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B7HL27 (AROB_BACC7) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 25. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BCAH187_A1680
OrganismBacillus cereus (strain AH187) [Complete proteome] [HAMAP]
Taxonomic identifier405534 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length365 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3653653-dehydroquinate synthase HAMAP MF_00110
PRO_1000117474

Sequences

Sequence LengthMass (Da)Tools
B7HL27 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 563313392852CE60

FASTA36540,546
        10         20         30         40         50         60 
MENIHIQTKS KEYDVHVGKE SLSHLTTIVQ NMQPSVSNIM IISDEAVAPL HLQTVVDALQ 

        70         80         90        100        110        120 
IDQKVFSFVV PSGEKEKSFE NFYAAHTSAL ENKLDRNSLI IALGGGMIGD LAGFVAASFM 

       130        140        150        160        170        180 
RGIRFVQVPT TLLAHDSAVG GKVAINHPLG KNMIGAFHQP EAVVYHTPFL QSLPEKEWRS 

       190        200        210        220        230        240 
GYAEVIKHAL IGDVKLYHWL KEEVQTLADL RDEKLIHILT KAIPVKANIV AQDETEKGVR 

       250        260        270        280        290        300 
AHLNFGHTLG HALEKELGYG NITHGDGVAV GMLFAIFLSE QVYKVNLAYE EMKQWFLKYG 

       310        320        330        340        350        360 
YPKMPSDLSV ERLVGLMKQD KKANAGTIHM VLMQEYGVVN VVSIPDETVH IALEAFQKDM 


GIRSR

« Hide

References

[1]"Genome sequence of Bacillus cereus AH187."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AH187.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001177 Genomic DNA. Translation: ACJ81095.1.
RefSeqYP_002337642.1. NC_011658.1.

3D structure databases

ProteinModelPortalB7HL27.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7HL27.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000092269; EBBACP00000087262; EBBACG00000092262.
GeneID7077323.
GenomeReviewsGene locus BCAH187_A1680 in contig CP001177_GR.
KEGGbcr:BCAH187_A1680.
PATRIC18828771. VBIBacCer120511_1859.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000002325.
HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BACC7
AccessionPrimary (citable) accession number: B7HL27
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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