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B7HNY9

- GCSPB_BACC7

UniProt

B7HNY9 - GCSPB_BACC7

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 2

Gene

gcvPB

Organism
Bacillus cereus (strain AH187)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 40 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciBCER405534:GHXM-4291-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 2UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 2UniRule annotation
    Glycine decarboxylase subunit 2UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 2UniRule annotation
    Gene namesi
    Name:gcvPBUniRule annotation
    Ordered Locus Names:BCAH187_A4356
    OrganismiBacillus cereus (strain AH187)
    Taxonomic identifieri405534 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000002214: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Probable glycine dehydrogenase (decarboxylating) subunit 2PRO_1000132494Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei273 – 2731N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi405534.BCAH187_A4356.

    Structurei

    3D structure databases

    ProteinModelPortaliB7HNY9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. C-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239368.
    KOiK00283.
    OMAiWTGLMMI.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00713. GcvPB.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7HNY9-1 [UniParc]FASTAAdd to Basket

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    MKNQDQALIF EVSKEGRIGY SLPKLDVEEV KLEDVFESDY IRVEDAELPE    50
    VSELDIMRHY TALSNRNHGV DSGFYPLGSC TMKYNPKINE SVARFAGFAN 100
    IHPLQDEKTV QGAMELMYDL QEHLIEITGM DTVTLQPAAG AHGEWTGLML 150
    IRAYHEANGD FNRTKVIVPD SAHGTNPASA TVAGFETITV KSNEHGLVDL 200
    EDLKRVVNEE TAALMLTNPN TLGLFEENIL EMAEIVHNAG GKLYYDGANL 250
    NAVLSQARPG DMGFDVVHLN LHKTFTGPHG GGGPGSGPVG VKADLIPYLP 300
    KPILEKTENG YHFNYDRPEA IGRVKPFYGN FGINVRAYTY IRSMGPDGLR 350
    AVTEYAVLNA NYMMRRLAPF YDLPFDRHCK HEFVLSGRRQ KKLGVRTLDI 400
    AKRLLDFGYH PPTIYFPLNV EECIMIEPTE TESKETLDGF IDKMIQIAKE 450
    VEENPEVVQE APHTTVIKRL DETMAARKPV LRYEKPAPVQ V 491
    Length:491
    Mass (Da):54,923
    Last modified:February 10, 2009 - v1
    Checksum:iB7BDB06348664B0D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ80737.1.
    RefSeqiYP_002340286.1. NC_011658.1.

    Genome annotation databases

    EnsemblBacteriaiACJ80737; ACJ80737; BCAH187_A4356.
    GeneIDi7075037.
    KEGGibcr:BCAH187_A4356.
    PATRICi18834143. VBIBacCer120511_4542.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001177 Genomic DNA. Translation: ACJ80737.1 .
    RefSeqi YP_002340286.1. NC_011658.1.

    3D structure databases

    ProteinModelPortali B7HNY9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405534.BCAH187_A4356.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ80737 ; ACJ80737 ; BCAH187_A4356 .
    GeneIDi 7075037.
    KEGGi bcr:BCAH187_A4356.
    PATRICi 18834143. VBIBacCer120511_4542.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239368.
    KOi K00283.
    OMAi WTGLMMI.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci BCER405534:GHXM-4291-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00713. GcvPB.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR023012. GDC_P_su2.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus AH187."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AH187.

    Entry informationi

    Entry nameiGCSPB_BACC7
    AccessioniPrimary (citable) accession number: B7HNY9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 40 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3