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B7GQ20

- THIM_BIFLS

UniProt

B7GQ20 - THIM_BIFLS

Protein

Hydroxyethylthiazole kinase

Gene

thiM

Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ).UniRule annotation

    Catalytic activityi

    ATP + 4-methyl-5-(2-hydroxyethyl)thiazole = ADP + 4-methyl-5-(2-phosphonooxyethyl)thiazole.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei70 – 701Substrate; via amide nitrogenUniRule annotation
    Binding sitei145 – 1451ATPUniRule annotation
    Binding sitei217 – 2171ATPUniRule annotation
    Binding sitei244 – 2441Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. hydroxyethylthiazole kinase activity Source: UniProtKB-HAMAP
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. thiamine biosynthetic process Source: UniProtKB-KW
    2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Thiamine biosynthesis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON391904:GCDR-819-MONOMER.
    UniPathwayiUPA00060; UER00139.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hydroxyethylthiazole kinaseUniRule annotation (EC:2.7.1.50UniRule annotation)
    Alternative name(s):
    4-methyl-5-beta-hydroxyethylthiazole kinaseUniRule annotation
    Short name:
    TH kinaseUniRule annotation
    Short name:
    Thz kinaseUniRule annotation
    Gene namesi
    Name:thiMUniRule annotation
    Ordered Locus Names:Blon_0797, BLIJ_0811
    OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
    Taxonomic identifieri391904 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000001360: Chromosome, UP000007256: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 314314Hydroxyethylthiazole kinasePRO_0000383825Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi391904.Blon_0797.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Thz kinase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2145.
    HOGENOMiHOG000114352.
    KOiK00878.
    OMAiQTFTANV.
    OrthoDBiEOG628F8M.

    Family and domain databases

    Gene3Di3.40.1190.20. 1 hit.
    HAMAPiMF_00228. Thz_kinase.
    InterProiIPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view]
    PfamiPF02110. HK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000513. Thz_kinase. 1 hit.
    PRINTSiPR01099. HYETHTZKNASE.
    SUPFAMiSSF53613. SSF53613. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B7GQ20-1 [UniParc]FASTAAdd to Basket

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    MSNSASSFAD VSSGCTAGTP VPADSPIRDN IADAVRRVRE TTPLAQSFTN    50
    FVTINLVANA QLAAGGTAAM SFLPDDVIET AKIAGANYIN VGTLLPFYKD 100
    ALPEIAQRLN YLDKPWVLDP VAAGIGHTRT AILQTFKAAP PTMIRANASE 150
    VIALANMWGL NTETVGDASE HRPAGVESVD DVESATGAAV ALAQYLTEQH 200
    AKHSSHDAST RCAVAVSGIA DLVTDGETVY RLPGGSAMMT KITGAGCSLG 250
    GVAATYLAVS DPLTAALSAS LLYNRAAEIA DTTSHGPGSF QVAFLDALWN 300
    VTAEQVAESE ILVQ 314
    Length:314
    Mass (Da):32,492
    Last modified:February 10, 2009 - v1
    Checksum:i644F22DBCBC50A1D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001095 Genomic DNA. Translation: ACJ51900.1.
    AP010889 Genomic DNA. Translation: BAJ68403.1.
    RefSeqiYP_002322278.1. NC_011593.1.
    YP_005584573.1. NC_017219.1.

    Genome annotation databases

    EnsemblBacteriaiACJ51900; ACJ51900; Blon_0797.
    BAJ68403; BAJ68403; BLIJ_0811.
    GeneIDi12166385.
    7054828.
    KEGGibln:Blon_0797.
    blon:BLIJ_0811.
    PATRICi21122540. VBIBifLon71229_0795.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001095 Genomic DNA. Translation: ACJ51900.1 .
    AP010889 Genomic DNA. Translation: BAJ68403.1 .
    RefSeqi YP_002322278.1. NC_011593.1.
    YP_005584573.1. NC_017219.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391904.Blon_0797.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ51900 ; ACJ51900 ; Blon_0797 .
    BAJ68403 ; BAJ68403 ; BLIJ_0811 .
    GeneIDi 12166385.
    7054828.
    KEGGi bln:Blon_0797.
    blon:BLIJ_0811.
    PATRICi 21122540. VBIBifLon71229_0795.

    Phylogenomic databases

    eggNOGi COG2145.
    HOGENOMi HOG000114352.
    KOi K00878.
    OMAi QTFTANV.
    OrthoDBi EOG628F8M.

    Enzyme and pathway databases

    UniPathwayi UPA00060 ; UER00139 .
    BioCyci BLON391904:GCDR-819-MONOMER.

    Family and domain databases

    Gene3Di 3.40.1190.20. 1 hit.
    HAMAPi MF_00228. Thz_kinase.
    InterProi IPR000417. Hyethyz_kinase.
    IPR029056. Ribokinase-like.
    [Graphical view ]
    Pfami PF02110. HK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000513. Thz_kinase. 1 hit.
    PRINTSi PR01099. HYETHTZKNASE.
    SUPFAMi SSF53613. SSF53613. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
      Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
      Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.

    Entry informationi

    Entry nameiTHIM_BIFLS
    AccessioniPrimary (citable) accession number: B7GQ20
    Secondary accession number(s): E8MQX8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3