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Protein

Ribonuclease Z

Gene

rnz

Organism
Bacillus cereus (strain AH187)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage of RNA, removing extra 3' nucleotides from tRNA precursor, generating 3' termini of tRNAs. A 3'-hydroxy group is left at the tRNA terminus and a 5'-phosphoryl group is left at the trailer molecule.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 2 Zn2+ ions.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi63Zinc 1; catalyticUniRule annotation1
Metal bindingi65Zinc 1; catalyticUniRule annotation1
Active sitei67Proton acceptorUniRule annotation1
Metal bindingi67Zinc 2; catalyticUniRule annotation1
Metal bindingi68Zinc 2; catalyticUniRule annotation1
Metal bindingi141Zinc 1; catalyticUniRule annotation1
Metal bindingi212Zinc 1; catalyticUniRule annotation1
Metal bindingi212Zinc 2; catalyticUniRule annotation1
Metal bindingi270Zinc 2; catalyticUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionEndonuclease, Hydrolase, Nuclease
Biological processtRNA processing
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease ZUniRule annotation (EC:3.1.26.11UniRule annotation)
Short name:
RNase ZUniRule annotation
Alternative name(s):
tRNA 3 endonucleaseUniRule annotation
tRNase ZUniRule annotation
Gene namesi
Name:rnzUniRule annotation
Ordered Locus Names:BCAH187_A4274
OrganismiBacillus cereus (strain AH187)
Taxonomic identifieri405534 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000002214 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001879341 – 307Ribonuclease ZAdd BLAST307

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7HNQ7.
SMRiB7HNQ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RNase Z family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000272419.
KOiK00784.
OMAiGTQRQMM.

Family and domain databases

CDDicd07717. RNaseZ_ZiPD-like_MBL-fold. 1 hit.
Gene3Di3.60.15.10. 1 hit.
HAMAPiMF_01818. RNase_Z_BN. 1 hit.
InterProiView protein in InterPro
IPR001279. Metallo-B-lactamas.
IPR036866. Metallo-hydrolase/OxRdtase.
IPR013471. RNase_Z/BN.
PfamiView protein in Pfam
PF00753. Lactamase_B. 1 hit.
PF12706. Lactamase_B_2. 1 hit.
SMARTiView protein in SMART
SM00849. Lactamase_B. 1 hit.
SUPFAMiSSF56281. SSF56281. 1 hit.
TIGRFAMsiTIGR02651. RNase_Z. 1 hit.

Sequencei

Sequence statusi: Complete.

B7HNQ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFVFLGTGA GVPSKGRNVS AIALQLLEER GQTWLFDCGE ATQHQILHTS
60 70 80 90 100
VRPRRIEKIF ITHLHGDHIF GLPGLLGSRS FQGGTTPLTV YGPKGIKQFI
110 120 130 140 150
EVALSVSTTH VKYPLEIVEI TEEGTVFEDN EFHVETKRLS HGIECFGYRI
160 170 180 190 200
IEKDIQGALL VDKLLEMGVK PGPLFKRLKD GEVVELENGT ILNGQDFIGP
210 220 230 240 250
PQKGRIITIL GDTRFCEASR ELAQDADVLV HEATFAAEDE QQAYDYFHST
260 270 280 290 300
SKQAASIALQ ANAKRLILTH ISSRYQGDTY KELLKEAREL FSNTEIATDL

KSFPVER
Length:307
Mass (Da):34,225
Last modified:February 10, 2009 - v1
Checksum:i321573FE331A8644
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001177 Genomic DNA. Translation: ACJ79366.1.
RefSeqiWP_000397447.1. NC_011658.1.

Genome annotation databases

EnsemblBacteriaiACJ79366; ACJ79366; BCAH187_A4274.
KEGGibcr:BCAH187_A4274.

Similar proteinsi

Entry informationi

Entry nameiRNZ_BACC7
AccessioniPrimary (citable) accession number: B7HNQ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 25, 2017
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families