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Protein

UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase

Gene

murG

Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).UniRule annotation

Catalytic activityi

UDP-N-acetylglucosamine + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = UDP + GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciBLON391904:G1H61-873-MONOMER
UniPathwayiUPA00219

Protein family/group databases

CAZyiGT28 Glycosyltransferase Family 28

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseUniRule annotation (EC:2.4.1.227UniRule annotation)
Alternative name(s):
Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferaseUniRule annotation
Gene namesi
Name:murGUniRule annotation
Ordered Locus Names:Blon_0856, BLIJ_0873
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaBifidobacterialesBifidobacteriaceaeBifidobacterium
Proteomesi
  • UP000001360 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001170021 – 393UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferaseAdd BLAST393

Proteomic databases

PRIDEiB7GQ78

Structurei

3D structure databases

ProteinModelPortaliB7GQ78
SMRiB7GQ78
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 28 family. MurG subfamily.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218323
KOiK02563
OMAiHQTKNAM

Family and domain databases

CDDicd03785 GT1_MurG, 1 hit
HAMAPiMF_00033 MurG, 1 hit
InterProiView protein in InterPro
IPR006009 GlcNAc_MurG
IPR007235 Glyco_trans_28_C
IPR004276 GlycoTrans_28_N
PfamiView protein in Pfam
PF04101 Glyco_tran_28_C, 1 hit
PF03033 Glyco_transf_28, 1 hit

Sequencei

Sequence statusi: Complete.

B7GQ78-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDQGTPHIVL AGGGTAGHVN PLLAVAGAIR DIEPTAQVTV IGTAVGLEKD
60 70 80 90 100
LVPEAGYELD TIEKVPFPRR PDLYMLRFPA KWKRETAKVR SILETRHADV
110 120 130 140 150
VAGFGGYASA PVYATAHKMG IPIAIHEQNA RAGMANKLGA RWADFIGTVY
160 170 180 190 200
EGTGLKPRAG ADVERVGLPL RPAIASLTKR IGDDRAAVRR ESAAQLGVDP
210 220 230 240 250
NRPLVLVTGG SLGAQSLNRA IASSAADLLA HAQIIHLTGR GKISEVRELV
260 270 280 290 300
TASAGADVLT GIGPESAGQG DYHTAEYLER IDMAFACADL VICRAGAGSV
310 320 330 340 350
SELAALGLPA IYVPLPIGNG EQRFNAEPVV NAGGGLLVAD KDLTPQWVHE
360 370 380 390
HVPDLLADHE RLAEFGRKAW EYGIRNAAEI MARHVLQLAE PSK
Length:393
Mass (Da):41,531
Last modified:February 10, 2009 - v1
Checksum:i13A1B49123AB2F14
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001095 Genomic DNA Translation: ACJ51958.1
AP010889 Genomic DNA Translation: BAJ68465.1
RefSeqiWP_012577231.1, NZ_JDTT01000021.1

Genome annotation databases

EnsemblBacteriaiACJ51958; ACJ51958; Blon_0856
BAJ68465; BAJ68465; BLIJ_0873
KEGGibln:Blon_0856
blon:BLIJ_0873
PATRICifig|391904.8.peg.880

Similar proteinsi

Entry informationi

Entry nameiMURG_BIFLS
AccessioniPrimary (citable) accession number: B7GQ78
Secondary accession number(s): E8MR40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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