ID   B7GPM3_BIFLS            Unreviewed;       760 AA.
AC   B7GPM3;
DT   10-FEB-2009, integrated into UniProtKB/TrEMBL.
DT   10-FEB-2009, sequence version 1.
DT   24-JAN-2024, entry version 80.
DE   RecName: Full=exo-alpha-sialidase {ECO:0000256|ARBA:ARBA00012733};
DE            EC=3.2.1.18 {ECO:0000256|ARBA:ARBA00012733};
GN   OrderedLocusNames=Blon_0646 {ECO:0000313|EMBL:ACJ51753.1};
OS   Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM
OS   1222 / NCTC 11817 / S12).
OC   Bacteria; Actinomycetota; Actinomycetes; Bifidobacteriales;
OC   Bifidobacteriaceae; Bifidobacterium.
OX   NCBI_TaxID=391904 {ECO:0000313|EMBL:ACJ51753.1, ECO:0000313|Proteomes:UP000001360};
RN   [1] {ECO:0000313|EMBL:ACJ51753.1, ECO:0000313|Proteomes:UP000001360}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12 [JGI]
RC   {ECO:0000313|Proteomes:UP000001360};
RX   PubMed=19033196; DOI=10.1073/pnas.0809584105;
RA   Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R.,
RA   Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P.,
RA   Richardson P.M., Mills D.A.;
RT   "The genome sequence of Bifidobacterium longum subsp. infantis reveals
RT   adaptations for milk utilization within the infant microbiome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008).
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 33 family.
CC       {ECO:0000256|ARBA:ARBA00009348}.
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DR   EMBL; CP001095; ACJ51753.1; -; Genomic_DNA.
DR   RefSeq; WP_012577044.1; NZ_JDTT01000040.1.
DR   AlphaFoldDB; B7GPM3; -.
DR   SMR; B7GPM3; -.
DR   CAZy; GH33; Glycoside Hydrolase Family 33.
DR   KEGG; bln:Blon_0646; -.
DR   Proteomes; UP000001360; Chromosome.
DR   GO; GO:0004308; F:exo-alpha-sialidase activity; IEA:InterPro.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.120.10.10; -; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR001791; Laminin_G.
DR   InterPro; IPR011040; Sialidase.
DR   InterPro; IPR026856; Sialidase_fam.
DR   InterPro; IPR036278; Sialidase_sf.
DR   InterPro; IPR023364; Trans_sialidase_dom3.
DR   PANTHER; PTHR10628; SIALIDASE; 1.
DR   PANTHER; PTHR10628:SF25; SIALIDASE-1; 1.
DR   Pfam; PF13088; BNR_2; 1.
DR   Pfam; PF02210; Laminin_G_2; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 2.
DR   SUPFAM; SSF50939; Sialidases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000313|EMBL:ACJ51753.1};
KW   Signal {ECO:0000256|ARBA:ARBA00022729}.
FT   DOMAIN          194..272
FT                   /note="Laminin G"
FT                   /evidence="ECO:0000259|Pfam:PF02210"
FT   DOMAIN          507..733
FT                   /note="Sialidase"
FT                   /evidence="ECO:0000259|Pfam:PF13088"
SQ   SEQUENCE   760 AA;  82562 MW;  605F0A1CC4806313 CRC64;
     MAASNPISWS QRTFPSPEGT IACRFRAHAD GRIFDAVNGS ANDAPLLICA IEHDALRVRA
     TTPRQHVDFD IEDTTGIADG AMHTFALTFG EFGTRVYLDG SQCFSGTANL CPTTLTGTEG
     SGQGAIRLAG PSIDVTDMRL HAIPLTSESI AALTPRPAPD IDFAAAQLAP RDVRRVRTLR
     SGTIFMHFRV RGPRQYGTLL AAGERGEERL AVSIDDNGIT MTAADGLYEP STYHARGAWD
     DGRWHDLSIR SARGAIDMYV DGWHELHQAG QVFFGDWPQL DEVAIGQNTE GVRLMGEVRN
     GGVFTTPLTD GAIRRLSDAP ALTTTALFDK GYHGSVSYRI PSIIRTPHGV VVAGADQRTA
     IANDAPNHIN FVMRRSLDGG RTWLDMQTVI ANPGEGVDGA CTIDSCLVCD ERNGRLTVLI
     DRFAGGVGLP NNTPGTGVDR HGRPCLYDRA GTRYVLADDG TVLDGGGERT GYRVDAHGNV
     THEGRASGNI YLKEGADPDE SLLIERTSFI IELHSDDDGE TWSTPRNINH MIKEDWMHFL
     GVSPGNGIQL QASEHRGRLL VPFYCTGASL KHYSGGALIS DDGGDTWRRG SMINDGRIVN
     GTAVDPKNIR DDDATTHESV FVERADGTVV CFFRNQNHAG RIGVALSHDG GETWDDLYFD
     KDVPDIFCQP NAVACAPRSD TMVFANASQM LPYRGNGVLR LSLDGARTWA AHRCINPYHY
     GYQCMTMLPD GELGLLWERE TAGLYFTTLP LSVFGAAETH
//