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B7HWU2

- ARSC_BACC7

UniProt

B7HWU2 - ARSC_BACC7

Protein

Protein ArsC

Gene

arsC

Organism
Bacillus cereus (strain AH187)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Reduces arsenate [As(V)] to arsenite [As(III)] and dephosphorylates tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates. Could switch between different functions in different circumstances.UniRule annotation

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.UniRule annotation
    Arsenate + thioredoxin = arsenite + thioredoxin disulfide + H2O.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei11 – 111Nucleophile; for reductase activity and phosphatase activityUniRule annotation
    Active sitei83 – 831Nucleophile; for reductase activityUniRule annotation
    Active sitei90 – 901Nucleophile; for reductase activityUniRule annotation

    GO - Molecular functioni

    1. arsenate reductase (thioredoxin) activity Source: UniProtKB-HAMAP
    2. protein tyrosine phosphatase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. response to arsenic-containing substance Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Oxidoreductase

    Keywords - Biological processi

    Arsenical resistance

    Enzyme and pathway databases

    BioCyciBCER405534:GHXM-3170-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein ArsCUniRule annotation
    Alternative name(s):
    Arsenate reductaseUniRule annotation (EC:1.20.4.-UniRule annotation)
    Arsenical pump modifierUniRule annotation
    Low molecular weight protein-tyrosine-phosphataseUniRule annotation (EC:3.1.3.48UniRule annotation)
    Gene namesi
    Name:arsCUniRule annotation
    Ordered Locus Names:BCAH187_A3221
    OrganismiBacillus cereus (strain AH187)
    Taxonomic identifieri405534 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002214: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 134134Protein ArsCPRO_1000186117Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi11 ↔ 83Redox-active; alternateUniRule annotation
    Disulfide bondi83 ↔ 90Redox-active; alternateUniRule annotation

    Keywords - PTMi

    Disulfide bond

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405534.BCAH187_A3221.

    Structurei

    3D structure databases

    ProteinModelPortaliB7HWU2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the low molecular weight phosphotyrosine protein phosphatase superfamily. ArsC family.UniRule annotation

    Keywords - Domaini

    Redox-active center

    Phylogenomic databases

    eggNOGiCOG0394.
    HOGENOMiHOG000273093.
    KOiK03741.
    OMAiGDRYEAY.
    OrthoDBiEOG6JDWJC.

    Family and domain databases

    HAMAPiMF_01624. Arsenate_reduct.
    InterProiIPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view]
    PANTHERiPTHR11717. PTHR11717. 1 hit.
    PfamiPF01451. LMWPc. 1 hit.
    [Graphical view]
    SMARTiSM00226. LMWPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52788. SSF52788. 1 hit.
    TIGRFAMsiTIGR02691. arsC_pI258_fam. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7HWU2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MENKKTIYFL CTGNSCRSQM AEAWGKKYLG DNWNVYSAGI EAHGVNPNAI    50
    KAMNEVNIDI TNQTSDIIDA NILNRADLVV TLCSHADSVC PSTPPDVNRV 100
    HWGFDDPAGK EWSEFQRVRD EIGERIKRFS ETGE 134
    Length:134
    Mass (Da):15,036
    Last modified:February 10, 2009 - v1
    Checksum:iD7E2A5C42948221F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ78052.1.
    RefSeqiYP_002339170.1. NC_011658.1.

    Genome annotation databases

    EnsemblBacteriaiACJ78052; ACJ78052; BCAH187_A3221.
    GeneIDi7074266.
    KEGGibcr:BCAH187_A3221.
    PATRICi18831873. VBIBacCer120511_3407.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ78052.1 .
    RefSeqi YP_002339170.1. NC_011658.1.

    3D structure databases

    ProteinModelPortali B7HWU2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405534.BCAH187_A3221.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ78052 ; ACJ78052 ; BCAH187_A3221 .
    GeneIDi 7074266.
    KEGGi bcr:BCAH187_A3221.
    PATRICi 18831873. VBIBacCer120511_3407.

    Phylogenomic databases

    eggNOGi COG0394.
    HOGENOMi HOG000273093.
    KOi K03741.
    OMAi GDRYEAY.
    OrthoDBi EOG6JDWJC.

    Enzyme and pathway databases

    BioCyci BCER405534:GHXM-3170-MONOMER.

    Family and domain databases

    HAMAPi MF_01624. Arsenate_reduct.
    InterProi IPR014064. Arsenate_reductase_ArsC.
    IPR023485. Ptyr_pPase_SF.
    IPR017867. Tyr_phospatase_low_mol_wt.
    [Graphical view ]
    PANTHERi PTHR11717. PTHR11717. 1 hit.
    Pfami PF01451. LMWPc. 1 hit.
    [Graphical view ]
    SMARTi SM00226. LMWPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52788. SSF52788. 1 hit.
    TIGRFAMsi TIGR02691. arsC_pI258_fam. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus AH187."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AH187.

    Entry informationi

    Entry nameiARSC_BACC7
    AccessioniPrimary (citable) accession number: B7HWU2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3