Reviewed, UniProtKB/Swiss-Prot B7GY98 (PUR5_ACIB3)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	ABBFA_000875

Organism

Acinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]

Taxonomic identifier

557600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity HAMAP MF_00741.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_1000192982

Sequences

	Sequence		Length	Mass (Da)
	B7GY98-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 9C790D38127F3C41	FASTA	356	37,875
	10 20 30 40 50 60 MSNSTSTPNT GLSYKDAGVD IEAGDALVDR IKSVAKRTTR PEVMGGLGGF GALCKIPKGY 70 80 90 100 110 120 EEPVLVSGTD GVGTKLRLAL NLNRHDTIGQ DLVAMCVNDL LVCGAEPLFF LDYYATGHLN 130 140 150 160 170 180 VDVAANVVTG IGKGCELAGC ALVGGETAEM PGMYEGEDYD LAGFAVGVVE QSKIIDGSKV 190 200 210 220 230 240 KSGDVLIGVA SSGAHSNGYS LLRKILDVKN VDLTQVIDGR PLADVAMEPT RIYVKPVLEL 250 260 270 280 290 300 CKQVDVHAMA HITGGGLPGN LPRVLPNGAQ AVINEASWEW PELFKLLQRE GNVERFEMYR 310 320 330 340 350 TFNCGVGMVI AVDANDAEKA IEVLNAQGEK AWKIGHIQEN AESVEGADEK IRVIFE

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001172 Genomic DNA. Translation: ACJ58139.1.
RefSeq	YP_002324788.1.
3D structure databases
SMR	B7GY98. Positions 10-356.
ModBase	Search...
Genome annotation databases
GeneID	7057871.
GenomeReviews	Gene locus ABBFA_000875 in contig CP001172_GR.
KEGG	abb:ABBFA_000875.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG531222.
OMA	VHGLAHI.
Family and domain databases
HAMAP	MF_00741_B. AIRS_B. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. IPR016188. PurM_N-like. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ACIB3

Accession

Primary (citable) accession number: B7GY98

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	February 9, 2010
This is version 14 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)