B7HU66 (GSA1_BACC7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutamate-1-semialdehyde 2,1-aminomutase 1
Short name=GSA 1
EC=5.4.3.8

Alternative name(s):
Glutamate-1-semialdehyde aminotransferase 1
Short name=GSA-AT 1

Gene names

Name:	hemL1
Ordered Locus Names:	BCAH187_A0587

Organism

Bacillus cereus (strain AH187) [Complete proteome] [HAMAP]

Taxonomic identifier

405534 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group › Bacillus cereus

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375
Cofactor	Pyridoxal phosphate By similarity. HAMAP-Rule MF_00375
Pathway	Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2.
Subunit structure	Homodimer By similarity. HAMAP-Rule MF_00375
Subcellular location	Cytoplasm Potential HAMAP-Rule MF_00375.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Ligand	Pyridoxal phosphate
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	chlorophyll biosynthetic process Inferred from electronic annotation. Source: HAMAP protoporphyrinogen IX biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	glutamate-1-semialdehyde 2,1-aminomutase activity Inferred from electronic annotation. Source: HAMAP pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro transaminase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Glutamate-1-semialdehyde 2,1-aminomutase 1 HAMAP-Rule MF_00375		PRO_0000382265
Amino acid modifications
	Modified residue	270	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7HU66 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: B02A06345C49D46D	FASTA	434	46,489
	10 20 30 40 50 60 MVVKFTKSEA LHKEALEHIV GGVNSPSRSF KAVGGGAPVA MERGKGAYFW DVDGNKYIDY 70 80 90 100 110 120 LAAYGPIITG HAHPHITKAI TTAAENGVLY GTPTALEVKF AKMLKEAMPA LDKVRFVNSG 130 140 150 160 170 180 TEAVMTTIRV ARAYTGRTKI MKFAGCYHGH SDLVLVAAGS GPSTLGTPDS AGVPQSIAQE 190 200 210 220 230 240 VITVPFNNVE TLKEALDKWG HEVAAILVEP IVGNFGIVEP KPGFLEKVNE LVHEAGALVI 250 260 270 280 290 300 YDEVITAFRF MYGGAQDLLG VTPDLTALGK VIGGGLPIGA YGGKKEIMEQ VAPLGPAYQA 310 320 330 340 350 360 GTMAGNPASM ASGIACLEVL QQEGLYEKLD ELGAMLEKGI LEQAEKHNID ITLNRLKGAL 370 380 390 400 410 420 TVYFTTNTIE DYDAAQDTDG EMFGKFFKLM LQEGINLAPS KYEAWFLTTE HTKEDIEYTI 430 EAVGRAFAAL ANNK

References

[1]	"Genome sequence of Bacillus cereus AH187." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AH187.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001177 Genomic DNA. Translation: ACJ78777.1.
RefSeq	YP_002336612.1. NC_011658.1.
3D structure databases
ProteinModelPortal	B7HU66.
ModBase	Search...
Protein-protein interaction databases
STRING	405534.BCAH187_A0587.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACJ78777; ACJ78777; BCAH187_A0587.
GeneID	7074643.
KEGG	bcr:BCAH187_A0587.
PATRIC	18826605. VBIBacCer120511_0819.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0001.
HOGENOM	HOG000020210.
KO	K01845.
OMA	KVENYEQ.
ProtClustDB	PRK12389.
Enzyme and pathway databases
BioCyc	BCER405534:GHXM-562-MONOMER.
UniPathway	UPA00251; UER00317.
Family and domain databases
Gene3D	3.40.640.10. 1 hit. 3.90.1150.10. 2 hits.
HAMAP	MF_00375. HemL_aminotrans_3.
InterPro	IPR004639. 4pyrrol_synth_GluAld_NH2Trfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. IPR015422. PyrdxlP-dep_Trfase_major_sub2. [Graphical view]
PANTHER	PTHR11986. PTHR11986. 1 hit. PTHR11986:SF5. PTHR11986:SF5. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
SUPFAM	SSF53383. PyrdxlP-dep_Trfase_major. 1 hit.
TIGRFAMs	TIGR00713. hemL. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSA1_BACC7

Accession

Primary (citable) accession number: B7HU66

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	February 10, 2009
Last modified:	May 29, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program