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B7HS36

- PUR9_BACC7

UniProt

B7HS36 - PUR9_BACC7

Protein

Bifunctional purine biosynthesis protein PurH

Gene

purH

Organism
Bacillus cereus (strain AH187)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 44 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation
    IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. IMP cyclohydrolase activity Source: UniProtKB-HAMAP
    2. phosphoribosylaminoimidazolecarboxamide formyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase, Transferase

    Keywords - Biological processi

    Purine biosynthesis

    Enzyme and pathway databases

    BioCyciBCER405534:GHXM-351-MONOMER.
    UniPathwayiUPA00074; UER00133.
    UPA00074; UER00135.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional purine biosynthesis protein PurHUniRule annotation
    Including the following 2 domains:
    Phosphoribosylaminoimidazolecarboxamide formyltransferaseUniRule annotation (EC:2.1.2.3UniRule annotation)
    Alternative name(s):
    AICAR transformylaseUniRule annotation
    IMP cyclohydrolaseUniRule annotation (EC:3.5.4.10UniRule annotation)
    Alternative name(s):
    ATICUniRule annotation
    IMP synthaseUniRule annotation
    InosinicaseUniRule annotation
    Gene namesi
    Name:purHUniRule annotation
    Ordered Locus Names:BCAH187_A0371
    OrganismiBacillus cereus (strain AH187)
    Taxonomic identifieri405534 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002214: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 511511Bifunctional purine biosynthesis protein PurHPRO_1000117867Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi405534.BCAH187_A0371.

    Structurei

    3D structure databases

    ProteinModelPortaliB7HS36.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domaini

    The IMP cyclohydrolase activity resides in the N-terminal region.UniRule annotation

    Sequence similaritiesi

    Belongs to the PurH family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0138.
    HOGENOMiHOG000230373.
    KOiK00602.
    OMAiRAFKTDP.
    OrthoDBiEOG6QCDFF.

    Family and domain databases

    Gene3Di3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPiMF_00139. PurH.
    InterProiIPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view]
    PANTHERiPTHR11692. PTHR11692. 1 hit.
    PfamiPF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTiSM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsiTIGR00355. purH. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7HS36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQRALVSVS DKTGVVEFVK GLLEQGIEVI STGGTKKLLE ENGLQVIGIS    50
    EVTGFPEIMD GRVKTLHPNI HGGLLAVRDN ETHVAQMNEL GIEPIDFVVV 100
    NLYPFKETIA KPDVTFADAI ENIDIGGPTM IRSAAKNHKF VSVIVDPVDY 150
    DVVLAELEEN GEVKEETKRK LAAKVFRHTA AYDALISNYL TEQMGEESPE 200
    TLTVTFEKKQ DLRYGENPHQ KATFYKAPFA ATSSVAYAEQ LHGKELSYNN 250
    INDADAALSI VKEFTEPAVV AVKHMNPCGV GVGTDIHEAY TRAYEADPVS 300
    IFGGIIAANR EIDKSTAEKL HEIFLEIIIA PSFSKEALEV LQSKKNLRLL 350
    TVNIEKSTSA SKKLTSVQGG LLVQEEDTLS LDESTISIPT KREPSEQEWK 400
    DLKLAWKVVK HVKSNAIVLA KDDMTIGVGA GQMNRVGSAK IAITQAGEKA 450
    QGSALASDAF FPMPDTLEEA AKAGITAIIQ PGGSIRDEDS IKVADTYGIA 500
    MVFTGVRHFK H 511
    Length:511
    Mass (Da):55,602
    Last modified:February 10, 2009 - v1
    Checksum:iCE1D240EB40D4D0A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ80890.1.
    RefSeqiYP_002336401.1. NC_011658.1.

    Genome annotation databases

    EnsemblBacteriaiACJ80890; ACJ80890; BCAH187_A0371.
    GeneIDi7078347.
    KEGGibcr:BCAH187_A0371.
    PATRICi18826183. VBIBacCer120511_0608.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ80890.1 .
    RefSeqi YP_002336401.1. NC_011658.1.

    3D structure databases

    ProteinModelPortali B7HS36.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405534.BCAH187_A0371.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ80890 ; ACJ80890 ; BCAH187_A0371 .
    GeneIDi 7078347.
    KEGGi bcr:BCAH187_A0371.
    PATRICi 18826183. VBIBacCer120511_0608.

    Phylogenomic databases

    eggNOGi COG0138.
    HOGENOMi HOG000230373.
    KOi K00602.
    OMAi RAFKTDP.
    OrthoDBi EOG6QCDFF.

    Enzyme and pathway databases

    UniPathwayi UPA00074 ; UER00133 .
    UPA00074 ; UER00135 .
    BioCyci BCER405534:GHXM-351-MONOMER.

    Family and domain databases

    Gene3Di 3.40.140.20. 2 hits.
    3.40.50.1380. 1 hit.
    HAMAPi MF_00139. PurH.
    InterProi IPR024051. AICAR_Tfase_dom.
    IPR002695. AICARFT_IMPCHas.
    IPR016193. Cytidine_deaminase-like.
    IPR011607. MGS-like_dom.
    [Graphical view ]
    PANTHERi PTHR11692. PTHR11692. 1 hit.
    Pfami PF01808. AICARFT_IMPCHas. 1 hit.
    PF02142. MGS. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000414. AICARFT_IMPCHas. 1 hit.
    SMARTi SM00798. AICARFT_IMPCHas. 1 hit.
    SM00851. MGS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52335. SSF52335. 1 hit.
    SSF53927. SSF53927. 1 hit.
    TIGRFAMsi TIGR00355. purH. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus AH187."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AH187.

    Entry informationi

    Entry nameiPUR9_BACC7
    AccessioniPrimary (citable) accession number: B7HS36
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 44 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3