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B7H0P4

- TYSY_ACIB3

UniProt

B7H0P4 - TYSY_ACIB3

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Protein

Thymidylate synthase

Gene

thyA

Organism
Acinetobacter baumannii (strain AB307-0294)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Provides the sole de novo source of dTMP for DNA biosynthesis.UniRule annotation

Catalytic activityi

5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei162 – 1621UniRule annotation

GO - Molecular functioni

  1. thymidylate synthase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dTMP biosynthetic process Source: UniProtKB-HAMAP
  2. dTTP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Enzyme and pathway databases

BioCyciABAU557600:GKC3-3083-MONOMER.
UniPathwayiUPA00575.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate synthaseUniRule annotation (EC:2.1.1.45UniRule annotation)
Short name:
TSUniRule annotation
Short name:
TSaseUniRule annotation
Gene namesi
Name:thyAUniRule annotation
Ordered Locus Names:ABBFA_003076
OrganismiAcinetobacter baumannii (strain AB307-0294)
Taxonomic identifieri557600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000006924: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Thymidylate synthasePRO_1000197229Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi557600.ABBFA_003076.

Structurei

3D structure databases

ProteinModelPortaliB7H0P4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0207.
HOGENOMiHOG000257899.
KOiK00560.
OMAiDVHLYSN.
OrthoDBiEOG6K6V53.

Family and domain databases

Gene3Di3.30.572.10. 1 hit.
HAMAPiMF_00008. Thymidy_synth_bact.
InterProiIPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view]
PfamiPF00303. Thymidylat_synt. 1 hit.
[Graphical view]
PRINTSiPR00108. THYMDSNTHASE.
SUPFAMiSSF55831. SSF55831. 1 hit.
TIGRFAMsiTIGR03284. thym_sym. 1 hit.
PROSITEiPS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7H0P4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRAYLDLLQH ILDNGGDKGD RTGTGTRSVF GHQMRFDLSK GFPLLTTKKV
60 70 80 90 100
HFRSIVIELL WFLKGDTNVK YLQDNKVTIW DEWATAEQTA RFGRPEHELG
110 120 130 140 150
PVYGHQWRNF GATKNADGTY NQDGFDQIKW LINEIKTNPN SRRLIVSGWN
160 170 180 190 200
PNEAGQVALP PCHTLFQFFV QDNKLSCQLY QRSADVFLGV PFNIASYALL
210 220 230 240 250
THMIAQVCGL GVGDFVWTGG DTHLYANHFE QAKLQLTREP LPLCQLKLNP
260 270 280
EVKDIFDFKF EDIEIVGYES HPAIKAPVAV
Length:280
Mass (Da):31,826
Last modified:February 10, 2009 - v1
Checksum:i4BC33ECB88E38F86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001172 Genomic DNA. Translation: ACJ56883.1.
RefSeqiYP_002326962.1. NC_011595.1.

Genome annotation databases

EnsemblBacteriaiACJ56883; ACJ56883; ABBFA_003076.
GeneIDi7059209.
KEGGiabb:ABBFA_003076.
PATRICi20707618. VBIAciBau42682_2973.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001172 Genomic DNA. Translation: ACJ56883.1 .
RefSeqi YP_002326962.1. NC_011595.1.

3D structure databases

ProteinModelPortali B7H0P4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557600.ABBFA_003076.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ56883 ; ACJ56883 ; ABBFA_003076 .
GeneIDi 7059209.
KEGGi abb:ABBFA_003076.
PATRICi 20707618. VBIAciBau42682_2973.

Phylogenomic databases

eggNOGi COG0207.
HOGENOMi HOG000257899.
KOi K00560.
OMAi DVHLYSN.
OrthoDBi EOG6K6V53.

Enzyme and pathway databases

UniPathwayi UPA00575 .
BioCyci ABAU557600:GKC3-3083-MONOMER.

Family and domain databases

Gene3Di 3.30.572.10. 1 hit.
HAMAPi MF_00008. Thymidy_synth_bact.
InterProi IPR023451. Thymidate_synth/dCMP_Mease.
IPR000398. Thymidylate_synthase.
IPR020940. Thymidylate_synthase_AS.
[Graphical view ]
Pfami PF00303. Thymidylat_synt. 1 hit.
[Graphical view ]
PRINTSi PR00108. THYMDSNTHASE.
SUPFAMi SSF55831. SSF55831. 1 hit.
TIGRFAMsi TIGR03284. thym_sym. 1 hit.
PROSITEi PS00091. THYMIDYLATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AB307-0294.

Entry informationi

Entry nameiTYSY_ACIB3
AccessioniPrimary (citable) accession number: B7H0P4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3