B7HBA0 (GCST_BACC4) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Aminomethyltransferase
EC=2.1.2.10

Alternative name(s):
Glycine cleavage system T protein

Gene names

Name:	gcvT
Ordered Locus Names:	BCB4264_A4339

Organism

Bacillus cereus (strain B4264) [Complete proteome] [HAMAP]

Taxonomic identifier

405532 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Bacillaceae › Bacillus › Bacillus cereus group

Protein attributes

Sequence length	366 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	The glycine cleavage system catalyzes the degradation of glycine By similarity. HAMAP MF_00259
Catalytic activity	[Protein]-S(8)-aminomethyldihydrolipoyllysine + tetrahydrofolate = [protein]-dihydrolipoyllysine + 5,10-methylenetetrahydrofolate + NH3. HAMAP MF_00259
Subunit structure	The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.
Sequence similarities	Belongs to the GcvT family.

Ontologies

Keywords
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine catabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	aminomethyltransferase activity Inferred from electronic annotation. Source: EC transaminase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 366	366	Aminomethyltransferase HAMAP MF_00259		PRO_1000119195

Sequences

	Sequence		Length	Mass (Da)
	B7HBA0 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: F4796FC48A88D3C8	FASTA	366	40,239
	10 20 30 40 50 60 MITLQRTPLF DVYAKYGGKT IDFGGWELPV QFSSIKEEHE AVRTAAGLFD VSHMGEVEVK 70 80 90 100 110 120 GVDSLAFLQR VVTNDVSTLK VGGAQYTAMC YENGGTVDDL LIYKRGEEDY LLVINASNIE 130 140 150 160 170 180 KDYEWLASHV IGDATVVNVS SEVAQLAIQG PKAEGILQKV VSEDLKEIKF FKFKKDILVD 190 200 210 220 230 240 GIPALVSRTG YTGEDGFEIY CKSEDAAKLW EKLLEVGAEE GLKACGLGAR DTLRFEATLP 250 260 270 280 290 300 LYGQELSKDI TPIEAGIGFA VKTNKEADFF GKATLKEQKE NGAPRKLVGI EVIERGIPRT 310 320 330 340 350 360 HYPVFIGEEK IGEVTSGTQS PTLKKSIGLA LIDVKYAAVD TEVEIEIRNK RVKAVVVPTP FYKRSK

References

[1]	"Genome sequence of Bacillus cereus B4264." Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G. Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: B4264.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001176 Genomic DNA. Translation: ACK62772.1.
RefSeq	YP_002369032.1. NC_011725.1.
3D structure databases
ProteinModelPortal	B7HBA0.
ModBase	Search...
Protein-protein interaction databases
STRING	B7HBA0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	EBBACT00000112087; EBBACP00000105791; EBBACG00000112080.
GeneID	7096352.
GenomeReviews	Gene locus BCB4264_A4339 in contig CP001176_GR.
KEGG	bcb:BCB4264_A4339.
PATRIC	18880573. VBIBacCer117876_4193.
Organism-specific databases
CMR	Search...
Phylogenomic databases
GeneTree	EBGT00050000001932.
HOGENOM	HBG299834.
OMA	VINASNK.
ProtClustDB	PRK00389.
Family and domain databases
HAMAP	MF_00259. GcvT. [Tree]
InterPro	IPR013977. GCV_T_C. IPR006222. GCV_T_N. IPR006223. GcvT. IPR022903. NH2_Me_Trfase. [Graphical view]
KO	K00605.
PANTHER	PTHR13847:SF5. PTHR13847:SF5. 1 hit.
Pfam	PF01571. GCV_T. 1 hit. PF08669. GCV_T_C. 1 hit. [Graphical view]
PIRSF	PIRSF006487. GcvT. 1 hit.
TIGRFAMs	TIGR00528. GcvT. 1 hit.
ProtoNet	Search...

Entry information

Entry name

GCST_BACC4

Accession

Primary (citable) accession number: B7HBA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program