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B7GNH2

- PNP_BIFLS

UniProt

B7GNH2 - PNP_BIFLS

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Protein

Polyribonucleotide nucleotidyltransferase

Gene
pnp, Blon_2270, BLIJ_2342
Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction By similarity.UniRule annotation

Catalytic activityi

RNA(n+1) + phosphate = RNA(n) + a nucleoside diphosphate.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi521 – 5211Magnesium By similarity
Metal bindingi527 – 5271Magnesium By similarity

GO - Molecular functioni

  1. 3'-5'-exoribonuclease activity Source: InterPro
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. polyribonucleotide nucleotidyltransferase activity Source: UniProtKB-HAMAP
  4. RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. mRNA catabolic process Source: UniProtKB-HAMAP
  2. RNA processing Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Ligandi

Magnesium, Metal-binding, RNA-binding

Enzyme and pathway databases

BioCyciBLON391904:GCDR-2347-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Polyribonucleotide nucleotidyltransferase (EC:2.7.7.8)
Alternative name(s):
Polynucleotide phosphorylase
Short name:
PNPase
Gene namesi
Name:pnp
Ordered Locus Names:Blon_2270, BLIJ_2342
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000001360: Chromosome, UP000007256: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 914914Polyribonucleotide nucleotidyltransferaseUniRule annotationPRO_0000381867Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi391904.Blon_2270.

Structurei

3D structure databases

ProteinModelPortaliB7GNH2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini587 – 64660KHAdd
BLAST
Domaini658 – 73073S1 motifAdd
BLAST

Sequence similaritiesi

Contains 1 KH domain.
Contains 1 S1 motif domain.

Phylogenomic databases

eggNOGiCOG1185.
HOGENOMiHOG000218326.
KOiK00962.
OMAiPRWDWVA.
OrthoDBiEOG6WT8CC.

Family and domain databases

Gene3Di1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPiMF_01595. PNPase.
InterProiIPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view]
PANTHERiPTHR11252. PTHR11252. 1 hit.
PfamiPF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsiTIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEiPS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B7GNH2-1 [UniParc]FASTAAdd to Basket

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MEGPEIKAVE AVIDNGSFGK RTLRFETGRL AQQADGAVAA YLDDDSMILS    50
TTTAGSSPKE NYDFFPLTVD VEEKMYAAGK IPGSFFRREG RPSSEAILAC 100
RIIDRPLRPL FPHTLRNEVQ VVETVLAVNP DDAYDVIALN AASASTMISG 150
LPFEGPVSGV RLALIDGQWV AFPRWSERER AVFEIVVAGR VVENGDVAIA 200
MIEAGAGKNA WHLIYDEGQT KPDEEVVAGG LEAAKPFIKV ICEAQDELKK 250
IAAKETKEFQ LFPEYTDELY ARIDEIAHKD LDEALSIAEK LPRQDRIHEI 300
KEHVREVLAD EFTDMDDAEK DKELGNAFKE LQRQIVRRRI LTEDYRIDGR 350
GLRDIRTLSA EVDIVPRVHG SALFQRGETQ ILGVTTLNML KMEQQIDALS 400
GPQSKRYMHN YEMPPYSTGE TGRVGSPKRR EIGHGALAEK ALVPVLPSRE 450
EFPYAIRQVS EAIGSNGSTS MGSVCASTLS LLAAGVPLKA PVAGIAMGLV 500
SGDVDGQHIF KTLTDILGAE DAFGDMDFKV AGTSEFITAL QLDTKLDGIP 550
ADILAAALQQ AKEARATILE VINECIDGPA EMSEFAPRII TTSVPVEKIG 600
EVIGPKGKMI NQIQEDTGAE IAIEDDGTVF ISSEGGEAAK KAKSIIDSIA 650
NPHVPEAGET YNGKVVKTTS FGAFVNLTPG TDGLLHISQI RNLANGERID 700
AVEDVLREGD TVEVIVQGVD DRGKISLAIP GFEDQENNAR PSRGDRDDRR 750
GGRGRGDRDD RRGGRGRRSD RDDRDFDDRD DRPRRRRSDD FEDDYDDRPR 800
RRRSDDRDFD RDDRDDDRPR RRRSADRDFD DRDDRDARDS RDDDRPRRRR 850
SADRDDRGDR DDRRGGFRGG RGRGSDRNPR YATDDNYDDY RADREERTER 900
PRRRVRRDFD PFED 914
Length:914
Mass (Da):101,922
Last modified:February 10, 2009 - v1
Checksum:i24F9B6F629FCA9E1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ53328.1.
AP010889 Genomic DNA. Translation: BAJ69919.1.
RefSeqiYP_002323706.1. NC_011593.1.
YP_005586089.1. NC_017219.1.

