B7GXE2 (UPPP_ACIB3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Undecaprenyl-diphosphatase
EC=3.6.1.27

Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase

Gene names

Name:	uppP
Ordered Locus Names:	ABBFA_000700

Organism

Acinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]

Taxonomic identifier

557600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter › Acinetobacter calcoaceticus/baumannii complex

Protein attributes

Sequence length	272 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity. HAMAP MF_01006
Catalytic activity	Undecaprenyl diphosphate + H2O = undecaprenyl phosphate + phosphate. HAMAP MF_01006
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_01006.
Miscellaneous	Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available. HAMAP MF_01006
Sequence similarities	Belongs to the UppP family.

Ontologies

Keywords
Biological process	Antibiotic resistance Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cellular cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW dephosphorylation Inferred from electronic annotation. Source: InterPro peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW response to antibiotic Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	undecaprenyl-diphosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 272	272	Undecaprenyl-diphosphatase HAMAP MF_01006		PRO_1000134671
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Transmembrane	43 – 63	21	Helical; Potential
	Transmembrane	86 – 106	21	Helical; Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Transmembrane	145 – 165	21	Helical; Potential
	Transmembrane	186 – 206	21	Helical; Potential
	Transmembrane	222 – 242	21	Helical; Potential
	Transmembrane	249 – 269	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	B7GXE2 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 1562D4CC13596C73	FASTA	272	29,506
	10 20 30 40 50 60 MENFEVIKAL FLGFVEGLTE FLPISSTGHL ILFGHIIDFH SDGGRVFEVV IQLGAILAVC 70 80 90 100 110 120 WLYRQKIINL IKGFFSGDVE SRHFAISVLI AFSPAVIIGV LAVDFIKSVL FSPIVVAIAL 130 140 150 160 170 180 IVGALIIFWV ESKQFEHKTD DATKITFKQA LLVGLAQCVA MIPGTSRSGA TIVGGMFAGL 190 200 210 220 230 240 SRKAATEFSF FLAMPTMLGA ATFDLIKNAD VLTSDNMVNI GVGFVAAFIA ALLVVKALVL 250 260 270 FVERHTLRVF AWYRIVLGVI ILIAAMFFNL SA

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AB307-0294.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001172 Genomic DNA. Translation: ACJ57867.1.
RefSeq	YP_002324618.1. NC_011595.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	B7GXE2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	7059220.
GenomeReviews	Gene locus ABBFA_000700 in contig CP001172_GR.
KEGG	abb:ABBFA_000700.
PATRIC	20702935. VBIAciBau42682_0669.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG391969.
OMA	WDKIMST.
ProtClustDB	PRK00281.
Family and domain databases
HAMAP	MF_01006. Undec_diphosphatase. [Tree]
InterPro	IPR003824. Bacitracin-R_BacA. [Graphical view]
KO	K06153.
Pfam	PF02673. BacA. 1 hit. [Graphical view]
TIGRFAMs	TIGR00753. Undec_PP_bacA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

UPPP_ACIB3

Accession

Primary (citable) accession number: B7GXE2

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	January 25, 2012
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program