B7HVU3 (PCP_BACC7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pyrrolidone-carboxylate peptidase
EC=3.4.19.3

Alternative name(s):
5-oxoprolyl-peptidase
Pyroglutamyl-peptidase I
Short name=PGP-I
Short name=Pyrase

Gene names

Name:	pcp
Ordered Locus Names:	BCAH187_A3115

Organism

Bacillus cereus (strain AH187) [Complete proteome] [HAMAP]

Taxonomic identifier

405534 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus cereus

Protein attributes

Sequence length	215 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Removes 5-oxoproline from various penultimate amino acid residues except L-proline By similarity. HAMAP-Rule MF_00417
Catalytic activity	Release of an N-terminal pyroglutamyl group from a polypeptide, the second amino acid generally not being Pro. HAMAP-Rule MF_00417
Subunit structure	Homotetramer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the peptidase C15 family.

Ontologies

Keywords
Cellular component	Cytoplasm
Molecular function	Hydrolase Protease Thiol protease
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	cysteine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW pyroglutamyl-peptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 215	215	Pyrrolidone-carboxylate peptidase HAMAP-Rule MF_00417		PRO_1000123989
Sites
	Active site	80	1	By similarity
	Active site	143	1	By similarity
	Active site	167	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7HVU3 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 352437CBE86717A6	FASTA	215	23,513
	10 20 30 40 50 60 MKTVLLTGFD PFGGESINPA WEVAKSLHEK TIGEYKIISK QVPTVFHKSI SVLKEYIEEL 70 80 90 100 110 120 APEFIICIGQ AGGRPDITIE RVAINIDDAR IADNEGNQPV DVPVVEEGPA AYWSTLPMKA 130 140 150 160 170 180 IVKKLQEEGI PASVSQTAGT FVCNHLFYGL MHELEKHDTK MKGGFIHIPF LPEQASNYPG 190 200 210 QPSMSLSTIR KGIELAVEVT TTVEVDIVEV GGTTH

References

[1]	"Genome sequence of Bacillus cereus AH187." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AH187.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001177 Genomic DNA. Translation: ACJ80427.1.
RefSeq	YP_002339064.1. NC_011658.1.
3D structure databases
ProteinModelPortal	B7HVU3.
SMR	B7HVU3. Positions 1-207.
ModBase	Search...
Protein-protein interaction databases
STRING	405534.BCAH187_A3115.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACJ80427; ACJ80427; BCAH187_A3115.
GeneID	7073341.
KEGG	bcr:BCAH187_A3115.
PATRIC	18831661. VBIBacCer120511_3301.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2039.
HOGENOM	HOG000242641.
KO	K01304.
OMA	KGGFVHI.
ProtClustDB	PRK13197.
Enzyme and pathway databases
BioCyc	BCER405534:GHXM-3259-MONOMER.
Family and domain databases
Gene3D	3.40.630.20. 1 hit.
HAMAP	MF_00417. Pyrrolid_peptidase.
InterPro	IPR000816. Peptidase_C15. IPR016125. Peptidase_C15-like. [Graphical view]
PANTHER	PTHR23402. PTHR23402. 1 hit.
Pfam	PF01470. Peptidase_C15. 1 hit. [Graphical view]
PIRSF	PIRSF015592. Prld-crbxl_pptds. 1 hit.
PRINTS	PR00706. PYROGLUPTASE.
SUPFAM	SSF53182. Peptidase_C15-like. 1 hit.
TIGRFAMs	TIGR00504. pyro_pdase. 1 hit.
PROSITE	PS01334. PYRASE_CYS. 1 hit. PS01333. PYRASE_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PCP_BACC7

Accession

Primary (citable) accession number: B7HVU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program