Reviewed,
UniProtKB/Swiss-Prot B7HLM7 (LSPA_BACC7)
Last modified
February 9, 2010.
Version 13.
History...
Clusters with 100%,
90%,
50% identity |
Documents (3) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Lipoprotein signal peptidase EC=3.4.23.36 Alternative name(s): Prolipoprotein signal peptidase Signal peptidase II Short name=SPase II | ||||
| Gene names |
| ||||
| Organism | Bacillus cereus (strain AH187) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 405534 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group |
Protein attributes
| Sequence length | 152 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | This protein specifically catalyzes the removal of signal peptides from prolipoproteins By similarity. HAMAP MF_00161 |
| Catalytic activity | Release of signal peptides from bacterial membrane prolipoproteins. Hydrolyzes -Xaa-Yaa-Zaa-|-(S,diacylglyceryl)Cys-, in which Xaa is hydrophobic (preferably Leu), and Yaa (Ala or Ser) and Zaa (Gly or Ala) have small, neutral side chains. HAMAP MF_00161 |
| Pathway | Protein modification; lipoprotein biosynthesis (signal peptide cleavage). HAMAP MF_00161 |
| Subcellular location | Cell membrane; Multi-pass membrane protein By similarity HAMAP MF_00161. |
| Sequence similarities | Belongs to the peptidase A8 family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane |
| Domain | Transmembrane |
| Molecular function | Aspartyl protease Hydrolase Protease |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | proteolysis Inferred from electronic annotation. Source: InterPro |
| Cellular component | integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membraneInferred from electronic annotation. Source: HAMAP |
| Molecular function | aspartic-type endopeptidase activity Inferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 152 | 152 | Lipoprotein signal peptidase HAMAP MF_00161 | PRO_1000190788 | |||||
Regions | |||||||||
| Transmembrane | 55 – 75 | 21 | Potential | ||||||
| Transmembrane | 85 – 105 | 21 | Potential | ||||||
| Transmembrane | 124 – 144 | 21 | Potential | ||||||
Sites | |||||||||
| Active site | 102 | 1 | By similarity | ||||||
| Active site | 129 | 1 | By similarity | ||||||
Sequences
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References
| [1] | "Genome sequence of Bacillus cereus AH187." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP001177 Genomic DNA. Translation: ACJ78047.1. |
| RefSeq | YP_002339882.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 7074098. |
| GenomeReviews | Gene locus BCAH187_A3945 in contig CP001177_GR. |
| KEGG | bcr:BCAH187_A3945. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG724422. |
| OMA | DGAGWQR. |
Family and domain databases | |
| HAMAP | MF_00161. LspA. [Tree] |
| InterPro | IPR001872. Peptidase_A8. [Graphical view] |
| Pfam | PF01252. Peptidase_A8. 1 hit. [Graphical view] |
| PRINTS | PR00781. LIPOSIGPTASE. |
| TIGRFAMs | TIGR00077. lspA. 1 hit. |
| PROSITE | PS00855. SPASE_II. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | LSPA_BACC7 | ||||||||
| Accession | Primary (citable) accession number: B7HLM7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| Peptidase families Classification of peptidase families and list of entries |
| SIMILARITY comments Index of protein domains and families |

Clusters with


