B7HTM1 (B7HTM1_BACC7) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
ATP-dependent Clp protease proteolytic subunit 1 HAMAP MF_00444
EC=3.4.21.92 HAMAP MF_00444

Alternative name(s):
Endopeptidase Clp 1 HAMAP MF_00444

Gene names

Name:	clpP1 HAMAP MF_00444 EMBL ACJ77601.1
Ordered Locus Names:	BCAH187_A2840

Organism

Bacillus cereus (strain AH187) [Complete proteome] [HAMAP]

Taxonomic identifier

405534 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	193 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins By similarity. HAMAP MF_00444
Catalytic activity	Hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are hydrolyzed (such as succinyl-Leu-Tyr-|-NHMec; and Leu-Tyr-Leu-|-Tyr-Trp, in which cleavage of the -Tyr-|-Leu- and -Tyr-|-Trp bonds also occurs). HAMAP MF_00444
Subcellular location	Cytoplasm By similarity HAMAP MF_00444.
Sequence similarities	Belongs to the peptidase S14 family. RuleBase RU003567 HAMAP MF_00444

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00444
Ligand	ATP-binding HAMAP MF_00444 Nucleotide-binding
Molecular function	Hydrolase Protease Serine protease HAMAP MF_00444
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	proteolysis Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW serine-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	98	1	By similarity HAMAP MF_00444
	Active site	123	1	By similarity HAMAP MF_00444

Sequences

	Sequence		Length	Mass (Da)
	B7HTM1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: E65566BF62D0C8DD	FASTA	193	21,192
	10 20 30 40 50 60 MNAIPYVVEQ TKLGERSYDI YSRLLKDRII IIGSEINDQV ASSVVAQLLF LEAEDAEKDI 70 80 90 100 110 120 FLYINSPGGS TTAGFAILDT MNLIKPDVQT LCMGFAASFG ALLLLSGAKG KRFALPNSEI 130 140 150 160 170 180 MIHQPLGGAK GQATEIEITA KRILKLKHDI NKMIAEKTGQ PIERVAHDTE RDYFMTAEEA 190 KAYGIVDDVV TKK

References

[1]	"Genome sequence of Bacillus cereus AH187." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001177 Genomic DNA. Translation: ACJ77601.1.
RefSeq	YP_002338790.1. NC_011658.1.
3D structure databases
ProteinModelPortal	B7HTM1.
SMR	B7HTM1. Positions 4-193.
ModBase	Search...
Protein-protein interaction databases
STRING	B7HTM1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000095065; EBBACP00000086440; EBBACG00000095058.
GeneID	7074013.
GenomeReviews	Gene locus BCAH187_A2840 in contig CP001177_GR.
KEGG	bcr:BCAH187_A2840.
PATRIC	18831106. VBIBacCer120511_3024.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002046.
HOGENOM	HBG558421.
OMA	KHDINKI.
ProtClustDB	CLSK916804.
Family and domain databases
HAMAP	MF_00444. ClpP. [Tree]
InterPro	IPR023562. Pept_S14/S49. IPR001907. Pept_S14_ClpP. IPR018215. Pept_S14_ClpP_AS. [Graphical view]
KO	K01358.
PANTHER	PTHR10381. Pept_S14_ClpP. 1 hit.
Pfam	PF00574. CLP_protease. 1 hit. [Graphical view]
PRINTS	PR00127. CLPPROTEASEP.
TIGRFAMs	TIGR00493. ClpP. 1 hit.
PROSITE	PS00382. CLP_PROTEASE_HIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B7HTM1_BACC7

Accession

Primary (citable) accession number: B7HTM1

Entry history

Integrated into UniProtKB/TrEMBL:	February 10, 2009
Last sequence update:	February 10, 2009
Last modified:	December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)