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B7GUB8

- B7GUB8_BIFLS

UniProt

B7GUB8 - B7GUB8_BIFLS

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Protein

Alanine racemase

Gene
Blon_1997
Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Unreviewed - Annotation score: 2 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotations

Cofactori

Pyridoxal phosphate By similarity.UniRule annotationSAAS annotations

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei63 – 631Proton acceptor; specific for D-alanine By similarityUniRule annotation
Binding sitei165 – 1651Substrate By similarityUniRule annotation
Active sitei303 – 3031Proton acceptor; specific for L-alanine By similarityUniRule annotation
Binding sitei367 – 3671Substrate; via amide nitrogen By similarityUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotationsImported

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotations

Enzyme and pathway databases

BioCyciBLON391904:GCDR-2068-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Blon_1997Imported
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)Imported
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000001360: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei63 – 631N6-(pyridoxal phosphate)lysine By similarityUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi391904.Blon_1997.

Structurei

3D structure databases

ProteinModelPortaliB7GUB8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0787.
KOiK01775.
OMAiLWQLEAI.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7GUB8-1 [UniParc]FASTAAdd to Basket

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MSMNAAPEIA FSSERGKANY EAARRQYPAQ AIVNLKTMRD NMAHLVSVVG    50
GPTSGTAVMG VVKADAYGHG LLPTALAALA GGATWLGTAQ SHEALLLRRL 100
GIGPDRCHIL TWVYNGAAAP FDDLIAADID VSVGSLSGIE ALAAAARRLG 150
KPARVHVKVD SGFGRNGFTP AGFDAALAAL VPLAKEGVLR IVGQWSHLAV 200
ADSPDVPEFV ASTDQQIATF KDFTRRMELA GIPPEIRHLA NTAATLDRPE 250
IHFELTRPGI GLYGYEPDPA MGTPRDWHLT PAMRLQAQLG TVKDVEAGHG 300
ISYGRTYLTP DNTSTAIVPL GYADGIHRSA SGFDMEGAKH VEKPGGPVRI 350
MTAEGPRLYR VCGRVCMDQF IVDLHGSAAE LGVHEGDTVE LFGAGRGEDY 400
VEPTADDWAR AADTISYEIF TCLRNRIPRL YEQAADALPA ADLAKLDPAT 450
LL 452
Length:452
Mass (Da):48,122
Last modified:February 10, 2009 - v1
Checksum:i633DFAC4F745E8D7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ53064.1.
RefSeqiWP_012578270.1. NC_011593.1.
YP_002323442.1. NC_011593.1.

Genome annotation databases

EnsemblBacteriaiACJ53064; ACJ53064; Blon_1997.
GeneIDi7053651.
KEGGibln:Blon_1997.
PATRICi21125064. VBIBifLon71229_2010.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ53064.1 .
RefSeqi WP_012578270.1. NC_011593.1.
YP_002323442.1. NC_011593.1.

3D structure databases

ProteinModelPortali B7GUB8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391904.Blon_1997.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ53064 ; ACJ53064 ; Blon_1997 .
GeneIDi 7053651.
KEGGi bln:Blon_1997.
PATRICi 21125064. VBIBifLon71229_2010.

Phylogenomic databases

eggNOGi COG0787.
KOi K01775.
OMAi LWQLEAI.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .
BioCyci BLON391904:GCDR-2068-MONOMER.

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
    Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12 [JGI].

Entry informationi

Entry nameiB7GUB8_BIFLS
AccessioniPrimary (citable) accession number: B7GUB8
Entry historyi
Integrated into UniProtKB/TrEMBL: February 10, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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