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Protein

DNA topoisomerase

Gene

topB2

Organism
Bacillus cereus (strain B4264)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP-independent breakage of single-stranded DNA, followed by passage and rejoining.SAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation, Isomerase, TopoisomeraseSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
DNA topoisomeraseSAAS annotation (EC:5.99.1.2SAAS annotation)
Gene namesi
Name:topB2Imported
Ordered Locus Names:BCB4264_A1911Imported
OrganismiBacillus cereus (strain B4264)Imported
Taxonomic identifieri405532 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000007096 Componenti: Chromosome

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 140ToprimInterPro annotationAdd BLAST140

Sequence similaritiesi

Belongs to the type IA topoisomerase family.SAAS annotation

Phylogenomic databases

HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
cd03362. TOPRIM_TopoIA_TopoIII. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiView protein in InterPro
IPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR025589. Toprim_C_rpt.
IPR006171. TOPRIM_domain.
IPR034144. TOPRIM_TopoIII.
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiView protein in Pfam
PF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF13342. Toprim_Crpt. 1 hit.
PRINTSiPR00417. PRTPISMRASEI.
SMARTiView protein in SMART
SM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiView protein in PROSITE
PS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.

Sequencei

Sequence statusi: Complete.

B7HIU6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLIIAEKPD QGLALVSQFK YRRKDGYLEV EANELFPNGA YCTWAIGHLT
60 70 80 90 100
QLCNPEHYHA EWKKWSLDTL PMIPERFQFE VTKSKYKQFN VVKQLLHNPQ
110 120 130 140 150
VTEIIHAGDA GREGELIVRN IINLCNVQKP MKRLWISSLT KQAIYQGFKN
160 170 180 190 200
LLDESDTINT YYEAYTRSCA DWVVGMNASR VFSILLKKKG MNDVFSAGRV
210 220 230 240 250
QTPTLALIVK REKEIENFKS EPFWEVFATF NIEGKKYDGK WEKDNESRLK
260 270 280 290 300
DPDMANKIAA FCQGKPAVVK EMKTERKEFQ PPLLFNLSSL QATANKAFKF
310 320 330 340 350
SPKKTLDITQ ALYQKGIVSY PRSDSNYVTQ GEAATFPDIL QKLSQFDEYK
360 370 380 390 400
GLLPAPVESI MNNKRYVNEK KVTDHYAIIP TEQVTNPSRL SGDEKKIYDM
410 420 430 440 450
IVRRLIAAHY EVAIFDYTTI VTLVDERAEF ISKGKQQIQE GWRKVIFQDD
460 470 480 490 500
KDDETILPIV AEGEEGKVVK VKVKEGKTQP PKRYTEGQLI TLMKTAGKYL
510 520 530 540 550
ENEELEKVLK KTEGLGTEAT RAGIITMLKD RKYIDVKKNQ VYATDKGKVL
560 570 580 590 600
ITAIGDKILA SPEMTAKWEQ RLAEIGEGTA SPATFMEQTK KLSAKIIEDA
610 620 630 640 650
VEMSEKWDFT GLHVESIERK GSKFTTGKKV GSCKKCDGDV IDKSTFYGCS
660 670 680 690 700
NYNTTQCDFT ISKKILSKTI SQKNMTKLLR GEKTDLIKGF KKGEKTFDAK
710
LEWKDNKINF VFEN
Length:714
Mass (Da):81,531
Last modified:February 10, 2009 - v1
Checksum:iDA3E589EE4EB4AAF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001176 Genomic DNA. Translation: ACK58823.1.
RefSeqiWP_000766735.1. NC_011725.1.

Genome annotation databases

EnsemblBacteriaiACK58823; ACK58823; BCB4264_A1911.
KEGGibcb:BCB4264_A1911.
PATRICi18875753. VBIBacCer117876_1785.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001176 Genomic DNA. Translation: ACK58823.1.
RefSeqiWP_000766735.1. NC_011725.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK58823; ACK58823; BCB4264_A1911.
KEGGibcb:BCB4264_A1911.
PATRICi18875753. VBIBacCer117876_1785.

Phylogenomic databases

HOGENOMiHOG000086847.
KOiK03169.
OMAiMSRACAD.

Family and domain databases

CDDicd00186. TOP1Ac. 1 hit.
cd03362. TOPRIM_TopoIA_TopoIII. 1 hit.
Gene3Di1.10.460.10. 2 hits.
2.70.20.10. 2 hits.
3.40.50.140. 1 hit.
InterProiView protein in InterPro
IPR000380. Topo_IA.
IPR003601. Topo_IA_2.
IPR023406. Topo_IA_AS.
IPR013497. Topo_IA_cen.
IPR013824. Topo_IA_cen_sub1.
IPR013825. Topo_IA_cen_sub2.
IPR023405. Topo_IA_core_domain.
IPR003602. Topo_IA_DNA-bd_dom.
IPR005738. TopoIII.
IPR025589. Toprim_C_rpt.
IPR006171. TOPRIM_domain.
IPR034144. TOPRIM_TopoIII.
PANTHERiPTHR11390. PTHR11390. 1 hit.
PfamiView protein in Pfam
PF01131. Topoisom_bac. 1 hit.
PF01751. Toprim. 1 hit.
PF13342. Toprim_Crpt. 1 hit.
PRINTSiPR00417. PRTPISMRASEI.
SMARTiView protein in SMART
SM00437. TOP1Ac. 1 hit.
SM00436. TOP1Bc. 1 hit.
SM00493. TOPRIM. 1 hit.
SUPFAMiSSF56712. SSF56712. 1 hit.
TIGRFAMsiTIGR01056. topB. 1 hit.
PROSITEiView protein in PROSITE
PS00396. TOPOISOMERASE_I_PROK. 1 hit.
PS50880. TOPRIM. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB7HIU6_BACC4
AccessioniPrimary (citable) accession number: B7HIU6
Entry historyiIntegrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: February 15, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.