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B7HVC7 (B7HVC7_BACC7) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase 1 HAMAP MF_01208
Short name=OPRT 1 HAMAP MF_01208
Short name=OPRTase 1 HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE1 HAMAP MF_01208 EMBL ACJ80673.1
Ordered Locus Names:BCAH187_A0750
OrganismBacillus cereus (strain AH187) [Complete proteome] [HAMAP]
Taxonomic identifier405534 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length180 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region114 – 12295-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site2315-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site8815-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site8915-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9215-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1181Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
B7HVC7 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: D1FD5D8D7EB6E7BB

FASTA18019,936
        10         20         30         40         50         60 
MEKWELAKEI YNTSRLTGTF KLRSGQVSNQ YFDKYLFESN PVLLVEIAKQ LKELIPPETE 

        70         80         90        100        110        120 
VLAGLEMGGI PVATALSLQT GIPVVFVRKE AKKYGTCKLA EGVDIAGKNV CVVEDVITTG 

       130        140        150        160        170        180 
GQILLSTKDL RELGVNVHHV LGVIERTKEG RENLLEDGLQ LHSLFTMDEL IEGEKQHAKS

« Hide

References

[1]"Genome sequence of Bacillus cereus AH187."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001177 Genomic DNA. Translation: ACJ80673.1.
RefSeqYP_002336753.1. NC_011658.1.

3D structure databases

ProteinModelPortalB7HVC7.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7HVC7.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000093574; EBBACP00000088823; EBBACG00000093567.
GeneID7074451.
GenomeReviewsGene locus BCAH187_A0750 in contig CP001177_GR.
KEGGbcr:BCAH187_A0750.
PATRIC18826931. VBIBacCer120511_0963.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000002725.
HOGENOMHBG404341.
OMAQTCLVIN.
ProtClustDBCLSK925627.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB7HVC7_BACC7
AccessionPrimary (citable) accession number: B7HVC7
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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