Reviewed, UniProtKB/Swiss-Prot B7GYG5 (BETA_ACIB3)

Names and origin

Protein names

Recommended name:
    Choline dehydrogenase
      Short name=CHD
      Short name=CDH
    EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	ABBFA_002684

Organism

Acinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]

Taxonomic identifier

557600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	552 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity.
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity.
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	FAD binding Inferred from electronic annotation. Source: InterPro choline dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 552	552	Choline dehydrogenase HAMAP MF_00750		PRO_1000133315
Regions
	Nucleotide binding	7 – 36	30	FAD Probable
Sites
	Active site	477	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B7GYG5-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: B1B3FF7E0172F7FD	FASTA	552	61,302
	10 20 30 40 50 60 MNIKEYDYII IGAGSAGNVL AARLTEDKDT TVLLLEAGGP DYRLDFRTQM PAALAYPLQG 70 80 90 100 110 120 RRYNWAYLTD PEPHMNNRRM ECGRGKGLGG SSLINGMCYI RGNAMDLEQW ATHKGLENWT 130 140 150 160 170 180 YADCLPYYKK AETRDIGGND YHGDSGPVSV ATPKNGNNVL FHAMVEAGVQ AGYPRTDDLN 190 200 210 220 230 240 GYQQEGFGPM DRTVTPKGRR SSTARGYLDM AKGRPNLTIL THATTNKILF NQKQAIGVEY 250 260 270 280 290 300 IIGADQNNLQ RALVKREVLL CAGAIASPQI LQRSGVGQST FLKSMDIDVV HDLPGVGENL 310 320 330 340 350 360 QDHLEMYLQY KCKQPVSLYP ALKWYNQPAI GAEWLFNGTG IGASNQFEAG GFIRSSDEFK 370 380 390 400 410 420 WPNIQYHFLP VAINYNGSNA VKEHGFQAHV GSMRSPSRGR IKLKSKDPFA HPSILFNYMS 430 440 450 460 470 480 TEQDWREFRD AIRITREIMH QPALDPYRGD EISPGKHLQT DAELDDFVRN HAETAYHPSC 490 500 510 520 530 540 SCKMGEDEMA VVDGQGRVHG MNGLRVVDAS IMPLIITGNL NATTIMIAEK IADQIRGREA 550 LPRSTAPFYV AS

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001172 Genomic DNA. Translation: ACJ57826.1.
RefSeq	YP_002326582.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7060096.
GenomeReviews	Gene locus ABBFA_002684 in contig CP001172_GR.
KEGG	abb:ABBFA_002684.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00750. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. betA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_ACIB3

Accession

Primary (citable) accession number: B7GYG5

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	September 22, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)