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B7GU81

- PUR5_BIFLS

UniProt

B7GU81 - PUR5_BIFLS

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Protein

Phosphoribosylformylglycinamidine cyclo-ligase

Gene
purM, Blon_1959, BLIJ_2031
Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. phosphoribosylformylglycinamidine cyclo-ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' IMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Purine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON391904:GCDR-2029-MONOMER.
UniPathwayiUPA00074; UER00129.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoribosylformylglycinamidine cyclo-ligase (EC:6.3.3.1)
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene namesi
Name:purM
Ordered Locus Names:Blon_1959, BLIJ_2031
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000001360: Chromosome, UP000007256: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 345345Phosphoribosylformylglycinamidine cyclo-ligaseUniRule annotationPRO_1000148269Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391904.Blon_1959.

Structurei

3D structure databases

ProteinModelPortaliB7GU81.

Family & Domainsi

Sequence similaritiesi

Belongs to the AIR synthase family.

Phylogenomic databases

eggNOGiCOG0150.
HOGENOMiHOG000229090.
KOiK01933.
OMAiEFEMYRT.
OrthoDBiEOG61CM1V.

Family and domain databases

Gene3Di3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPiMF_00741_B. AIRS_B.
InterProiIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamiPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMiSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsiTIGR00878. purM. 1 hit.

Sequencei

Sequence statusi: Complete.

B7GU81-1 [UniParc]FASTAAdd to Basket

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MPKAYENAGV SVEAGYEVVK RIKSHVARTN RPGVVGGIGG FGGLFDLASL    50
GYKEPVLISG TDGVGTKLMV AKLANKHNTI GIDCVAMCVN DIAAQGAEPL 100
FFLDYIACGK NDPALLEQVV AGVADGCVQA GSALVGGETA EMPGMYDEDE 150
YDLAGFSIGV AEKSAIVDGS TIVEGDVLIG LPSTGVHSNG FSLVRKALFE 200
QAGYTVDTKL DELGGEKLGD VLLTPTKIYV KALSPLFKAG VVKGVAHITG 250
GGFIENIPRM IPDGLAAEIE LGTWPVLPIF DVLEKAGNID HKEMYNIFNM 300
GIGMVLAIDP ARKDEALKLL ADNNEPAYVL GQITADTTGT QIVLK 345
Length:345
Mass (Da):36,083
Last modified:February 10, 2009 - v1
Checksum:i8066301915716DE2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ53027.1.
AP010889 Genomic DNA. Translation: BAJ69609.1.
RefSeqiWP_012578234.1. NC_017219.1.
YP_002323405.1. NC_011593.1.
YP_005585779.1. NC_017219.1.

Genome annotation databases

EnsemblBacteriaiACJ53027; ACJ53027; Blon_1959.
BAJ69609; BAJ69609; BLIJ_2031.
GeneIDi12167684.
7053614.
KEGGibln:Blon_1959.
blon:BLIJ_2031.
PATRICi21124980. VBIBifLon71229_1969.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ53027.1 .
AP010889 Genomic DNA. Translation: BAJ69609.1 .
RefSeqi WP_012578234.1. NC_017219.1.
YP_002323405.1. NC_011593.1.
YP_005585779.1. NC_017219.1.

3D structure databases

ProteinModelPortali B7GU81.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391904.Blon_1959.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ53027 ; ACJ53027 ; Blon_1959 .
BAJ69609 ; BAJ69609 ; BLIJ_2031 .
GeneIDi 12167684.
7053614.
KEGGi bln:Blon_1959.
blon:BLIJ_2031.
PATRICi 21124980. VBIBifLon71229_1969.

Phylogenomic databases

eggNOGi COG0150.
HOGENOMi HOG000229090.
KOi K01933.
OMAi EFEMYRT.
OrthoDBi EOG61CM1V.

Enzyme and pathway databases

UniPathwayi UPA00074 ; UER00129 .
BioCyci BLON391904:GCDR-2029-MONOMER.

Family and domain databases

Gene3Di 3.30.1330.10. 1 hit.
3.90.650.10. 1 hit.
HAMAPi MF_00741_B. AIRS_B.
InterProi IPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view ]
Pfami PF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view ]
SUPFAMi SSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsi TIGR00878. purM. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
    Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.

Entry informationi

Entry nameiPUR5_BIFLS
AccessioniPrimary (citable) accession number: B7GU81
Secondary accession number(s): E8MM32
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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