B7H0U1 (RPPH_ACIB3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
RNA pyrophosphohydrolase
EC=3.6.1.-

Alternative name(s):
(Di)nucleoside polyphosphate hydrolase

Gene names

Name:	rppH
Synonyms:	nudH
Ordered Locus Names:	ABBFA_003123

Organism

Acinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]

Taxonomic identifier

557600 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex › Acinetobacter baumannii

Protein attributes

Sequence length	161 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage By similarity. HAMAP-Rule MF_00298
Cofactor	Divalent ions By similarity.
Sequence similarities	Belongs to the Nudix hydrolase family. RppH subfamily. Contains 1 nudix hydrolase domain.

Ontologies

Keywords
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 161	161	RNA pyrophosphohydrolase HAMAP-Rule MF_00298		PRO_1000119468
Regions
	Domain	6 – 149	144	Nudix hydrolase
	Motif	38 – 59	22	Nudix box HAMAP-Rule MF_00298

Sequences

	Sequence		Length	Mass (Da)
	B7H0U1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 4440C15AA26FDE24	FASTA	161	18,799
	10 20 30 40 50 60 MIDSEGFRPN VGIILANDDG QVLWAKRIGH NAWQFPQGGI QFGETPEQAL FRELREEIGL 70 80 90 100 110 120 LPEHVQIIAQ TKGWLRYRLP HRYIRSDSDP VCIGQKQKWF LLKLTAPAKN IQLNLADPPE 130 140 150 160 FDEWQWVSYW YPLGQVVNFK RDVYRKAMVE LCTQLPVQQL P

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB307-0294.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001172 Genomic DNA. Translation: ACJ58389.1.
RefSeq	YP_002327009.1. NC_011595.1.
3D structure databases
ProteinModelPortal	B7H0U1.
ModBase	Search...
Protein-protein interaction databases
STRING	557600.ABBFA_003123.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACJ58389; ACJ58389; ABBFA_003123.
GeneID	7057942.
KEGG	abb:ABBFA_003123.
PATRIC	20707710. VBIAciBau42682_3019.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0494.
HOGENOM	HOG000066723.
KO	K08311.
OMA	PEHVQIL.
ProtClustDB	PRK00714.
Enzyme and pathway databases
BioCyc	ABAU557600:GH0U-2396-MONOMER.
Family and domain databases
Gene3D	3.90.79.10. 1 hit.
HAMAP	MF_00298. Nudix_RppH.
InterPro	IPR020476. Nudix_hydrolase. IPR020084. NUDIX_hydrolase_CS. IPR000086. NUDIX_hydrolase_dom. IPR015797. NUDIX_hydrolase_dom-like. IPR022927. RppH. [Graphical view]
Pfam	PF00293. NUDIX. 1 hit. [Graphical view]
PRINTS	PR00502. NUDIXFAMILY.
SUPFAM	SSF55811. NUDIX_hydrolase. 1 hit.
PROSITE	PS51462. NUDIX. 1 hit. PS00893. NUDIX_BOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

RPPH_ACIB3

Accession

Primary (citable) accession number: B7H0U1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	May 1, 2013
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program