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B7HYD0

- B7HYD0_BACC7

UniProt

B7HYD0 - B7HYD0_BACC7

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Protein

Polyamine aminopropyl transferase

Gene

speE

Organism
Bacillus cereus (strain AH187)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei7 – 71PolyamineUniRule annotation
Binding sitei31 – 311S-adenosylmethioninamineUniRule annotation
Binding sitei62 – 621PolyamineUniRule annotation
Binding sitei86 – 861PolyamineUniRule annotation
Binding sitei106 – 1061S-adenosylmethioninamineUniRule annotation
Active sitei155 – 1551Proton acceptorUniRule annotation
Binding sitei162 – 1621S-adenosylmethioninamine; via carbonyl oxygenUniRule annotation

GO - Molecular functioni

  1. spermidine synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

TransferaseUniRule annotation

Keywords - Biological processi

Polyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciBCER405534:GHXM-5472-MONOMER.
UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine aminopropyl transferaseUniRule annotation
Alternative name(s):
Putrescine aminopropyltransferaseUniRule annotation
Spermidine synthaseUniRule annotation
Gene namesi
Name:speEUniRule annotationImported
Ordered Locus Names:BCAH187_A5548Imported
OrganismiBacillus cereus (strain AH187)Imported
Taxonomic identifieri405534 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000002214: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi405534.BCAH187_A5548.

Structurei

3D structure databases

ProteinModelPortaliB7HYD0.
SMRiB7HYD0. Positions 2-274.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 235234PABSUniRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni137 – 1382S-adenosylmethioninamine bindingUniRule annotation
Regioni156 – 1583Polyamine bindingUniRule annotation

Sequence similaritiesi

Belongs to the spermidine/spermine synthase family.UniRule annotation
Contains 1 PABS (polyamine biosynthesis) domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0421.
HOGENOMiHOG000256146.
KOiK00797.
OMAiCKTLFPV.
OrthoDBiEOG644ZMH.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00198. Spermidine_synth.
InterProiIPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERiPTHR11558. PTHR11558. 1 hit.
PfamiPF01564. Spermine_synth. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7HYD0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MELWFTEKQT KHFGITARIN RTLHTEQTEF QKLDMVETEE FGNMLILDGM
60 70 80 90 100
VMTTEKDEFV YHEMVAHVPL FTHPNPENVL VVGGGDGGVI REVLKHPSVK
110 120 130 140 150
KATLVEIDGK VIEYSKQYLP SIAGALDNER VEVKVGDGFL HIAESENEYD
160 170 180 190 200
VIMVDSTEPV GPAVNLFTKG FYAGISKALK EDGIFVAQTD NPWFTPELIT
210 220 230 240 250
TVFKDVKEIF PITRLYTANI PTYPSGLWTF TIGSKKHDPL EVSEERFHEI
260 270
ETKYYTKELH NAAFALPKFV GDLIK
Length:275
Mass (Da):31,144
Last modified:February 10, 2009 - v1
Checksum:iD4752C642BD883AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001177 Genomic DNA. Translation: ACJ79756.1.
RefSeqiYP_002341437.1. NC_011658.1.

Genome annotation databases

EnsemblBacteriaiACJ79756; ACJ79756; BCAH187_A5548.
GeneIDi7075725.
KEGGibcr:BCAH187_A5548.
PATRICi18836521. VBIBacCer120511_5703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001177 Genomic DNA. Translation: ACJ79756.1 .
RefSeqi YP_002341437.1. NC_011658.1.

3D structure databases

ProteinModelPortali B7HYD0.
SMRi B7HYD0. Positions 2-274.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405534.BCAH187_A5548.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ79756 ; ACJ79756 ; BCAH187_A5548 .
GeneIDi 7075725.
KEGGi bcr:BCAH187_A5548.
PATRICi 18836521. VBIBacCer120511_5703.

Phylogenomic databases

eggNOGi COG0421.
HOGENOMi HOG000256146.
KOi K00797.
OMAi CKTLFPV.
OrthoDBi EOG644ZMH.

Enzyme and pathway databases

UniPathwayi UPA00248 ; UER00314 .
BioCyci BCER405534:GHXM-5472-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 1 hit.
HAMAPi MF_00198. Spermidine_synth.
InterProi IPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view ]
PANTHERi PTHR11558. PTHR11558. 1 hit.
Pfami PF01564. Spermine_synth. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 1 hit.
TIGRFAMsi TIGR00417. speE. 1 hit.
PROSITEi PS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus AH187."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AH187Imported.

Entry informationi

Entry nameiB7HYD0_BACC7
AccessioniPrimary (citable) accession number: B7HYD0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3