Reviewed, UniProtKB/Swiss-Prot B7HHS1 (AROB_BACC4)

Names and origin

Protein names

Recommended name:
    3-dehydroquinate synthase
    EC=4.2.3.4

Gene names

Name:	aroB
Ordered Locus Names:	BCB4264_A1573

Organism

Bacillus cereus (strain B4264) [Complete proteome] [HAMAP]

Taxonomic identifier

405532 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	361 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110
Cofactor	Divalent metal cations By similarity. HAMAP MF_00110 NAD By similarity. HAMAP MF_00110
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110
Subunit structure	Monomer By similarity. HAMAP MF_00110
Subcellular location	Cytoplasm By similarity HAMAP MF_00110.
Sequence similarities	Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Cellular component	Cytoplasm
Ligand	NAD
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3-dehydroquinate synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 361	361	3-dehydroquinate synthase HAMAP MF_00110		PRO_1000117473

Sequences

	Sequence		Length	Mass (Da)
	B7HHS1-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 178B17ED2AA53ECB	FASTA	361	40,073
	10 20 30 40 50 60 MGNIHIQTKS KEYDVHVGKE VLSNLTTIVQ NMQPAVSNVM IISDEAVASL HLQTVIDALQ 70 80 90 100 110 120 VEQHVFSFVV PSGEKEKSFE NFYAAHTSAL ENKLDRNSLI LALGGGMIGD LAGFVAASFM 130 140 150 160 170 180 RGIRFVQVPT TLLAHDSAVG GKVAINHPLG KNMIGAFHQP EAVVYHTPFL QSLPEKEWRS 190 200 210 220 230 240 GYAEVIKHAL IGDVELYHWL KEEVQTLADL HDEKLIHILT KAIPVKANVV SQDETEKGVR 250 260 270 280 290 300 AHLNFGHTLG HALEKELGYG NITHGDGVAV GMLFAIFLSE QVYKVDLAYE DMKQWFLKYG 310 320 330 340 350 360 YPKMPRDLNV ERLVQLMKQD KKANAGAIHM VLMQEYGVVN VVSISDETVH IALEAFQKDM V

References

[1]	"Genome sequence of Bacillus cereus B4264." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001176 Genomic DNA. Translation: ACK61649.1.
RefSeq	YP_002366298.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7099863.
GenomeReviews	Gene locus BCB4264_A1573 in contig CP001176_GR.
KEGG	bcb:BCB4264_A1573.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG632303.
Family and domain databases
HAMAP	MF_00110. DHQ_synthase. [Tree]
InterPro	IPR016303. DHQ_synth. IPR002658. DHQ_synth_AroB. IPR016037. DHQ_synth_AroB_sub. [Graphical view]
PANTHER	PTHR21090:SF1. DHQ_synth_AroB. 1 hit.
Pfam	PF01761. DHQ_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001455. DHQ_synth. 1 hit.
TIGRFAMs	TIGR01357. aroB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

AROB_BACC4

Accession

Primary (citable) accession number: B7HHS1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	February 9, 2010
This is version 10 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)