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Protein

Methylmalonate semialdehyde dehydrogenase [acylating]

Gene

iolA

Organism
Bacillus cereus (strain B4264)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.UniRule annotation

Catalytic activityi

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.UniRule annotation
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861NucleophileUniRule annotation
Binding sitei386 – 3861NADUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi178 – 1825NADUniRule annotation

GO - Molecular functioni

  1. malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBCER405532:GI1K-2302-MONOMER.
UniPathwayiUPA00076; UER00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonate semialdehyde dehydrogenase [acylating]UniRule annotation (EC:1.2.1.27UniRule annotation)
Short name:
MMSA dehydrogenaseUniRule annotation
Short name:
MMSDHUniRule annotation
Short name:
MSDHUniRule annotation
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating]UniRule annotation (EC:1.2.1.18UniRule annotation)
Short name:
MSA dehydrogenaseUniRule annotation
Gene namesi
Name:iolAUniRule annotation
Ordered Locus Names:BCB4264_A2320
OrganismiBacillus cereus (strain B4264)
Taxonomic identifieri405532 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000007096: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Methylmalonate semialdehyde dehydrogenase [acylating]PRO_1000187312Add
BLAST

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi405532.BCB4264_A2320.

Structurei

3D structure databases

ProteinModelPortaliB7H597.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family. IolA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271507.
KOiK00140.
OMAiYIYSTGC.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_01670. IolA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERiPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7H597-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MITTEIKRVK NHINGEWVES TGTEVEAVPN PATGKIIAYV PLSPKEDVEK
60 70 80 90 100
AVEAAKAAFE TWSKVPVPNR SRNLYKYLQL LQENKDELAK IITLENGKTL
110 120 130 140 150
TDATGEVQRG IEAVELATST PNLMMGQALP NIASGIDGSI WRYPIGVVAG
160 170 180 190 200
ITPFNFPMMI PLWMFPLAIA CGNTFVLKTS ERTPLLAERL VELFYEAGFP
210 220 230 240 250
KGVLNLVQGG KDVVNSILEN KDIQAVSFVG SEPVARYVYE TGTKHGKRVQ
260 270 280 290 300
ALAGAKNHAI VMPDCNLEKT VQGVIGSAFA SSGERCMACS VVAVVDEIAD
310 320 330 340 350
EFIDVLVAET KKLKVGDGFN EDNYVGPLIR ESHKERVLGY INSGVADGAT
360 370 380 390 400
LLVDGRKINE EVGEGYFVGA TIFDGVNQEM KIWQDEIFAP VLSIVRVKDL
410 420 430 440 450
EEGIKLTNQS KFANGAVIYT SNGKHAQTFR DNIDAGMIGV NVNVPAPMAF
460 470 480
FAFAGNKASF FGDLGTNGTD GVQFYTRKKV VTERWF
Length:486
Mass (Da):52,924
Last modified:February 10, 2009 - v1
Checksum:i82FC20D727FE62FA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001176 Genomic DNA. Translation: ACK61889.1.
RefSeqiYP_002367037.1. NC_011725.1.

Genome annotation databases

EnsemblBacteriaiACK61889; ACK61889; BCB4264_A2320.
GeneIDi7097431.
KEGGibcb:BCB4264_A2320.
PATRICi18876567. VBIBacCer117876_2192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001176 Genomic DNA. Translation: ACK61889.1.
RefSeqiYP_002367037.1. NC_011725.1.

3D structure databases

ProteinModelPortaliB7H597.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi405532.BCB4264_A2320.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACK61889; ACK61889; BCB4264_A2320.
GeneIDi7097431.
KEGGibcb:BCB4264_A2320.
PATRICi18876567. VBIBacCer117876_2192.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271507.
KOiK00140.
OMAiYIYSTGC.
OrthoDBiEOG6BS8QW.

Enzyme and pathway databases

UniPathwayiUPA00076; UER00148.
BioCyciBCER405532:GI1K-2302-MONOMER.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_01670. IolA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERiPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome sequence of Bacillus cereus B4264."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4264.

Entry informationi

Entry nameiIOLA_BACC4
AccessioniPrimary (citable) accession number: B7H597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.