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Protein

Crossover junction endodeoxyribonuclease RuvC

Gene

ruvC

Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction).UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi7MagnesiumUniRule annotation1
Metal bindingi68MagnesiumUniRule annotation1
Metal bindingi141MagnesiumUniRule annotation1
Metal bindingi144MagnesiumUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Nuclease
Biological processDNA damage, DNA recombination, DNA repair
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Crossover junction endodeoxyribonuclease RuvCUniRule annotation (EC:3.1.22.4UniRule annotation)
Alternative name(s):
Holliday junction nuclease RuvCUniRule annotation
Holliday junction resolvase RuvCUniRule annotation
Gene namesi
Name:ruvCUniRule annotation
Ordered Locus Names:Blon_1156, BLIJ_1183
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000001360 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001952371 – 194Crossover junction endodeoxyribonuclease RuvCAdd BLAST194

Proteomic databases

PRIDEiB7GR16

Structurei

3D structure databases

SMRiB7GR16
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the RuvC family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000012182
KOiK01159
OMAiGLTRCGI

Family and domain databases

Gene3Di3.30.420.10, 1 hit
HAMAPiMF_00034 RuvC, 1 hit
InterProiView protein in InterPro
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
IPR020563 X-over_junc_endoDNase_Mg_BS
IPR002176 X-over_junc_endoDNase_RuvC
PANTHERiPTHR30194 PTHR30194, 1 hit
PfamiView protein in Pfam
PF02075 RuvC, 1 hit
PRINTSiPR00696 RSOLVASERUVC
SUPFAMiSSF53098 SSF53098, 1 hit
TIGRFAMsiTIGR00228 ruvC, 1 hit
PROSITEiView protein in PROSITE
PS01321 RUVC, 1 hit

Sequencei

Sequence statusi: Complete.

B7GR16-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIILGVDPGL TRCGVGVIEA GEHRRLSFIH VDVVRSSPDI TQDLRLLAIY
60 70 80 90 100
NGLSEKMDRF APDAVSIERV FAQSNRNTVL GTAQAAGLAM LAAAQRGIPV
110 120 130 140 150
ALHTPTEAKL AITGNGQAQK VQVERMVTRV LNLTKMPTPA DAADALALAI
160 170 180 190
CHALRPAGAL QGGEREQHLT AAQRQWAEAA QNSTRRRKNS DRGM
Length:194
Mass (Da):20,819
Last modified:February 10, 2009 - v1
Checksum:iBFFCDDF50D290A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001095 Genomic DNA Translation: ACJ52246.1
AP010889 Genomic DNA Translation: BAJ68771.1
RefSeqiWP_012577503.1, NZ_JDTT01000068.1

Genome annotation databases

EnsemblBacteriaiACJ52246; ACJ52246; Blon_1156
BAJ68771; BAJ68771; BLIJ_1183
KEGGibln:Blon_1156
blon:BLIJ_1183
PATRICifig|391904.8.peg.1180

Similar proteinsi

Entry informationi

Entry nameiRUVC_BIFLS
AccessioniPrimary (citable) accession number: B7GR16
Secondary accession number(s): E8MJP4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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