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B7H597

- IOLA_BACC4

UniProt

B7H597 - IOLA_BACC4

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Protein

Methylmalonate semialdehyde dehydrogenase [acylating]

Gene
iolA, BCB4264_A2320
Organism
Bacillus cereus (strain B4264)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively By similarity.UniRule annotation

Catalytic activityi

3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.UniRule annotation
2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei286 – 2861Nucleophile By similarity
Binding sitei386 – 3861NAD By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi178 – 1825NAD By similarity

GO - Molecular functioni

  1. malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
  2. methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. inositol catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBCER405532:GI1K-2302-MONOMER.
UniPathwayiUPA00076; UER00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Methylmalonate semialdehyde dehydrogenase [acylating] (EC:1.2.1.27)
Short name:
MMSA dehydrogenase
Short name:
MMSDH
Short name:
MSDH
Alternative name(s):
Malonate semialdehyde dehydrogenase [acetylating] (EC:1.2.1.18)
Short name:
MSA dehydrogenase
Gene namesi
Name:iolA
Ordered Locus Names:BCB4264_A2320
OrganismiBacillus cereus (strain B4264)
Taxonomic identifieri405532 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
ProteomesiUP000007096: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 486486Methylmalonate semialdehyde dehydrogenase [acylating]UniRule annotationPRO_1000187312Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi405532.BCB4264_A2320.

Structurei

3D structure databases

ProteinModelPortaliB7H597.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271507.
KOiK00140.
OMAiGACLFDN.
OrthoDBiEOG6BS8QW.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPiMF_01670. IolA.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view]
PANTHERiPTHR11699:SF27. PTHR11699:SF27. 1 hit.
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR01722. MMSDH. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7H597-1 [UniParc]FASTAAdd to Basket

« Hide

MITTEIKRVK NHINGEWVES TGTEVEAVPN PATGKIIAYV PLSPKEDVEK    50
AVEAAKAAFE TWSKVPVPNR SRNLYKYLQL LQENKDELAK IITLENGKTL 100
TDATGEVQRG IEAVELATST PNLMMGQALP NIASGIDGSI WRYPIGVVAG 150
ITPFNFPMMI PLWMFPLAIA CGNTFVLKTS ERTPLLAERL VELFYEAGFP 200
KGVLNLVQGG KDVVNSILEN KDIQAVSFVG SEPVARYVYE TGTKHGKRVQ 250
ALAGAKNHAI VMPDCNLEKT VQGVIGSAFA SSGERCMACS VVAVVDEIAD 300
EFIDVLVAET KKLKVGDGFN EDNYVGPLIR ESHKERVLGY INSGVADGAT 350
LLVDGRKINE EVGEGYFVGA TIFDGVNQEM KIWQDEIFAP VLSIVRVKDL 400
EEGIKLTNQS KFANGAVIYT SNGKHAQTFR DNIDAGMIGV NVNVPAPMAF 450
FAFAGNKASF FGDLGTNGTD GVQFYTRKKV VTERWF 486
Length:486
Mass (Da):52,924
Last modified:February 10, 2009 - v1
Checksum:i82FC20D727FE62FA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001176 Genomic DNA. Translation: ACK61889.1.
RefSeqiYP_002367037.1. NC_011725.1.

Genome annotation databases

EnsemblBacteriaiACK61889; ACK61889; BCB4264_A2320.
GeneIDi7097431.
KEGGibcb:BCB4264_A2320.
PATRICi18876567. VBIBacCer117876_2192.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001176 Genomic DNA. Translation: ACK61889.1 .
RefSeqi YP_002367037.1. NC_011725.1.

3D structure databases

ProteinModelPortali B7H597.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 405532.BCB4264_A2320.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACK61889 ; ACK61889 ; BCB4264_A2320 .
GeneIDi 7097431.
KEGGi bcb:BCB4264_A2320.
PATRICi 18876567. VBIBacCer117876_2192.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271507.
KOi K00140.
OMAi GACLFDN.
OrthoDBi EOG6BS8QW.

Enzyme and pathway databases

UniPathwayi UPA00076 ; UER00148 .
BioCyci BCER405532:GI1K-2302-MONOMER.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
HAMAPi MF_01670. IolA.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR010061. MeMal-semiAld_DH.
IPR023510. MeMal-semiAld_DH_GmP_bac.
[Graphical view ]
PANTHERi PTHR11699:SF27. PTHR11699:SF27. 1 hit.
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR01722. MMSDH. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genome sequence of Bacillus cereus B4264."
    Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
    Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: B4264.

Entry informationi

Entry nameiIOLA_BACC4
AccessioniPrimary (citable) accession number: B7H597
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: June 11, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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