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B7HYD0 (B7HYD0_BACC7) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 39. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Spermidine synthase RuleBase RU003837 HAMAP-Rule MF_00198

EC=2.5.1.16 RuleBase RU003837 HAMAP-Rule MF_00198
Alternative name(s):
Putrescine aminopropyltransferase HAMAP-Rule MF_00198
SPDSY HAMAP-Rule MF_00198
Gene names
Name:speE HAMAP-Rule MF_00198 EMBL ACJ79756.1
Ordered Locus Names:BCAH187_A5548 EMBL ACJ79756.1
OrganismBacillus cereus (strain AH187) [Complete proteome] [HAMAP] EMBL ACJ79756.1
Taxonomic identifier405534 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group

Protein attributes

Sequence length275 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor By similarity. HAMAP-Rule MF_00198

Catalytic activity

S-adenosyl 3-(methylthio)propylamine + putrescine = 5'-S-methyl-5'-thioadenosine + spermidine. RuleBase RU003837 HAMAP-Rule MF_00198

Pathway

Amine and polyamine biosynthesis; spermidine biosynthesis; spermidine from putrescine: step 1/1. HAMAP-Rule MF_00198

Subunit structure

Homodimer or homotetramer By similarity. HAMAP-Rule MF_00198

Sequence similarities

Belongs to the spermidine/spermine synthase family. RuleBase RU003836 HAMAP-Rule MF_00198

Contains 1 PABS (polyamine biosynthesis) domain. HAMAP-Rule MF_00198

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain2 – 235234PABS By similarity HAMAP-Rule MF_00198
Region137 – 1382S-adenosylmethioninamine binding By similarity HAMAP-Rule MF_00198

Sites

Active site1551Proton acceptor By similarity HAMAP-Rule MF_00198
Binding site311S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site611Putrescine By similarity HAMAP-Rule MF_00198
Binding site861S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site1061S-adenosylmethioninamine By similarity HAMAP-Rule MF_00198
Binding site1581Putrescine By similarity HAMAP-Rule MF_00198
Binding site2231Putrescine By similarity HAMAP-Rule MF_00198

Sequences

Sequence LengthMass (Da)Tools
B7HYD0 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: D4752C642BD883AD

FASTA27531,144
        10         20         30         40         50         60 
MELWFTEKQT KHFGITARIN RTLHTEQTEF QKLDMVETEE FGNMLILDGM VMTTEKDEFV 

        70         80         90        100        110        120 
YHEMVAHVPL FTHPNPENVL VVGGGDGGVI REVLKHPSVK KATLVEIDGK VIEYSKQYLP 

       130        140        150        160        170        180 
SIAGALDNER VEVKVGDGFL HIAESENEYD VIMVDSTEPV GPAVNLFTKG FYAGISKALK 

       190        200        210        220        230        240 
EDGIFVAQTD NPWFTPELIT TVFKDVKEIF PITRLYTANI PTYPSGLWTF TIGSKKHDPL 

       250        260        270 
EVSEERFHEI ETKYYTKELH NAAFALPKFV GDLIK 

« Hide

References

[1]"Genome sequence of Bacillus cereus AH187."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AH187 EMBL ACJ79756.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001177 Genomic DNA. Translation: ACJ79756.1.
RefSeqYP_002341437.1. NC_011658.1.

3D structure databases

ProteinModelPortalB7HYD0.
SMRB7HYD0. Positions 2-274.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING405534.BCAH187_A5548.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ79756; ACJ79756; BCAH187_A5548.
GeneID7075725.
KEGGbcr:BCAH187_A5548.
PATRIC18836521. VBIBacCer120511_5703.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0421.
HOGENOMHOG000256146.
KOK00797.
OMACKTLFPV.
OrthoDBEOG644ZMH.

Enzyme and pathway databases

BioCycBCER405534:GHXM-5472-MONOMER.
UniPathwayUPA00248; UER00314.

Family and domain databases

Gene3D3.40.50.150. 1 hit.
HAMAPMF_00198. Spermidine_synth.
InterProIPR029063. SAM-dependent_MTases-like.
IPR001045. Spermidine/spermine_synthase.
[Graphical view]
PANTHERPTHR11558. PTHR11558. 1 hit.
PfamPF01564. Spermine_synth. 1 hit.
[Graphical view]
SUPFAMSSF53335. SSF53335. 1 hit.
TIGRFAMsTIGR00417. speE. 1 hit.
PROSITEPS01330. SPERMIDINE_SYNTHASE_1. 1 hit.
PS51006. SPERMIDINE_SYNTHASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB7HYD0_BACC7
AccessionPrimary (citable) accession number: B7HYD0
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)