B7GYK7 (ARGB_ACIB3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetylglutamate kinase
EC=2.7.2.8

Alternative name(s):
N-acetyl-L-glutamate 5-phosphotransferase
NAG kinase
Short name=AGK

Gene names

Name:	argB
Ordered Locus Names:	ABBFA_002726

Organism

Acinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]

Taxonomic identifier

557600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	302 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate. HAMAP MF_00082_B
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 2/4. HAMAP MF_00082_B
Subcellular location	Cytoplasm By similarity HAMAP MF_00082_B.
Sequence similarities	Belongs to the acetylglutamate kinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetylglutamate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 302	302	Acetylglutamate kinase HAMAP MF_00082_B		PRO_1000117112
Regions
	Region	68 – 69	2	Substrate binding By similarity
Sites
	Binding site	90	1	Substrate By similarity
	Binding site	194	1	Substrate By similarity
	Site	33	1	Transition state stabilizer By similarity
	Site	254	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7GYK7 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: E8C9B715C057FED5	FASTA	302	32,293
	10 20 30 40 50 60 MPQDQHLGVD KAKILIEALP YIQRFSGKTL VVKYGGNAMT DPELESSFAR DIVLLKTVGL 70 80 90 100 110 120 NPIVVHGGGP QVDSFLKQLG RESDRIDGMR VTDEATMEVV EMVLGGSVNK SIVNLINKHG 130 140 150 160 170 180 GRAIGLTGQD GNLLRARKLL MEKQEEDGSI KHIDLGMVGE VTGVKTDVLE MFTQSDFIPV 190 200 210 220 230 240 IAPLGVDEKG NTYNINADLV AGKVAEALGA EKLILLTNIS GVLDENKNLL TGLTTQEVDR 250 260 270 280 290 300 LIETGVIYGG MIPKVGCALD AVKGGVVSAH IVDGRVPHAT LLEIFTDHGV GTLISNRTQT TH

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB307-0294.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001172 Genomic DNA. Translation: ACJ58234.1.
RefSeq	YP_002326624.1. NC_011595.1.
3D structure databases
ProteinModelPortal	B7GYK7.
SMR	B7GYK7. Positions 12-297.
ModBase	Search...
Protein-protein interaction databases
STRING	B7GYK7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7057959.
GenomeReviews	Gene locus ABBFA_002726 in contig CP001172_GR.
KEGG	abb:ABBFA_002726.
PATRIC	20706915. VBIAciBau42682_2637.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG497643.
OMA	GGNAMID.
ProtClustDB	PRK00942.
Family and domain databases
HAMAP	MF_00082_B. ArgB_B. [Tree]
InterPro	IPR004662. AcgluKinase. IPR001048. Asp/Glu/Uridylate_kinase. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit.
KO	K00930.
Pfam	PF00696. AA_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000728. NAGK. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit.
TIGRFAMs	TIGR00761. ArgB. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ARGB_ACIB3

Accession

Primary (citable) accession number: B7GYK7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program