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B7GW58

- MDH_ACIB3

UniProt

B7GW58 - MDH_ACIB3

Protein

Malate dehydrogenase

Gene

mdh

Organism
Acinetobacter baumannii (strain AB307-0294)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 41 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the reversible oxidation of malate to oxaloacetate.UniRule annotation

    Catalytic activityi

    (S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei94 – 941SubstrateUniRule annotation
    Binding sitei100 – 1001SubstrateUniRule annotation
    Binding sitei107 – 1071NADUniRule annotation
    Binding sitei114 – 1141NADUniRule annotation
    Binding sitei133 – 1331SubstrateUniRule annotation
    Binding sitei164 – 1641SubstrateUniRule annotation
    Active sitei189 – 1891Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi11 – 177NADUniRule annotation
    Nucleotide bindingi131 – 1333NADUniRule annotation

    GO - Molecular functioni

    1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cellular carbohydrate metabolic process Source: InterPro
    2. malate metabolic process Source: InterPro
    3. tricarboxylic acid cycle Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Tricarboxylic acid cycle

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BioCyciABAU557600:GKC3-494-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
    Gene namesi
    Name:mdhUniRule annotation
    Ordered Locus Names:ABBFA_000492
    OrganismiAcinetobacter baumannii (strain AB307-0294)
    Taxonomic identifieri557600 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesMoraxellaceaeAcinetobacterAcinetobacter calcoaceticus/baumannii complex
    ProteomesiUP000006924: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 328328Malate dehydrogenasePRO_1000191604Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi557600.ABBFA_000492.

    Structurei

    3D structure databases

    ProteinModelPortaliB7GW58.
    SMRiB7GW58. Positions 2-327.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the LDH/MDH superfamily. MDH type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0039.
    HOGENOMiHOG000220953.
    KOiK00024.
    OMAiAFSQECI.
    OrthoDBiEOG6PP9Q2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPiMF_01517. Malate_dehydrog_2.
    InterProiIPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23382. PTHR23382. 1 hit.
    PfamiPF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMiSSF56327. SSF56327. 1 hit.
    TIGRFAMsiTIGR01759. MalateDH-SF1. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7GW58-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKQPVRVAVT GAAGQIGYSL LFRIASGEML GKDQPVILQL LEVPVEKAQQ    50
    ALKGVMMELD DCAFPLLAGM IGTDDPKVAF KDADYALLVG SRPRGPGMER 100
    ADLLKVNGEI FIGQGQALNE VASRDVKVLV VGNPANTNAY IAMKSAPDLP 150
    AKNFTAMLRL DHNRALTQVA QKAGVAVADI EKLTVWGNHS PTMYADYRFA 200
    TANGESLKDK INDPAWNKDV FLPTVGKRGA AIIEARGLSS AASAANAAID 250
    HMRDWALGTN GKWVTMGVPS DGSYGIPEGV MFGFPVTTEN GEYKIVQGLE 300
    IDEFSRERIN FTLNELEEER AAIADMVK 328
    Length:328
    Mass (Da):35,323
    Last modified:February 10, 2009 - v1
    Checksum:i4A3ABDD04F615F6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001172 Genomic DNA. Translation: ACJ56558.1.
    RefSeqiYP_002324421.1. NC_011595.1.

    Genome annotation databases

    EnsemblBacteriaiACJ56558; ACJ56558; ABBFA_000492.
    GeneIDi7059678.
    KEGGiabb:ABBFA_000492.
    PATRICi20702505. VBIAciBau42682_0471.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001172 Genomic DNA. Translation: ACJ56558.1 .
    RefSeqi YP_002324421.1. NC_011595.1.

    3D structure databases

    ProteinModelPortali B7GW58.
    SMRi B7GW58. Positions 2-327.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 557600.ABBFA_000492.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ56558 ; ACJ56558 ; ABBFA_000492 .
    GeneIDi 7059678.
    KEGGi abb:ABBFA_000492.
    PATRICi 20702505. VBIAciBau42682_0471.

    Phylogenomic databases

    eggNOGi COG0039.
    HOGENOMi HOG000220953.
    KOi K00024.
    OMAi AFSQECI.
    OrthoDBi EOG6PP9Q2.

    Enzyme and pathway databases

    BioCyci ABAU557600:GKC3-494-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    3.90.110.10. 1 hit.
    HAMAPi MF_01517. Malate_dehydrog_2.
    InterProi IPR001557. L-lactate/malate_DH.
    IPR022383. Lactate/malate_DH_C.
    IPR001236. Lactate/malate_DH_N.
    IPR015955. Lactate_DH/Glyco_Ohase_4_C.
    IPR010945. Malate_DH_type2.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23382. PTHR23382. 1 hit.
    Pfami PF02866. Ldh_1_C. 1 hit.
    PF00056. Ldh_1_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
    SUPFAMi SSF56327. SSF56327. 1 hit.
    TIGRFAMsi TIGR01759. MalateDH-SF1. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AB307-0294.

    Entry informationi

    Entry nameiMDH_ACIB3
    AccessioniPrimary (citable) accession number: B7GW58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 41 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3