ID RNC_ACIB3 Reviewed; 230 AA. AC B7GYT0; DT 18-APR-2012, integrated into UniProtKB/Swiss-Prot. DT 18-APR-2012, sequence version 2. DT 08-NOV-2023, entry version 77. DE RecName: Full=Ribonuclease 3; DE EC=3.1.26.3; DE AltName: Full=Ribonuclease III; DE Short=RNase III; GN Name=rnc; OrderedLocusNames=ABBFA_000926; OS Acinetobacter baumannii (strain AB307-0294). OC Bacteria; Pseudomonadota; Gammaproteobacteria; Moraxellales; Moraxellaceae; OC Acinetobacter; Acinetobacter calcoaceticus/baumannii complex. OX NCBI_TaxID=557600; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AB307-0294; RX PubMed=18931120; DOI=10.1128/jb.00834-08; RA Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., RA MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., RA Bonomo R.A., Gill S.R.; RT "Comparative genome sequence analysis of multidrug-resistant Acinetobacter RT baumannii."; RL J. Bacteriol. 190:8053-8064(2008). CC -!- FUNCTION: Digests double-stranded RNA. Involved in the processing of CC primary rRNA transcript to yield the immediate precursors to the large CC and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when CC they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA CC of type II CRISPR loci if present in the organism (By similarity). CC {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=Endonucleolytic cleavage to 5'-phosphomonoester.; EC=3.1.26.3; CC -!- COFACTOR: CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; CC -!- SUBUNIT: Homodimer. {ECO:0000250}. CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. CC -!- SIMILARITY: Belongs to the ribonuclease III family. {ECO:0000305}. CC -!- SEQUENCE CAUTION: CC Sequence=ACJ56668.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001172; ACJ56668.1; ALT_INIT; Genomic_DNA. DR RefSeq; WP_000160699.1; NZ_CP001172.1. DR AlphaFoldDB; B7GYT0; -. DR SMR; B7GYT0; -. DR GeneID; 66396309; -. DR HOGENOM; CLU_000907_1_1_6; -. DR Proteomes; UP000006924; Chromosome. DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0004525; F:ribonuclease III activity; IEA:UniProtKB-UniRule. DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW. DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-UniRule. DR GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-UniRule. DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. DR CDD; cd10845; DSRM_RNAse_III_family; 1. DR CDD; cd00593; RIBOc; 1. DR Gene3D; 3.30.160.20; -; 1. DR Gene3D; 1.10.1520.10; Ribonuclease III domain; 1. DR HAMAP; MF_00104; RNase_III; 1. DR InterPro; IPR014720; dsRBD_dom. DR InterPro; IPR011907; RNase_III. DR InterPro; IPR000999; RNase_III_dom. DR InterPro; IPR036389; RNase_III_sf. DR NCBIfam; TIGR02191; RNaseIII; 1. DR PANTHER; PTHR14950; DICER-RELATED; 1. DR PANTHER; PTHR14950:SF37; ENDORIBONUCLEASE DICER; 1. DR Pfam; PF00035; dsrm; 1. DR Pfam; PF14622; Ribonucleas_3_3; 1. DR SMART; SM00358; DSRM; 1. DR SMART; SM00535; RIBOc; 1. DR SUPFAM; SSF54768; dsRNA-binding domain-like; 1. DR SUPFAM; SSF69065; RNase III domain-like; 1. DR PROSITE; PS50137; DS_RBD; 1. DR PROSITE; PS00517; RNASE_3_1; 1. DR PROSITE; PS50142; RNASE_3_2; 1. PE 3: Inferred from homology; KW Cytoplasm; Endonuclease; Hydrolase; Magnesium; Metal-binding; KW mRNA processing; Nuclease; RNA-binding; rRNA processing; rRNA-binding; KW tRNA processing. FT CHAIN 1..230 FT /note="Ribonuclease 3" FT /id="PRO_0000416602" FT DOMAIN 10..133 FT /note="RNase III" FT DOMAIN 161..230 FT /note="DRBM" FT ACT_SITE 50 FT /evidence="ECO:0000255" FT ACT_SITE 122 FT /evidence="ECO:0000250" FT BINDING 46 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000250" FT BINDING 119 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000250" FT BINDING 122 FT /ligand="Mg(2+)" FT /ligand_id="ChEBI:CHEBI:18420" FT /evidence="ECO:0000250" SQ SEQUENCE 230 AA; 26285 MW; 2AABC50C891B3120 CRC64; MTKHQFKLSD PRLLSRIGYQ FKQPELLQLA LTHRSVSHKY NYERLEFLGD SLLGMIIANY LYHAYPHENE GRLTRMRATL VRQEALGKIA TDLQLSRCLI LSTGELKSGG HHRESILADT VEAIIGAIYL DSSDLNLLKD IVLKWYTPYL DHIEPTDQLK DPKSRLQEYL QARKKPLPVY EVVDIQGDAP HQHFKVECLV DGLSKIHGEG SSRRFAEQAA AAEILKLLEQ //