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Protein

Fatty acid oxidation complex subunit alpha

Gene

fadB

Organism
Acinetobacter baumannii (strain AB307-0294)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the aerobic and anaerobic degradation of long-chain fatty acids via beta-oxidation cycle. Catalyzes the formation of 3-oxoacyl-CoA from enoyl-CoA via L-3-hydroxyacyl-CoA. It can also use D-3-hydroxyacyl-CoA and cis-3-enoyl-CoA as substrate.UniRule annotation

Catalytic activityi

(S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH.UniRule annotation
(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O.UniRule annotation
(S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA.UniRule annotation
A (3Z)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.UniRule annotation
A (3E)-alk-3-enoyl-CoA = a (2E)-alk-2-enoyl-CoA.UniRule annotation

Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei120Important for catalytic activityUniRule annotation1
Sitei140Important for catalytic activityUniRule annotation1
Binding sitei298SubstrateUniRule annotation1
Binding sitei326NAD; via amide nitrogenUniRule annotation1
Binding sitei345NADUniRule annotation1
Binding sitei409NADUniRule annotation1
Binding sitei431NADUniRule annotation1
Active sitei452For 3-hydroxyacyl-CoA dehydrogenase activityUniRule annotation1
Binding sitei455NADUniRule annotation1
Binding sitei502SubstrateUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi402 – 404NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase, Lyase, Multifunctional enzyme, Oxidoreductase
Biological processFatty acid metabolism, Lipid degradation, Lipid metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00659

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acid oxidation complex subunit alphaUniRule annotation
Including the following 2 domains:
Enoyl-CoA hydratase/Delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase/3-hydroxybutyryl-CoA epimeraseUniRule annotation (EC:4.2.1.17UniRule annotation, EC:5.1.2.3UniRule annotation, EC:5.3.3.8UniRule annotation)
3-hydroxyacyl-CoA dehydrogenaseUniRule annotation (EC:1.1.1.35UniRule annotation)
Gene namesi
Name:fadBUniRule annotation
Ordered Locus Names:ABBFA_003230
OrganismiAcinetobacter baumannii (strain AB307-0294)
Taxonomic identifieri557600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001860261 – 717Fatty acid oxidation complex subunit alphaAdd BLAST717

Interactioni

Subunit structurei

Heterotetramer of two alpha chains (FadB) and two beta chains (FadA).UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB7H1I0
SMRiB7H1I0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 190Enoyl-CoA hydratase/isomeraseUniRule annotationAdd BLAST190
Regioni313 – 7173-hydroxyacyl-CoA dehydrogenaseUniRule annotationAdd BLAST405

Sequence similaritiesi

In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family.UniRule annotation
In the C-terminal section; belongs to the 3-hydroxyacyl-CoA dehydrogenase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000261344
KOiK01825
OMAiDYKAKRQ

Family and domain databases

HAMAPiMF_01621 FadB, 1 hit
InterProiView protein in InterPro
IPR006180 3-OHacyl-CoA_DH_CS
IPR006176 3-OHacyl-CoA_DH_NAD-bd
IPR006108 3HC_DH_C
IPR008927 6-PGluconate_DH-like_C_sf
IPR029045 ClpP/crotonase-like_dom_sf
IPR018376 Enoyl-CoA_hyd/isom_CS
IPR001753 Enoyl-CoA_hydra/iso
IPR012799 FadB
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF00725 3HCDH, 1 hit
PF02737 3HCDH_N, 1 hit
PF00378 ECH_1, 1 hit
SUPFAMiSSF48179 SSF48179, 2 hits
SSF51735 SSF51735, 1 hit
SSF52096 SSF52096, 1 hit
TIGRFAMsiTIGR02437 FadB, 1 hit
PROSITEiView protein in PROSITE
PS00067 3HCDH, 1 hit
PS00166 ENOYL_COA_HYDRATASE, 1 hit

Sequencei

Sequence statusi: Complete.

B7H1I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHAGNAITV QMLADGIAEF RFDLQGESVN KFNRATIEDF KAAIAAVKAN
60 70 80 90 100
NDIKGLVVTS GKSTFIVGAD ITEFGQNFAQ GEKAIVDWLM PVHEIFNSFE
110 120 130 140 150
DLDLPKVAAI NGMALGGGFE MCLVCDYRVM SEAAQVGLPE IKLGIYPGFG
160 170 180 190 200
GSVRLSRLIG IDNAVEWMAM ATPKKPAAAL KDGAVDAVVA ADKLLDAATD
210 220 230 240 250
LVKQAISGRL NWKAKRQEKL EAVKLNPLEQ MMAFNTAKGA VLAKANPAQY
260 270 280 290 300
PAPKLLLDSL QAGASLARDE ALKAEAEGFA KAAVTPQAEA LIGLFINDQV
310 320 330 340 350
VKKASKQHEK GAHPVNQAAV LGAGIMGGGI AYQAASKGTP IIMKDIGNPQ
360 370 380 390 400
LALGMKEANN LLTKQVERKK MKPVQMGETL ARIRPTLSYE EFKEVDIVIE
410 420 430 440 450
AVTENPKVKE IVLAETEKNV RENTIIASNT STISITRLAK ALQRPENFVG
460 470 480 490 500
MHFFNPVHMM PLVEVIRGEK TSEEAIATTV VLAQKMGKTP IVVNDCPGFL
510 520 530 540 550
VNRVLFPYFG AFDLLVKDGA DFQQIDNVMS KFGWPMGPAY LIDVVGIDTG
560 570 580 590 600
VHGAEVMAEG FPDRMKPDYK GAIEAMYEAK RLGQKNDVGF YKYELDKKGK
610 620 630 640 650
KAKTVDPTAY EVIAPFVTGE KREFDNQEII DRMMLALCNE TVRCLEDNIV
660 670 680 690 700
ATASEADMAM IMGIGFPPFR GGPCRYIDQT GVAEYVALCD KYAHLGKAYE
710
APQMLRDMAA NNKKFYG
Length:717
Mass (Da):77,874
Last modified:February 10, 2009 - v1
Checksum:iC8F7CAC439DE6C1B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001172 Genomic DNA Translation: ACJ56671.1
RefSeqiWP_000580942.1, NC_011595.1

Genome annotation databases

EnsemblBacteriaiACJ56671; ACJ56671; ABBFA_003230
KEGGiabb:ABBFA_003230

Similar proteinsi

Entry informationi

Entry nameiFADB_ACIB3
AccessioniPrimary (citable) accession number: B7H1I0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: April 25, 2018
This is version 66 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health