B7H2H4 (G6PI_ACIB3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	ABBFA_003447

Organism

Acinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]

Taxonomic identifier

557600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000125680
Sites
	Active site	391	1	By similarity
	Active site	519	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7H2H4 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 8AB685520495C730	FASTA	555	62,863
	10 20 30 40 50 60 MSKSIEQFPK DLSSPLIQLK SSVEKNSKLH IKELFALEPE RFQNYSVKFD QLFFDYSKQR 70 80 90 100 110 120 ITKNILEQLV ALANNKQLTQ WINRLFSQDK INCTEQREAM HWALRLPSEY SKFPELTKQV 130 140 150 160 170 180 HIQLQRMYTL VEKIHAGQYR GATGEVIQDV VNIGVGGSDL GPHMVTHALA DFKVKTAKPL 190 200 210 220 230 240 NVHFVSTMDG SQLSDLLHQL RPETTLFIIS SKSFGTIDTL SNAQTVRQWL EKALGKHDRV 250 260 270 280 290 300 VKSHFIGVST KAEKMNEWGI APDNQLLLWD WVGGRYSLWS CIGFPIALTI GIDGFQQLLA 310 320 330 340 350 360 GAHAVDEHFQ NTSFERNIPV LMALLGIWNN NFLNIQTHAV LPYDGRLKYL AAYLQQLEME 370 380 390 400 410 420 SNGKSVQRDG QKVELDTCPI VWGEVGPNAQ HAFYQLLHQG TQAVSCDFIA PIQRYNADHF 430 440 450 460 470 480 TYVENAEALI EQHHLALSNC LAQSRLLAFG NEALDVKELE KLPIYKQYEG NQPSSTLLLD 490 500 510 520 530 540 ELNPYNLGML IALYEHKVFV QSVIWNINPF DQWGVEKGKQ IANQLLPILN GAQNDLSTLD 550 ASTRGLIKIL LGKAE

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB307-0294.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001172 Genomic DNA. Translation: ACJ57888.1.
RefSeq	YP_002327319.1. NC_011595.1.
3D structure databases
ProteinModelPortal	B7H2H4.
ModBase	Search...
Protein-protein interaction databases
STRING	B7H2H4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7057727.
GenomeReviews	Gene locus ABBFA_003447 in contig CP001172_GR.
KEGG	abb:ABBFA_003447.
PATRIC	20708359. VBIAciBau42682_3326.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	ASIWDIN.
ProtClustDB	PRK00179.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ACIB3

Accession

Primary (citable) accession number: B7H2H4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 18 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program