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B7H7H4

- THIM_BACC4

UniProt

B7H7H4 - THIM_BACC4

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Protein

Hydroxyethylthiazole kinase

Gene
thiM, BCB4264_A0439
Organism
Bacillus cereus (strain B4264)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei45 – 451Substrate; via amide nitrogen By similarity
Binding sitei121 – 1211ATP By similarity
Binding sitei167 – 1671ATP By similarity
Binding sitei194 – 1941Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-KW
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBCER405532:GI1K-437-MONOMER.
UniPathwayiUPA00060; UER00139.

Names & Taxonomyi

Protein namesi
Recommended name:
Hydroxyethylthiazole kinase (EC:2.7.1.50)
Alternative name(s):
4-methyl-5-beta-hydroxyethylthiazole kinase
Short name:
TH kinase
Short name:
Thz kinase
Gene namesi
Name:thiM
Ordered Locus Names:BCB4264_A0439
OrganismiBacillus cereus (strain B4264)
Taxonomic identifieri405532 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000007096: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 269269Hydroxyethylthiazole kinaseUniRule annotationPRO_1000198107Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi405532.BCB4264_A0439.

Structurei

3D structure databases

ProteinModelPortaliB7H7H4.

Family & Domainsi

Sequence similaritiesi

Belongs to the Thz kinase family.

Phylogenomic databases

eggNOGiCOG2145.
HOGENOMiHOG000114352.
KOiK00878.
OMAiQTFTANV.
OrthoDBiEOG628F8M.

Family and domain databases

Gene3Di3.40.1190.20. 1 hit.
HAMAPiMF_00228. Thz_kinase.
InterProiIPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view]
PfamiPF02110. HK. 1 hit.
[Graphical view]
PIRSFiPIRSF000513. Thz_kinase. 1 hit.
PRINTSiPR01099. HYETHTZKNASE.
SUPFAMiSSF53613. SSF53613. 1 hit.
TIGRFAMsiTIGR00694. thiM. 1 hit.

Sequencei

Sequence statusi: Complete.

B7H7H4-1 [UniParc]FASTAAdd to Basket

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MNLKEFSKVV DLVRESNPLV HNITNVVVTN FTANGLLALG ASPVMAYAKE    50
EVAEMASIAG ALVLNMGTLR PEEVEAMLLA GKSANANNVP VLFDPVGAGA 100
TSYRTEVARH IPAEIDLAII RGNAAEIANV INEKWEIKGV DAGTGNGDVV 150
SIARQAADEL NTVAVITGKE DVVTDGERTI VIRNGHPILT KVTGTGCLLT 200
SVIGAFVAVE KDYVKAAVAA LTFYGVASEL AAAKTVEKGP GSFQIEFLNQ 250
LANTTSGDIE KYGKIEELE 269
Length:269
Mass (Da):28,249
Last modified:February 10, 2009 - v1
Checksum:i084274B15BF00C52
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001176 Genomic DNA. Translation: ACK62832.1.
RefSeqiYP_002365218.1. NC_011725.1.

Genome annotation databases

EnsemblBacteriaiACK62832; ACK62832; BCB4264_A0439.
GeneIDi7098744.
KEGGibcb:BCB4264_A0439.
PATRICi18872841. VBIBacCer117876_0372.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001176 Genomic DNA. Translation: ACK62832.1 .
RefSeqi YP_002365218.1. NC_011725.1.

3D structure databases

ProteinModelPortali B7H7H4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405532.BCB4264_A0439.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK62832 ; ACK62832 ; BCB4264_A0439 .
GeneIDi 7098744.
KEGGi bcb:BCB4264_A0439.
PATRICi 18872841. VBIBacCer117876_0372.

Phylogenomic databases

eggNOGi COG2145.
HOGENOMi HOG000114352.
KOi K00878.
OMAi QTFTANV.
OrthoDBi EOG628F8M.

Enzyme and pathway databases

UniPathwayi UPA00060 ; UER00139 .
BioCyci BCER405532:GI1K-437-MONOMER.

Family and domain databases

Gene3Di 3.40.1190.20. 1 hit.
HAMAPi MF_00228. Thz_kinase.
InterProi IPR000417. Hyethyz_kinase.
IPR029056. Ribokinase-like.
[Graphical view ]
Pfami PF02110. HK. 1 hit.
[Graphical view ]
PIRSFi PIRSF000513. Thz_kinase. 1 hit.
PRINTSi PR01099. HYETHTZKNASE.
SUPFAMi SSF53613. SSF53613. 1 hit.
TIGRFAMsi TIGR00694. thiM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus B4264."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4264.

Entry informationi

Entry nameiTHIM_BACC4
AccessioniPrimary (citable) accession number: B7H7H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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