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B7H160

- THIM_ACIB3

UniProt

B7H160 - THIM_ACIB3

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Acinetobacter baumannii (strain AB307-0294)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei50 – 501Substrate; via amide nitrogenUniRule annotation
    Binding sitei126 – 1261ATPUniRule annotation
    Binding sitei171 – 1711ATPUniRule annotation
    Binding sitei200 – 2001Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciABAU557600:GKC3-1376-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:ABBFA_001371
    OrganismiAcinetobacter baumannii (strain AB307-0294)
    Taxonomic identifieri557600 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000006924: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 275275Hydroxyethylthiazole kinasePRO_0000383811Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557600.ABBFA_001371.

    Structurei

    3D structure databases

    ProteinModelPortaliB7H160.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiQTFTANV.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7H160-1 [UniParc]FASTAAdd to Basket

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    MNSTSNLIEQ VIEAWQNMQA KTPLVQCITN SVAANYTANV LLASGASPAM    50
    IDNPYEAESF TKISSALSIN LGTPTSEQMQ AMQISAKTAQ LNNVPWVLDP 100
    VGYGPILAWR SQMTDELLQF KPSVIRGNAS EISTLAGNQV QSKGVDSTLS 150
    SDQAYQQAFS LLTHASCIAI SGESDYILSN EVDAVIQVNG GSPLQPKITA 200
    TGCALGALIA AYSAVTTPTI AALSAHIHFA IAGKLAANQA QTMGSFSSIF 250
    MDYIHMLDAN LIEQYADVKL LNKQA 275
    Length:275
    Mass (Da):29,148
    Last modified:February 10, 2009 - v1
    Checksum:i2036927450642BCA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001172 Genomic DNA. Translation: ACJ58319.1.
    RefSeqiYP_002325274.1. NC_011595.1.

    Genome annotation databases

    EnsemblBacteriaiACJ58319; ACJ58319; ABBFA_001371.
    GeneIDi7058113.
    KEGGiabb:ABBFA_001371.
    PATRICi20704258. VBIAciBau42682_1315.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001172 Genomic DNA. Translation: ACJ58319.1 .
    RefSeqi YP_002325274.1. NC_011595.1.

    3D structure databases

    ProteinModelPortali B7H160.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557600.ABBFA_001371.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ58319 ; ACJ58319 ; ABBFA_001371 .
    GeneIDi 7058113.
    KEGGi abb:ABBFA_001371.
    PATRICi 20704258. VBIAciBau42682_1315.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi QTFTANV.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci ABAU557600:GKC3-1376-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AB307-0294.

    Entry informationi

    Entry nameiTHIM_ACIB3
    AccessioniPrimary (citable) accession number: B7H160
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3