
Checksum:iD4752C642BD883AD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001177 Genomic DNA. Translation: ACJ79756.1.
RefSeqiYP_002341437.1. NC_011658.1.

Genome annotation databases

EnsemblBacteriaiACJ79756; ACJ79756; BCAH187_A5548.
GeneIDi7075725.
KEGGibcr:BCAH187_A5548.
PATRICi18836521. VBIBacCer120511_5703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001177 Genomic DNA. Translation: ACJ79756.1 .
RefSeqi YP_002341437.1. NC_011658.1.

3D structure databases

ProteinModelPortali B7HYD0.
SMRi B7HYD0. Positions 2-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405534.BCAH187_A5548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ79756 ; ACJ79756 ; BCAH187_A5548 .
GeneIDi 7075725.
KEGGi bcr:BCAH187_A5548.
PATRICi 18836521. VBIBacCer120511_5703.

Phylogenomic databases

eggNOGi COG0421.
HOGENOMi HOG000256146.
KOi K00797.
OMAi CKTLFPV.
OrthoDBi EOG644ZMH.

Enzyme and pathway databases

UniPathwayi UPA00248 ; UER00314 .
BioCyci BCER405534:GHXM-5472-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_00198. Spermidine_synth.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view ]
PANTHERi PTHR11558. PTHR11558. 1 hit.
Pfami PF01564. Spermine_synth. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00417. speE. 1 hit.
PROSITEi PS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus AH187."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AH187Imported.

Entry informationi

Entry nameiB7HYD0_BACC7
AccessioniPrimary (citable) accession number: B7HYD0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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