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B7HHS1 (AROB_BACC4) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BCB4264_A1573
OrganismBacillus cereus (strain B4264) [Complete proteome] [HAMAP]
Taxonomic identifier405532 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length361 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3613613-dehydroquinate synthase HAMAP MF_00110
PRO_1000117473

Sequences

Sequence LengthMass (Da)Tools
B7HHS1 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 178B17ED2AA53ECB

FASTA36140,073
        10         20         30         40         50         60 
MGNIHIQTKS KEYDVHVGKE VLSNLTTIVQ NMQPAVSNVM IISDEAVASL HLQTVIDALQ 

        70         80         90        100        110        120 
VEQHVFSFVV PSGEKEKSFE NFYAAHTSAL ENKLDRNSLI LALGGGMIGD LAGFVAASFM 

       130        140        150        160        170        180 
RGIRFVQVPT TLLAHDSAVG GKVAINHPLG KNMIGAFHQP EAVVYHTPFL QSLPEKEWRS 

       190        200        210        220        230        240 
GYAEVIKHAL IGDVELYHWL KEEVQTLADL HDEKLIHILT KAIPVKANVV SQDETEKGVR 

       250        260        270        280        290        300 
AHLNFGHTLG HALEKELGYG NITHGDGVAV GMLFAIFLSE QVYKVDLAYE DMKQWFLKYG 

       310        320        330        340        350        360 
YPKMPRDLNV ERLVQLMKQD KKANAGAIHM VLMQEYGVVN VVSISDETVH IALEAFQKDM 


V

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References

[1]"Genome sequence of Bacillus cereus B4264."
Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: B4264.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001176 Genomic DNA. Translation: ACK61649.1.
RefSeqYP_002366298.1. NC_011725.1.

3D structure databases

ProteinModelPortalB7HHS1.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7HHS1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaEBBACT00000111055; EBBACP00000108135; EBBACG00000111048.
GeneID7099863.
GenomeReviewsGene locus BCB4264_A1573 in contig CP001176_GR.
KEGGbcb:BCB4264_A1573.
PATRIC18875091. VBIBacCer117876_1454.

Organism-specific databases

CMRSearch...

Phylogenomic databases

GeneTreeEBGT00050000002325.
HOGENOMHBG632303.
OMAGTFTQPD.
ProtClustDBPRK00002.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BACC4
AccessionPrimary (citable) accession number: B7HHS1
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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