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B7H051

- SYL_ACIB3

UniProt

B7H051 - SYL_ACIB3

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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acinetobacter baumannii (strain AB307-0294)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei639 – 6391ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABAU557600:GKC3-3022-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:ABBFA_003015
OrganismiAcinetobacter baumannii (strain AB307-0294)
Taxonomic identifieri557600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000006924: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874Leucine--tRNA ligasePRO_1000199170Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557600.ABBFA_003015.

Structurei

3D structure databases

ProteinModelPortaliB7H051.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi47 – 5711"HIGH" regionAdd
BLAST
Motifi636 – 6405"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiHISHELW.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7H051-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTISHIDPEY QANTIEPSVQ QDWENRKVFK VADTVEGKHR YILSMFPYPS
60 70 80 90 100
GKLHMGHVRN YTIGDVISRF YRLKGEAVLQ PMGWDAFGLP AENAAIAHKV
110 120 130 140 150
APAKWTFENI AYMRDQLKKL GLSVDWDREF ATCTPEYYHW EQWLFVQLYK
160 170 180 190 200
KGLIYRKLST VNWDPVDQTV LANEQVENGR GWRSGALVEK RDIPMYYFRI
210 220 230 240 250
TDYAQELLDD LDTLQDGWPQ QVLTMQRNWI GRSTGMEITF PSANTEIYAD
260 270 280 290 300
GLTVYTTRAD TLMGVTYVAV AAEHPLALKA AENNPELAAF IEECRMGSVA
310 320 330 340 350
EADLATAEKK GMATGLFVKH PVTGEELPVW IANYVLMSYG SGAVMAVPAH
360 370 380 390 400
DERDFEFANK FNLPIKQVID AKGADDADYS ATEWQEWYGS KEGKLVNSGE
410 420 430 440 450
FDGLEFQAAF DAFLAKLEPQ GLANSKVQFR LRDWGVSRQR YWGCPIPMIN
460 470 480 490 500
CDTCGQVTVP EDQLPVVLPT DVVPDGSGNP LNKMPEFYET KCPCCGGDAR
510 520 530 540 550
RETDTLDTFV ESSWYYARYA SPDFTGGMVK PEAAKNWLPV NQYIGGVEHA
560 570 580 590 600
ILHLLYARFF HKLMRDEGVV QGNEPFTNLL TQGMVLADTF YREAENGKKT
610 620 630 640 650
WFNPADIELE RDEKGRIISA KYSGDGQEVI IGGQEKMSKS KNNGIDPQAI
660 670 680 690 700
IDQYGADTAR VFMMFAAPPD QSLEWSDAGV EGANRFLKRV WRLVASFLEK
710 720 730 740 750
GNSATAIDKA NLSKDAQDLR RKTHETIQKV SDDIERRHAF NTAIAALMEL
760 770 780 790 800
LNASNKFEAK DDNDVAVERE AITTLLTLLA PFAPHLSQTL LAQFGTDLTE
810 820 830 840 850
ATFPEVDASA LTRNTQTIVV QVNGKLRGKL EVSVDISKDE LLAQAKALPE
860 870
VQQFLTGPTK KEIVVPNKLV NLVV
Length:874
Mass (Da):98,050
Last modified:February 10, 2009 - v1
Checksum:i4CC1532218E544EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001172 Genomic DNA. Translation: ACJ57618.1.
RefSeqiYP_002326901.1. NC_011595.1.

Genome annotation databases

EnsemblBacteriaiACJ57618; ACJ57618; ABBFA_003015.
GeneIDi7060271.
KEGGiabb:ABBFA_003015.
PATRICi20707498. VBIAciBau42682_2913.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001172 Genomic DNA. Translation: ACJ57618.1 .
RefSeqi YP_002326901.1. NC_011595.1.

3D structure databases

ProteinModelPortali B7H051.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 557600.ABBFA_003015.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ57618 ; ACJ57618 ; ABBFA_003015 .
GeneIDi 7060271.
KEGGi abb:ABBFA_003015.
PATRICi 20707498. VBIAciBau42682_2913.

Phylogenomic databases

eggNOGi COG0495.
HOGENOMi HOG000200747.
KOi K01869.
OMAi HISHELW.
OrthoDBi EOG63Z74X.

Enzyme and pathway databases

BioCyci ABAU557600:GKC3-3022-MONOMER.

Family and domain databases

Gene3Di 1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPi MF_00049_B. Leu_tRNA_synth_B.
InterProi IPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR015413. Methionyl/Leucyl_tRNA_Synth.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view ]
PANTHERi PTHR11946:SF7. PTHR11946:SF7. 1 hit.
Pfami PF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 2 hits.
PF13603. tRNA-synt_1_2. 1 hit.
PF09334. tRNA-synt_1g. 1 hit.
[Graphical view ]
PRINTSi PR00985. TRNASYNTHLEU.
SUPFAMi SSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsi TIGR00396. leuS_bact. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AB307-0294.

Entry informationi

Entry nameiSYL_ACIB3
AccessioniPrimary (citable) accession number: B7H051
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3