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B7GY04

- ASPD_ACIB3

UniProt

B7GY04 - ASPD_ACIB3

Protein

Probable L-aspartate dehydrogenase

Gene

nadX

Organism
Acinetobacter baumannii (strain AB307-0294)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.UniRule annotation

    Catalytic activityi

    L-aspartate + H2O + NAD(P)+ = oxaloacetate + NH3 + NAD(P)H.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei120 – 1201NAD; via amide nitrogenUniRule annotation
    Binding sitei186 – 1861NADUniRule annotation
    Active sitei216 – 2161UniRule annotation

    GO - Molecular functioni

    1. aspartate dehydrogenase activity Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADP binding Source: UniProtKB-HAMAP
    4. oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-HAMAP
    2. NADP catabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Keywords - Ligandi

    NAD, NADP

    Enzyme and pathway databases

    BioCyciABAU557600:GKC3-2661-MONOMER.
    UniPathwayiUPA00253; UER00456.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable L-aspartate dehydrogenaseUniRule annotation (EC:1.4.1.21UniRule annotation)
    Gene namesi
    Name:nadXUniRule annotation
    Ordered Locus Names:ABBFA_002656
    OrganismiAcinetobacter baumannii (strain AB307-0294)
    Taxonomic identifieri557600 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000006924: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 263263Probable L-aspartate dehydrogenasePRO_1000140081Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi557600.ABBFA_002656.

    Structurei

    3D structure databases

    ProteinModelPortaliB7GY04.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the L-aspartate dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1712.
    HOGENOMiHOG000206326.
    KOiK06989.
    OMAiECAGHSA.
    OrthoDBiEOG6ND0JC.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_01265. NadX.
    InterProiIPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005227. Asp_dh_NAD_syn. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7GY04-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKKLMMIGFG AMAAEVYAHL PQDLQLKWIV VPSRSIEKVQ SQVSSDIQVI    50
    SDIEQCDGTP DYVIEVAGQA AVKEHAQKVL AKGWTIGLIS VGTLADSEFL 100
    VQLKQTAEKN DAHLHLLAGA IAGIDGISAA KEGGLQKVTY KGCKSPKSWK 150
    GSYAEQLVDL DHVSEPTVFF TGTAREAAMK FPANANVAAT IALAGLGMDE 200
    TMVELTVDPT INKNKHTIVA EGGFGQMTIE LVGVPLPSNP KTSTLAALSV 250
    IRACRNSVEA IQI 263
    Length:263
    Mass (Da):27,954
    Last modified:February 10, 2009 - v1
    Checksum:iA2F94A128F512144
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001172 Genomic DNA. Translation: ACJ56360.1.
    RefSeqiYP_002326554.1. NC_011595.1.

    Genome annotation databases

    EnsemblBacteriaiACJ56360; ACJ56360; ABBFA_002656.
    GeneIDi7058006.
    KEGGiabb:ABBFA_002656.
    PATRICi20706770. VBIAciBau42682_2565.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001172 Genomic DNA. Translation: ACJ56360.1 .
    RefSeqi YP_002326554.1. NC_011595.1.

    3D structure databases

    ProteinModelPortali B7GY04.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557600.ABBFA_002656.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ56360 ; ACJ56360 ; ABBFA_002656 .
    GeneIDi 7058006.
    KEGGi abb:ABBFA_002656.
    PATRICi 20706770. VBIAciBau42682_2565.

    Phylogenomic databases

    eggNOGi COG1712.
    HOGENOMi HOG000206326.
    KOi K06989.
    OMAi ECAGHSA.
    OrthoDBi EOG6ND0JC.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00456 .
    BioCyci ABAU557600:GKC3-2661-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_01265. NadX.
    InterProi IPR005106. Asp/hSer_DH_NAD-bd.
    IPR002811. Asp_DH.
    IPR020626. Asp_DH_prok.
    IPR011182. L-Asp_DH.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01958. DUF108. 1 hit.
    PF03447. NAD_binding_3. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005227. Asp_dh_NAD_syn. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AB307-0294.

    Entry informationi

    Entry nameiASPD_ACIB3
    AccessioniPrimary (citable) accession number: B7GY04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia.UniRule annotation

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3