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Protein

N-(5'-phosphoribosyl)anthranilate isomerase

Gene

trpF

Organism
Bacillus cereus (strain B4264)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi: L-tryptophan biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes L-tryptophan from chorismate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Anthranilate synthase component 1 (pabB), Anthranilate synthase component 1 (trpE)
  2. Anthranilate phosphoribosyltransferase (trpD)
  3. N-(5'-phosphoribosyl)anthranilate isomerase (trpF)
  4. Indole-3-glycerol phosphate synthase (trpC)
  5. Tryptophan synthase beta chain (trpB), Tryptophan synthase alpha chain (trpA)
This subpathway is part of the pathway L-tryptophan biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-tryptophan from chorismate, the pathway L-tryptophan biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomeraseUniRule annotation (EC:5.3.1.24UniRule annotation)
Short name:
PRAIUniRule annotation
Gene namesi
Name:trpFUniRule annotation
Ordered Locus Names:BCB4264_A1295
OrganismiBacillus cereus (strain B4264)
Taxonomic identifieri405532 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
Proteomesi
  • UP000007096 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001970781 – 204N-(5'-phosphoribosyl)anthranilate isomeraseAdd BLAST204

Structurei

3D structure databases

ProteinModelPortaliB7HH00.
SMRiB7HH00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000161598.
KOiK01817.
OMAiFYAKSPR.

Family and domain databases

CDDicd00405. PRAI. 1 hit.
Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI. 1 hit.
InterProiView protein in InterPro
IPR013785. Aldolase_TIM.
IPR001240. PRAI.
IPR011060. RibuloseP-bd_barrel.
PfamiView protein in Pfam
PF00697. PRAI. 1 hit.
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

B7HH00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVKICGITD VETAKSACEY GADALGFVFA ESKRKITPKR AKEIIQELPA
60 70 80 90 100
NVLKIGVFVN ESVEVIQKIA DECGLTHVQL HGDEDNYQIR RLNILCIKSL
110 120 130 140 150
GVTSERDMKN AQRYETDYIL FDSPKEKFHG GNGKTFSWEL LGHMPKELRK
160 170 180 190 200
KTILAGGLNA LNIEEAIRTV RPYMVDVSSG VETEGKKDVE KIKQFIIKAK

ECSK
Length:204
Mass (Da):22,905
Last modified:February 10, 2009 - v1
Checksum:iD48D973F51F05C6C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001176 Genomic DNA. Translation: ACK59544.1.
RefSeqiWP_000865145.1. NC_011725.1.

Genome annotation databases

EnsemblBacteriaiACK59544; ACK59544; BCB4264_A1295.
KEGGibcb:BCB4264_A1295.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiTRPF_BACC4
AccessioniPrimary (citable) accession number: B7HH00
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: June 7, 2017
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families