B7HGZ9 (TRPC_BACC4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	BCB4264_A1294

Organism

Bacillus cereus (strain B4264) [Complete proteome] [HAMAP]

Taxonomic identifier

405532 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	253 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 253	253	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000117770

Sequences

	Sequence		Length	Mass (Da)
	B7HGZ9 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 1147741A12CF2F37	FASTA	253	28,356
	10 20 30 40 50 60 MGTILDEIVE QKQREVAELY EIYTPVKTKR KTHSLVEALQ QFTVIAEVKR ASPSKGDINL 70 80 90 100 110 120 HVDVRKQVGT YEKCGAGAVS VLTDGQFFKG SFHDLQTARE ESNIPLLCKD FIIDKIQIDR 130 140 150 160 170 180 AYEAGADIIL LIVAALTKEK LKELYSYVLE KGLEVIVEVH DEQELETAIV LNPHVIGINN 190 200 210 220 230 240 RNLKTFEVDL SQTEKLGKRL NEEKLLWISE SGIHSKEDII RVKRAGAKGV LVGEALMTSS 250 SISSFFEDCK VNI

References

[1]	"Genome sequence of Bacillus cereus B4264." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B4264.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001176 Genomic DNA. Translation: ACK60144.1.
RefSeq	YP_002366026.1. NC_011725.1.
3D structure databases
ProteinModelPortal	B7HGZ9.
ModBase	Search...
Protein-protein interaction databases
STRING	B7HGZ9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000112612; EBBACP00000105213; EBBACG00000112605.
GeneID	7100911.
GenomeReviews	Gene locus BCB4264_A1294 in contig CP001176_GR.
KEGG	bcb:BCB4264_A1294.
PATRIC	18874545. VBIBacCer117876_1182.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000001798.
HOGENOM	HBG540956.
OMA	VESLGMT.
ProtClustDB	PRK00278.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_BACC4

Accession

Primary (citable) accession number: B7HGZ9

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program