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B7GYG5 (BETA_ACIB3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 40. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Oxygen-dependent choline dehydrogenase

Short name=CDH
Short name=CHD
EC=1.1.99.1
Alternative name(s):
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8
Gene names
Name:betA
Ordered Locus Names:ABBFA_002684
OrganismAcinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]
Taxonomic identifier557600 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate By similarity. HAMAP-Rule MF_00750

Catalytic activity

Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP-Rule MF_00750

Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP-Rule MF_00750

Cofactor

FAD By similarity. HAMAP-Rule MF_00750

Pathway

Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP-Rule MF_00750

Sequence similarities

Belongs to the GMC oxidoreductase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Oxygen-dependent choline dehydrogenase HAMAP-Rule MF_00750
PRO_1000133315

Regions

Nucleotide binding7 – 3630FAD By similarity

Sites

Active site4771 By similarity

Sequences

Sequence LengthMass (Da)Tools
B7GYG5 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: B1B3FF7E0172F7FD

FASTA55261,302
        10         20         30         40         50         60 
MNIKEYDYII IGAGSAGNVL AARLTEDKDT TVLLLEAGGP DYRLDFRTQM PAALAYPLQG 

        70         80         90        100        110        120 
RRYNWAYLTD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNAMDLEQW ATHKGLENWT 

       130        140        150        160        170        180 
YADCLPYYKK AETRDIGGND YHGDSGPVSV ATPKNGNNVL FHAMVEAGVQ AGYPRTDDLN 

       190        200        210        220        230        240 
GYQQEGFGPM DRTVTPKGRR SSTARGYLDM AKGRPNLTIL THATTNKILF NQKQAIGVEY 

       250        260        270        280        290        300 
IIGADQNNLQ RALVKREVLL CAGAIASPQI LQRSGVGQST FLKSMDIDVV HDLPGVGENL 

       310        320        330        340        350        360 
QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFNGTG IGASNQFEAG GFIRSSDEFK 

       370        380        390        400        410        420 
WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGR IKLKSKDPFA HPSILFNYMS 

       430        440        450        460        470        480 
TEQDWREFRD AIRITREIMH QPALDPYRGD EISPGKHLQT DAELDDFVRN HAETAYHPSC 

       490        500        510        520        530        540 
SCKMGEDEMA VVDGQGRVHG MNGLRVVDAS IMPLIITGNL NATTIMIAEK IADQIRGREA 

       550 
LPRSTAPFYV AS 

« Hide

References

[1]"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii."
Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R.
J. Bacteriol. 190:8053-8064(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AB307-0294.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001172 Genomic DNA. Translation: ACJ57826.1.
RefSeqYP_002326582.1. NC_011595.1.

3D structure databases

ProteinModelPortalB7GYG5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING557600.ABBFA_002684.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACJ57826; ACJ57826; ABBFA_002684.
GeneID7060096.
KEGGabb:ABBFA_002684.
PATRIC20706830. VBIAciBau42682_2595.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG2303.
HOGENOMHOG000139600.
KOK00108.
OMAYLQYACT.
OrthoDBEOG67HJQP.

Enzyme and pathway databases

BioCycABAU557600:GKC3-2689-MONOMER.
UniPathwayUPA00529; UER00385.

Family and domain databases

HAMAPMF_00750. Choline_dehydrogen.
InterProIPR011533. Choline_dehydrogenase.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsTIGR01810. betA. 1 hit.
PROSITEPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBETA_ACIB3
AccessionPrimary (citable) accession number: B7GYG5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways