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Protein

Undecaprenyl-diphosphatase

Gene

uppP

Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.UniRule annotation

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processAntibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBLON391904:G1H61-1165-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphataseUniRule annotation (EC:3.6.1.27UniRule annotation)
Alternative name(s):
Bacitracin resistance proteinUniRule annotation
Undecaprenyl pyrophosphate phosphataseUniRule annotation
Gene namesi
Name:uppPUniRule annotation
Ordered Locus Names:Blon_1151, BLIJ_1178
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000001360 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalUniRule annotationAdd BLAST21
Transmembranei93 – 113HelicalUniRule annotationAdd BLAST21
Transmembranei123 – 143HelicalUniRule annotationAdd BLAST21
Transmembranei198 – 218HelicalUniRule annotationAdd BLAST21
Transmembranei232 – 252HelicalUniRule annotationAdd BLAST21
Transmembranei268 – 288HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001488021 – 294Undecaprenyl-diphosphataseAdd BLAST294

Proteomic databases

PRIDEiB7GR11

Structurei

3D structure databases

SMRiB7GR11
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

HOGENOMiHOG000218357
KOiK06153
OMAiPDARMGW

Family and domain databases

HAMAPiMF_01006 Undec_diphosphatase, 1 hit
InterProiView protein in InterPro
IPR003824 UppP
PANTHERiPTHR30622 PTHR30622, 1 hit
PfamiView protein in Pfam
PF02673 BacA, 1 hit
TIGRFAMsiTIGR00753 undec_PP_bacA, 1 hit

Sequencei

Sequence statusi: Complete.

B7GR11-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFFQAIILG IVQALTEYLP VSSSAHIRIF GDLMLGSDPG AAFTAIIQIG
60 70 80 90 100
TELAVILYFR HDIINILTHW FGCLFGRNGK DWKARMGRGD EYATLGWNII
110 120 130 140 150
VGSIPIVILG FTLQDVIETS LRNLWITVTV LLVFGVLLWV VDAKARQNKT
160 170 180 190 200
MDDMTYRDAF LFGLGQSMAL IPGVSRSGGT ITVGRALGYT REAAVRLSFL
210 220 230 240 250
MAIPAVFGSG LLETVKAVKN YKTDAMFPGW GPTLVAMVIS FVLGYIVIIG
260 270 280 290
FLKFVSTFSY KAFAIYRIGL AVVVALLLIV GVLPAIDPSV AAAA
Length:294
Mass (Da):31,907
Last modified:February 10, 2009 - v1
Checksum:iD71C0063DDF3B820
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001095 Genomic DNA Translation: ACJ52241.1
AP010889 Genomic DNA Translation: BAJ68766.1
RefSeqiWP_012577499.1, NZ_JDTT01000050.1

Genome annotation databases

EnsemblBacteriaiACJ52241; ACJ52241; Blon_1151
BAJ68766; BAJ68766; BLIJ_1178
KEGGibln:Blon_1151
blon:BLIJ_1178
PATRICifig|391904.8.peg.1175

Similar proteinsi

Entry informationi

Entry nameiUPPP_BIFLS
AccessioniPrimary (citable) accession number: B7GR11
Secondary accession number(s): E8MJN9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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