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B7GQ51

- HIS4_BIFLS

UniProt

B7GQ51 - HIS4_BIFLS

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Protein

1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase

Gene

hisA

Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei10 – 101Proton acceptorUniRule annotation
Active sitei131 – 1311Proton donorUniRule annotation

GO - Molecular functioni

  1. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity Source: UniProtKB-HAMAP
  2. phosphoribosylanthranilate isomerase activity Source: InterPro

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
  2. tryptophan biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Enzyme and pathway databases

BioCyciBLON391904:GCDR-853-MONOMER.
UniPathwayiUPA00031; UER00009.

Names & Taxonomyi

Protein namesi
Recommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomeraseUniRule annotation (EC:5.3.1.16UniRule annotation)
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomeraseUniRule annotation
Gene namesi
Name:hisAUniRule annotation
Ordered Locus Names:Blon_0828, BLIJ_0844
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000001360: Chromosome, UP000007256: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2412411-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerasePRO_1000148954Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391904.Blon_0828.

Structurei

3D structure databases

ProteinModelPortaliB7GQ51.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HisA/HisF family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0106.
HOGENOMiHOG000224614.
KOiK01814.
K01817.
OMAiQRDYGSD.
OrthoDBiEOG6H1Q3W.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01014. HisA.
InterProiIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01919. hisA-trpF. 1 hit.

Sequencei

Sequence statusi: Complete.

B7GQ51-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLTLLPAVD VRDGKAVRLR QGESGSETDY GSPFEAARTW VEAGAEWIHL
60 70 80 90 100
VDLDAAFGTG NNRDQLREIV HELGDRVNIE LSGGVRDDAS LDAALEAGAA
110 120 130 140 150
RVNIGTAALE NPDWTASVIK KYGDRVAVGL DVRGHTLAAR GWTREGGDLF
160 170 180 190 200
ETMKFLDSVG CSRYVVTDVA KDGMMSGPNI QLLREVAERT DAKVTASGGI
210 220 230 240
SKLDDLRAIK ELAEIGVDSA ILGKSLYARA FTLQEALAVA K
Length:241
Mass (Da):25,758
Last modified:February 10, 2009 - v1
Checksum:i96D43955E75B5B18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ51931.1.
AP010889 Genomic DNA. Translation: BAJ68436.1.
RefSeqiWP_012577204.1. NC_017219.1.
YP_002322309.1. NC_011593.1.
YP_005584606.1. NC_017219.1.

Genome annotation databases

EnsemblBacteriaiACJ51931; ACJ51931; Blon_0828.
BAJ68436; BAJ68436; BLIJ_0844.
GeneIDi12166421.
7054859.
KEGGibln:Blon_0828.
blon:BLIJ_0844.
PATRICi21122612. VBIBifLon71229_0828.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ51931.1 .
AP010889 Genomic DNA. Translation: BAJ68436.1 .
RefSeqi WP_012577204.1. NC_017219.1.
YP_002322309.1. NC_011593.1.
YP_005584606.1. NC_017219.1.

3D structure databases

ProteinModelPortali B7GQ51.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391904.Blon_0828.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ51931 ; ACJ51931 ; Blon_0828 .
BAJ68436 ; BAJ68436 ; BLIJ_0844 .
GeneIDi 12166421.
7054859.
KEGGi bln:Blon_0828.
blon:BLIJ_0844.
PATRICi 21122612. VBIBifLon71229_0828.

Phylogenomic databases

eggNOGi COG0106.
HOGENOMi HOG000224614.
KOi K01814.
K01817.
OMAi QRDYGSD.
OrthoDBi EOG6H1Q3W.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00009 .
BioCyci BLON391904:GCDR-853-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01014. HisA.
InterProi IPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR010188. HisA_TrpF.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00977. His_biosynth. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01919. hisA-trpF. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
    Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.

Entry informationi

Entry nameiHIS4_BIFLS
AccessioniPrimary (citable) accession number: B7GQ51
Secondary accession number(s): E8MR11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3