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B7H597

- IOLA_BACC4

UniProt

B7H597 - IOLA_BACC4

Protein

Methylmalonate semialdehyde dehydrogenase [acylating]

Gene

iolA

Organism
Bacillus cereus (strain B4264)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 43 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts malonate semialdehyde (MSA) and methylmalonate semialdehyde (MMSA) into acetyl-CoA and propanoyl-CoA, respectively.UniRule annotation

    Catalytic activityi

    3-oxopropanoate + CoA + NAD(P)+ = acetyl-CoA + CO2 + NAD(P)H.UniRule annotation
    2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = propanoyl-CoA + HCO3- + NADH.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei286 – 2861NucleophileUniRule annotation
    Binding sitei386 – 3861NADUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi178 – 1825NADUniRule annotation

    GO - Molecular functioni

    1. malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB-HAMAP
    2. methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. inositol catabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciBCER405532:GI1K-2302-MONOMER.
    UniPathwayiUPA00076; UER00148.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Methylmalonate semialdehyde dehydrogenase [acylating]UniRule annotation (EC:1.2.1.27UniRule annotation)
    Short name:
    MMSA dehydrogenaseUniRule annotation
    Short name:
    MMSDHUniRule annotation
    Short name:
    MSDHUniRule annotation
    Alternative name(s):
    Malonate semialdehyde dehydrogenase [acetylating]UniRule annotation (EC:1.2.1.18UniRule annotation)
    Short name:
    MSA dehydrogenaseUniRule annotation
    Gene namesi
    Name:iolAUniRule annotation
    Ordered Locus Names:BCB4264_A2320
    OrganismiBacillus cereus (strain B4264)
    Taxonomic identifieri405532 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillusBacillus cereus group
    ProteomesiUP000007096: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 486486Methylmalonate semialdehyde dehydrogenase [acylating]PRO_1000187312Add
    BLAST

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi405532.BCB4264_A2320.

    Structurei

    3D structure databases

    ProteinModelPortaliB7H597.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family. IolA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271507.
    KOiK00140.
    OMAiGACLFDN.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_01670. IolA.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010061. MeMal-semiAld_DH.
    IPR023510. MeMal-semiAld_DH_GmP_bac.
    [Graphical view]
    PANTHERiPTHR11699:SF27. PTHR11699:SF27. 1 hit.
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01722. MMSDH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7H597-1 [UniParc]FASTAAdd to Basket

    « Hide

    MITTEIKRVK NHINGEWVES TGTEVEAVPN PATGKIIAYV PLSPKEDVEK    50
    AVEAAKAAFE TWSKVPVPNR SRNLYKYLQL LQENKDELAK IITLENGKTL 100
    TDATGEVQRG IEAVELATST PNLMMGQALP NIASGIDGSI WRYPIGVVAG 150
    ITPFNFPMMI PLWMFPLAIA CGNTFVLKTS ERTPLLAERL VELFYEAGFP 200
    KGVLNLVQGG KDVVNSILEN KDIQAVSFVG SEPVARYVYE TGTKHGKRVQ 250
    ALAGAKNHAI VMPDCNLEKT VQGVIGSAFA SSGERCMACS VVAVVDEIAD 300
    EFIDVLVAET KKLKVGDGFN EDNYVGPLIR ESHKERVLGY INSGVADGAT 350
    LLVDGRKINE EVGEGYFVGA TIFDGVNQEM KIWQDEIFAP VLSIVRVKDL 400
    EEGIKLTNQS KFANGAVIYT SNGKHAQTFR DNIDAGMIGV NVNVPAPMAF 450
    FAFAGNKASF FGDLGTNGTD GVQFYTRKKV VTERWF 486
    Length:486
    Mass (Da):52,924
    Last modified:February 10, 2009 - v1
    Checksum:i82FC20D727FE62FA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001176 Genomic DNA. Translation: ACK61889.1.
    RefSeqiYP_002367037.1. NC_011725.1.

    Genome annotation databases

    EnsemblBacteriaiACK61889; ACK61889; BCB4264_A2320.
    GeneIDi7097431.
    KEGGibcb:BCB4264_A2320.
    PATRICi18876567. VBIBacCer117876_2192.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001176 Genomic DNA. Translation: ACK61889.1 .
    RefSeqi YP_002367037.1. NC_011725.1.

    3D structure databases

    ProteinModelPortali B7H597.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 405532.BCB4264_A2320.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACK61889 ; ACK61889 ; BCB4264_A2320 .
    GeneIDi 7097431.
    KEGGi bcb:BCB4264_A2320.
    PATRICi 18876567. VBIBacCer117876_2192.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271507.
    KOi K00140.
    OMAi GACLFDN.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00076 ; UER00148 .
    BioCyci BCER405532:GI1K-2302-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_01670. IolA.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR010061. MeMal-semiAld_DH.
    IPR023510. MeMal-semiAld_DH_GmP_bac.
    [Graphical view ]
    PANTHERi PTHR11699:SF27. PTHR11699:SF27. 1 hit.
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01722. MMSDH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genome sequence of Bacillus cereus B4264."
      Dodson R.J., Durkin A.S., Rosovitz M.J., Rasko D.A., Hoffmaster A., Ravel J., Sutton G.
      Submitted (OCT-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: B4264.

    Entry informationi

    Entry nameiIOLA_BACC4
    AccessioniPrimary (citable) accession number: B7H597
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 43 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3