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B7GQU7

- PGK_BIFLS

UniProt

B7GQU7 - PGK_BIFLS

Protein

Phosphoglycerate kinase

Gene

pgk

Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei35 – 351SubstrateUniRule annotation
    Binding sitei117 – 1171SubstrateUniRule annotation
    Binding sitei154 – 1541SubstrateUniRule annotation
    Binding sitei204 – 2041ATPUniRule annotation
    Binding sitei298 – 2981ATP; via carbonyl oxygenUniRule annotation
    Binding sitei329 – 3291ATPUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi358 – 3614ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. phosphoglycerate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON391904:GCDR-1118-MONOMER.
    UniPathwayiUPA00109; UER00185.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoglycerate kinaseUniRule annotation (EC:2.7.2.3UniRule annotation)
    Gene namesi
    Name:pgkUniRule annotation
    Ordered Locus Names:Blon_1087, BLIJ_1111
    OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
    Taxonomic identifieri391904 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000001360: Chromosome, UP000007256: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 401401Phosphoglycerate kinasePRO_1000192802Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi391904.Blon_1087.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni20 – 223Substrate bindingUniRule annotation
    Regioni58 – 614Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphoglycerate kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0126.
    HOGENOMiHOG000227108.
    KOiK00927.
    OrthoDBiEOG64N9Z0.

    Family and domain databases

    Gene3Di3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPiMF_00145. Phosphoglyc_kinase.
    InterProiIPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view]
    PANTHERiPTHR11406. PTHR11406. 1 hit.
    PfamiPF00162. PGK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000724. Pgk. 1 hit.
    PRINTSiPR00477. PHGLYCKINASE.
    SUPFAMiSSF53748. SSF53748. 1 hit.
    PROSITEiPS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7GQU7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKTLKDLGDL KGKRVLVRAD FNVPLDGTTI TDDGRIKAAL PTIKTLREEG    50
    AKVILMAHLG RPKGKVVPEL SLAPVAARLG ELLGTNVPLA KDTYGEDAQA 100
    KVAAMNDGDV VLLENVRFNP EETSKDADER AAYAKKIAAL GEAFVSDGFG 150
    VVHRAQGSNY DVAADLPAAA GLLVEKEVKA LSKATENPER PFTVVLGGSK 200
    VSDKLGVIEN LLDKANRLVI GGGMVFTFLK AKGYEVGTSL LEEDQLEKVK 250
    GYIETAEKNG VELVLPTDVV VNAGFPAGDT PVAPEVVAAD AIPADKMGLD 300
    IGPESQKLFH DKIVDSKTVV WNGPMGVFEV PEFAAGTKAV AQGLVDATAA 350
    GAFTIVGGGD SASAVRNLGF PEDGFSHIST GGGASLEFLE GKELPGLKVL 400
    E 401
    Length:401
    Mass (Da):41,896
    Last modified:February 10, 2009 - v1
    Checksum:iE1000743D5E0C47A
    GO

    Sequence cautioni

    The sequence BAJ68699.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001095 Genomic DNA. Translation: ACJ52177.1.
    AP010889 Genomic DNA. Translation: BAJ68699.1. Different initiation.
    RefSeqiYP_002322555.1. NC_011593.1.
    YP_005584869.1. NC_017219.1.

    Genome annotation databases

    EnsemblBacteriaiACJ52177; ACJ52177; Blon_1087.
    BAJ68699; BAJ68699; BLIJ_1111.
    GeneIDi12168032.
    7054705.
    KEGGibln:Blon_1087.
    blon:BLIJ_1111.
    PATRICi21123128. VBIBifLon71229_1082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001095 Genomic DNA. Translation: ACJ52177.1 .
    AP010889 Genomic DNA. Translation: BAJ68699.1 . Different initiation.
    RefSeqi YP_002322555.1. NC_011593.1.
    YP_005584869.1. NC_017219.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391904.Blon_1087.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ52177 ; ACJ52177 ; Blon_1087 .
    BAJ68699 ; BAJ68699 ; BLIJ_1111 .
    GeneIDi 12168032.
    7054705.
    KEGGi bln:Blon_1087.
    blon:BLIJ_1111.
    PATRICi 21123128. VBIBifLon71229_1082.

    Phylogenomic databases

    eggNOGi COG0126.
    HOGENOMi HOG000227108.
    KOi K00927.
    OrthoDBi EOG64N9Z0.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00185 .
    BioCyci BLON391904:GCDR-1118-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.1260. 1 hit.
    3.40.50.1270. 1 hit.
    HAMAPi MF_00145. Phosphoglyc_kinase.
    InterProi IPR001576. Phosphoglycerate_kinase.
    IPR015901. Phosphoglycerate_kinase_C.
    IPR015911. Phosphoglycerate_kinase_CS.
    IPR015824. Phosphoglycerate_kinase_N.
    [Graphical view ]
    PANTHERi PTHR11406. PTHR11406. 1 hit.
    Pfami PF00162. PGK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000724. Pgk. 1 hit.
    PRINTSi PR00477. PHGLYCKINASE.
    SUPFAMi SSF53748. SSF53748. 1 hit.
    PROSITEi PS00111. PGLYCERATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
      Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
      Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.

    Entry informationi

    Entry nameiPGK_BIFLS
    AccessioniPrimary (citable) accession number: B7GQU7
    Secondary accession number(s): E8MJH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3