Reviewed, UniProtKB/Swiss-Prot B7GV10 (DAPB_ACIB3)

Names and origin

Protein names

Recommended name:
    Dihydrodipicolinate reductase
      Short name=DHPR
    EC=1.3.1.26

Gene names

Name:	dapB
Ordered Locus Names:	ABBFA_000038

Organism

Acinetobacter baumannii (strain AB307-0294) [Complete proteome] [HAMAP]

Taxonomic identifier

557600 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Moraxellaceae › Acinetobacter

Protein attributes

Sequence length	273 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2,3,4,5-tetrahydrodipicolinate + NAD(P)+ = 2,3-dihydrodipicolinate + NAD(P)H. HAMAP MF_00102
Pathway	Amino-acid biosynthesis; L-lysine biosynthesis via DAP pathway; (S)-tetrahydrodipicolinate from L-aspartate: step 4/4. HAMAP MF_00102
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the dihydrodipicolinate reductase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Diaminopimelate biosynthesis Lysine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	diaminopimelate biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	binding Inferred from electronic annotation. Source: InterPro dihydrodipicolinate reductase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 273	273	Dihydrodipicolinate reductase HAMAP MF_00102		PRO_1000117356

Sequences

	Sequence		Length	Mass (Da)
	B7GV10-1 [UniParc]. Last modified February 10, 2009. Version 1. Checksum: 5714FED42EC60F84	FASTA	273	28,753
	10 20 30 40 50 60 MSAAPRIGIL GAGGRMGRIL IQAVQQAGYQ LGAAVVRPES TLIGADAGEL AGIGSIGVKL 70 80 90 100 110 120 TGSLAEVLED CDVVIDFSTP AATSEHLKLC REAGVAIVIG TTGMSDEQKA ELDETAKHIP 130 140 150 160 170 180 VVYAANYSVG VNVSIKLLEL AAKVFGDTVD IEVIEAHHRH KVDAPSGTAL MMGEAIADTL 190 200 210 220 230 240 GRNLKEVAVY GREGHTGPRD RQTIGFETIR GGDIVGEHTV MFIGEGERVE VTHKATNRMN 250 260 270 FAAGAVRAAA WVVGREARKY DMKDVLGLND VQV

References

[1]

"Comparative genome sequence analysis of multidrug-resistant Acinetobacter baumannii." Adams M.D., Goglin K., Molyneaux N., Hujer K.M., Lavender H., Jamison J.J., MacDonald I.J., Martin K.M., Russo T., Campagnari A.A., Hujer A.M., Bonomo R.A., Gill S.R. J. Bacteriol. 190:8053-8064(2008) [PubMed: 18931120] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP001172 Genomic DNA. Translation: ACJ57507.1.
RefSeq	YP_002323979.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	7059336.
GenomeReviews	Gene locus ABBFA_000038 in contig CP001172_GR.
KEGG	abb:ABBFA_000038.
Organism-specific databases
CMR	Search...
Family and domain databases
HAMAP	MF_00102. [Tree]
InterPro	IPR000846. DapB. IPR011770. Dihydrodipicolinate_Rdtase. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 2 hits.
PANTHER	PTHR20836. DapB_bac/pln. 1 hit.
Pfam	PF05173. DapB_C. 1 hit. PF01113. DapB_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR00036. dapB. 1 hit.
PROSITE	PS01298. DAPB. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DAPB_ACIB3

Accession

Primary (citable) accession number: B7GV10

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 10, 2009
Last modified:	September 22, 2009
This is version 7 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)