Genome annotation databases

EnsemblBacteriaiACJ53328; ACJ53328; Blon_2270.
BAJ69919; BAJ69919; BLIJ_2342.
GeneIDi12168002.
7053591.
KEGGibln:Blon_2270.
blon:BLIJ_2342.
PATRICi21125619. VBIBifLon71229_2280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ53328.1 .
AP010889 Genomic DNA. Translation: BAJ69919.1 .
RefSeqi YP_002323706.1. NC_011593.1.
YP_005586089.1. NC_017219.1.

3D structure databases

ProteinModelPortali B7GNH2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391904.Blon_2270.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ53328 ; ACJ53328 ; Blon_2270 .
BAJ69919 ; BAJ69919 ; BLIJ_2342 .
GeneIDi 12168002.
7053591.
KEGGi bln:Blon_2270.
blon:BLIJ_2342.
PATRICi 21125619. VBIBifLon71229_2280.

Phylogenomic databases

eggNOGi COG1185.
HOGENOMi HOG000218326.
KOi K00962.
OMAi PRWDWVA.
OrthoDBi EOG6WT8CC.

Enzyme and pathway databases

BioCyci BLON391904:GCDR-2347-MONOMER.

Family and domain databases

Gene3Di 1.10.10.400. 1 hit.
2.40.50.140. 1 hit.
3.30.1370.10. 1 hit.
3.30.230.70. 2 hits.
HAMAPi MF_01595. PNPase.
InterProi IPR001247. ExoRNase_PH_dom1.
IPR015847. ExoRNase_PH_dom2.
IPR004087. KH_dom.
IPR004088. KH_dom_type_1.
IPR012340. NA-bd_OB-fold.
IPR012162. PNPase.
IPR027408. PNPase/RNase_PH_dom.
IPR015848. PNPase_PH_RNA-bd_bac/org-type.
IPR014069. pppGpp_PNP.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR022967. RNA-binding_domain_S1.
[Graphical view ]
PANTHERi PTHR11252. PTHR11252. 1 hit.
Pfami PF00013. KH_1. 1 hit.
PF03726. PNPase. 1 hit.
PF01138. RNase_PH. 2 hits.
PF03725. RNase_PH_C. 1 hit.
PF00575. S1. 1 hit.
[Graphical view ]
SMARTi SM00322. KH. 1 hit.
SM00316. S1. 1 hit.
[Graphical view ]
SUPFAMi SSF46915. SSF46915. 1 hit.
SSF50249. SSF50249. 1 hit.
SSF54211. SSF54211. 2 hits.
SSF54791. SSF54791. 1 hit.
SSF55666. SSF55666. 2 hits.
TIGRFAMsi TIGR03591. polynuc_phos. 1 hit.
TIGR02696. pppGpp_PNP. 1 hit.
PROSITEi PS50084. KH_TYPE_1. 1 hit.
PS50126. S1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
    Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.

Entry informationi

Entry nameiPNP_BIFLS
AccessioniPrimary (citable) accession number: B7GNH2
Secondary accession number(s): E8MNQ3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 1, 2009
Last sequence update: February 10, 2009
Last modified: May 14, 2014
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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