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Protein

Polyamine aminopropyltransferase

Gene

speE

Organism
Bacillus cereus (strain AH187)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.UniRule annotation

Catalytic activityi

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine.UniRule annotation

Pathwayi: spermidine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes spermidine from putrescine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Polyamine aminopropyltransferase (speE), Polyamine aminopropyltransferase (speE)
This subpathway is part of the pathway spermidine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes spermidine from putrescine, the pathway spermidine biosynthesis and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei7PolyamineUniRule annotation1
Binding sitei31S-adenosylmethioninamineUniRule annotation1
Binding sitei62PolyamineUniRule annotation1
Binding sitei86PolyamineUniRule annotation1
Binding sitei106S-adenosylmethioninamineUniRule annotation1
Active sitei155Proton acceptorUniRule annotation1
Binding sitei162S-adenosylmethioninamine; via carbonyl oxygenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferaseUniRule annotationImported
Biological processPolyamine biosynthesisUniRule annotation, Spermidine biosynthesisUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00248; UER00314.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyamine aminopropyltransferaseUniRule annotation
Alternative name(s):
Putrescine aminopropyltransferaseUniRule annotation
Short name:
PAPTUniRule annotation
Spermidine synthaseUniRule annotation (EC:2.5.1.16UniRule annotation)
Short name:
SPDSUniRule annotation
Short name:
SPDSYUniRule annotation
Gene namesi
Name:speEUniRule annotationImported
Ordered Locus Names:BCAH187_A5548Imported
OrganismiBacillus cereus (strain AH187)Imported
Taxonomic identifieri405534 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002214 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm SAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmSAAS annotation

Interactioni

Subunit structurei

Homodimer or homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7HYD0.
SMRiB7HYD0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 235PABSInterPro annotationAdd BLAST234

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni137 – 138S-adenosylmethioninamine bindingUniRule annotation2
Regioni156 – 158Polyamine bindingUniRule annotation3

Sequence similaritiesi

Belongs to the spermidine/spermine synthase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000256146.
KOiK00797.
OMAiHEMVAHP.

Family and domain databases

Gene3Di2.30.140.10. 1 hit.
HAMAPiMF_00198. Spermidine_synth. 1 hit.
InterProiView protein in InterPro
IPR030374. PABS.
IPR030373. PABS_CS.
IPR029063. SAM-dependent_MTases.
IPR001045. Spermi_synthase.
IPR035246. Spermidine_synt_N.
IPR037163. Spermidine_synt_N_sf.
PfamiView protein in Pfam
PF17284. Spermine_synt_N. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00417. speE. 1 hit.
PROSITEiView protein in PROSITE
PS01330. PABS_1. 1 hit.
PS51006. PABS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B7HYD0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELWFTEKQT KHFGITARIN RTLHTEQTEF QKLDMVETEE FGNMLILDGM
60 70 80 90 100
VMTTEKDEFV YHEMVAHVPL FTHPNPENVL VVGGGDGGVI REVLKHPSVK
110 120 130 140 150
KATLVEIDGK VIEYSKQYLP SIAGALDNER VEVKVGDGFL HIAESENEYD
160 170 180 190 200
VIMVDSTEPV GPAVNLFTKG FYAGISKALK EDGIFVAQTD NPWFTPELIT
210 220 230 240 250
TVFKDVKEIF PITRLYTANI PTYPSGLWTF TIGSKKHDPL EVSEERFHEI
260 270
ETKYYTKELH NAAFALPKFV GDLIK
Length:275
Mass (Da):31,144
Last modified:February 10, 2009 - v1
Checksum:iD4752C642BD883AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001177 Genomic DNA. Translation: ACJ79756.1.
RefSeqiWP_000424696.1. NC_011658.1.

Genome annotation databases

EnsemblBacteriaiACJ79756; ACJ79756; BCAH187_A5548.
GeneIDi31627095.
KEGGibcr:BCAH187_A5548.

Similar proteinsi

Entry informationi

Entry nameiB7HYD0_BACC7
AccessioniPrimary (citable) accession number: B7HYD0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Keywords - Technical termi

Complete proteomeImported