Skip Header

Contribute Send feedback
Read comments (?) or add your own

B7HMM6 (B7HMM6_BACC7) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 22. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Ketol-acid reductoisomerase 2 HAMAP MF_00435
EC=1.1.1.86 HAMAP MF_00435
Alternative name(s):
Acetohydroxy-acid isomeroreductase 2 HAMAP MF_00435
Alpha-keto-beta-hydroxylacil reductoisomerase 2 HAMAP MF_00435
Gene names
Name:ilvC2 HAMAP MF_00435 EMBL ACJ78118.1
Ordered Locus Names:BCAH187_A1968
OrganismBacillus cereus (strain AH187) [Complete proteome] [HAMAP]
Taxonomic identifier405534 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(2R,3R)-2,3-dihydroxy-3-methylpentanoate + NADP+ = (S)-2-hydroxy-2-ethyl-3-oxobutanoate + NADPH. HAMAP MF_00435

(R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH. HAMAP MF_00435

Pathway

Amino-acid biosynthesis; L-isoleucine biosynthesis; L-isoleucine from 2-oxobutanoate: step 2/4. HAMAP MF_00435

Amino-acid biosynthesis; L-valine biosynthesis; L-valine from pyruvate: step 2/4. HAMAP MF_00435

Sequence similarities

Belongs to the ketol-acid reductoisomerase family. HAMAP MF_00435

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site1061 By similarity HAMAP MF_00435

Sequences

Sequence LengthMass (Da)Tools
B7HMM6 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 5FFA607C9968B2DD

FASTA33536,932
        10         20         30         40         50         60 
MKTYYEQDAN VELLKGKTVA VIGYGSQGHA QAQNLRDSGV EVVVGVRPGK SFEVAKADGF 

        70         80         90        100        110        120 
EVMSVSEAVR TAQVVQMLLP DEQQAHVYKA EVEENLREGQ MLLFSHGFNI HFGQINPPSY 

       130        140        150        160        170        180 
VDVAMVAPKS PGHLVRRVFQ EGNGVPALVA VHQDATGTAL HVALAYAKGV GCTRAGVIET 

       190        200        210        220        230        240 
TFQEETETDL FGEQAVLCGG VTALVKAGFE TLTEGGYRPE IAYFECLHEL KLIVDLMYEG 

       250        260        270        280        290        300 
GLTNMRHSIS DTAEFGDYVT GSRIVTDETK KEMKRVLTEI QQGEFAKKWI LENQAGRPTY 

       310        320        330 
NAMKKAEQNH QLEKVGAELR EMMSWIHAPK ELVKK

« Hide

References

[1]"Genome sequence of Bacillus cereus AH187."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001177 Genomic DNA. Translation: ACJ78118.1.
RefSeqYP_002337922.1. NC_011658.1.

3D structure databases

ProteinModelPortalB7HMM6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7HMM6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000091983; EBBACP00000088490; EBBACG00000091976.
GeneID7078078.
GenomeReviewsGene locus BCAH187_A1968 in contig CP001177_GR.
KEGGbcr:BCAH187_A1968.
PATRIC18829331. VBIBacCer120511_2139.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000000943.
HOGENOMHBG286525.
OMARPGKSYE.
ProtClustDBPRK13403.

Family and domain databases

HAMAPMF_00435. IlvC.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013023. AcH_isomrdctse.
IPR000506. AcH_isomrdctse_C.
IPR013328. DH_multihelical.
IPR013116. IlvN.
[Graphical view]
Gene3DG3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00053.
PANTHERPTHR21371. AcH_isomrdctse. 1 hit.
PfamPF01450. IlvC. 1 hit.
PF07991. IlvN. 1 hit.
[Graphical view]
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
TIGRFAMsTIGR00465. IlvC. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB7HMM6_BACC7
AccessionPrimary (citable) accession number: B7HMM6
Entry history
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: December 14, 2011
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info