B7HL21 (GCH1_BACC7) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	BCAH187_A1674

Organism

Bacillus cereus (strain AH187) [Complete proteome] [HAMAP]

Taxonomic identifier

405534 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP MF_00223
Subunit structure	Homopolymer By similarity. HAMAP MF_00223
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	Metal-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	GTP cyclohydrolase I activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	GTP cyclohydrolase 1 HAMAP MF_00223		PRO_1000190068
Sites
	Metal binding	78	1	Zinc By similarity
	Metal binding	81	1	Zinc By similarity
	Metal binding	150	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7HL21 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 0A8B0379657B322B	FASTA	189	21,020
	10 20 30 40 50 60 MAKVNLEQIE HAVRLILEAI GDDPNREGVL DTPKRVAKMY AEVFSGMHED PKEHLHKVFG 70 80 90 100 110 120 EDHEELVLVK DIPFYSMCEH HLVPFYGVAH VAYIPQGGKV TGLSKLARTV DTIARRPQLQ 130 140 150 160 170 180 ERITSTVANS IMEVLEPHGV MVVVEAEHMC MTMRGVKKPG AKTVTTAVRG VLENDAAARS EILSFIKTK

References

[1]	"Genome sequence of Bacillus cereus AH187." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Kolsto A.B., Okstad O.A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AH187.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001177 Genomic DNA. Translation: ACJ81058.1.
RefSeq	YP_002337636.1. NC_011658.1.
3D structure databases
ProteinModelPortal	B7HL21.
ModBase	Search...
Protein-protein interaction databases
STRING	B7HL21.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000095182; EBBACP00000087680; EBBACG00000095175.
GeneID	7075740.
GenomeReviews	Gene locus BCAH187_A1674 in contig CP001177_GR.
KEGG	bcr:BCAH187_A1674.
PATRIC	18828759. VBIBacCer120511_1853.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000002882.
HOGENOM	HBG370191.
OMA	LPFMGRA.
ProtClustDB	PRK09347.
Family and domain databases
HAMAP	MF_00223. FolE. [Tree]
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
KO	K01495.
PANTHER	PTHR11109. GTP_cyclohydro_I. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. FolE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_BACC7

Accession

Primary (citable) accession number: B7HL21

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program