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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene

purM

Organism
Acinetobacter baumannii (strain AB307-0294)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciABAU557600:GKC3-881-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotation (EC:6.3.3.1UniRule annotation)
Alternative name(s):
AIR synthaseUniRule annotation
AIRSUniRule annotation
Phosphoribosyl-aminoimidazole synthetaseUniRule annotation
Gene namesi
Name:purMUniRule annotation
Ordered Locus Names:ABBFA_000875
OrganismiAcinetobacter baumannii (strain AB307-0294)
Taxonomic identifieri557600 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
ProteomesiUP000006924: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Phosphoribosylformylglycinamidine cyclo-ligasePRO_1000192982Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi557600.ABBFA_000875.

Structurei

3D structure databases

ProteinModelPortaliB7GY98.
SMRiB7GY98. Positions 10-356.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNHCVNDI.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B7GY98-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNSTSTPNT GLSYKDAGVD IEAGDALVDR IKSVAKRTTR PEVMGGLGGF
60 70 80 90 100
GALCKIPKGY EEPVLVSGTD GVGTKLRLAL NLNRHDTIGQ DLVAMCVNDL
110 120 130 140 150
LVCGAEPLFF LDYYATGHLN VDVAANVVTG IGKGCELAGC ALVGGETAEM
160 170 180 190 200
PGMYEGEDYD LAGFAVGVVE QSKIIDGSKV KSGDVLIGVA SSGAHSNGYS
210 220 230 240 250
LLRKILDVKN VDLTQVIDGR PLADVAMEPT RIYVKPVLEL CKQVDVHAMA
260 270 280 290 300
HITGGGLPGN LPRVLPNGAQ AVINEASWEW PELFKLLQRE GNVERFEMYR
310 320 330 340 350
TFNCGVGMVI AVDANDAEKA IEVLNAQGEK AWKIGHIQEN AESVEGADEK

IRVIFE
Length:356
Mass (Da):37,875
Last modified:February 10, 2009 - v1
Checksum:i9C790D38127F3C41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001172 Genomic DNA. Translation: ACJ58139.1.
RefSeqiYP_002324788.1. NC_011595.1.

Genome annotation databases

EnsemblBacteriaiACJ58139; ACJ58139; ABBFA_000875.
GeneIDi7057871.
KEGGiabb:ABBFA_000875.
PATRICi20703274. VBIAciBau42682_0833.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001172 Genomic DNA. Translation: ACJ58139.1.
RefSeqiYP_002324788.1. NC_011595.1.

3D structure databases

ProteinModelPortaliB7GY98.
SMRiB7GY98. Positions 10-356.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi557600.ABBFA_000875.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACJ58139; ACJ58139; ABBFA_000875.
GeneIDi7057871.
KEGGiabb:ABBFA_000875.
PATRICi20703274. VBIAciBau42682_0833.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiNHCVNDI.
OrthoDBiEOG61CM1V.

Enzyme and pathway databases

UniPathwayiUPA00074; UER00129.
BioCyciABAU557600:GKC3-881-MONOMER.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741. AIRS.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AB307-0294.

Entry informationi

Entry nameiPUR5_ACIB3
AccessioniPrimary (citable) accession number: B7GY98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 7, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.