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B7GN27

- NTPA_BIFLS

UniProt

B7GN27 - NTPA_BIFLS

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Protein

Non-canonical purine NTP pyrophosphatase

Gene
Blon_0412, BLIJ_0420
Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions By similarity.UniRule annotation

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

Cofactori

Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi74 – 741Magnesium or manganese By similarity
Binding sitei196 – 1961Substrate By similarity
Binding sitei230 – 2301Substrate By similarity
Binding sitei236 – 2361Substrate By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. nucleoside-triphosphatase activity Source: InterPro
  3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
  4. nucleotide binding Source: UniProtKB-KW

GO - Biological processi

  1. nucleoside triphosphate catabolic process Source: InterPro
  2. purine nucleotide metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciBLON391904:GCDR-425-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP pyrophosphatase (EC:3.6.1.19)
Alternative name(s):
Non-standard purine NTP pyrophosphatase
Nucleoside-triphosphate diphosphatase
Nucleoside-triphosphate pyrophosphatase
Short name:
NTPase
Gene namesi
Ordered Locus Names:Blon_0412, BLIJ_0420
OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Taxonomic identifieri391904 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000001360: Chromosome, UP000007256: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 252252Non-canonical purine NTP pyrophosphataseUniRule annotationPRO_1000184578Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi391904.Blon_0412.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 126Substrate binding By similarity
Regioni74 – 752Substrate binding By similarity

Sequence similaritiesi

Belongs to the HAM1 NTPase family.

Phylogenomic databases

eggNOGiCOG0127.
HOGENOMiHOG000293319.
KOiK02428.
OMAiEAIIATH.
OrthoDBiEOG6CZQQP.

Family and domain databases

Gene3Di3.90.950.10. 2 hits.
HAMAPiMF_01405. Non_canon_purine_NTPase.
InterProiIPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view]
PANTHERiPTHR11067. PTHR11067. 1 hit.
PfamiPF01725. Ham1p_like. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 2 hits.

Sequencei

Sequence statusi: Complete.

B7GN27-1 [UniParc]FASTAAdd to Basket

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MQIVVATHNE GKLVEIRRIL EEDLGVDAEN IELVSAGSLH LPDPVETGVT    50
FQENALLKAR AVAIRTGLPA VADDSGLIVD VMGNAPGILS ARWAGAHGHD 100
KANNALLLAQ IGDIPDDKRT ARFRCAAALV VPDTEAGADV TGGVAADGIT 150
VHTTAADGST APVHARYAIK SETVELGDMP GRIIREARGE HGFGYDPLFV 200
PDDQPAGRVS TEPDHEGEPL TSAEMTSAEK NAISHRGKAL KALVPAIEAL 250
LH 252
Length:252
Mass (Da):26,368
Last modified:February 10, 2009 - v1
Checksum:i0C3290BF5D6A6DD4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ51533.1.
AP010889 Genomic DNA. Translation: BAJ68014.1.
RefSeqiWP_012576833.1. NC_017219.1.
YP_002321911.1. NC_011593.1.
YP_005584184.1. NC_017219.1.

Genome annotation databases

EnsemblBacteriaiACJ51533; ACJ51533; Blon_0412.
BAJ68014; BAJ68014; BLIJ_0420.
GeneIDi12167331.
7053505.
KEGGibln:Blon_0412.
blon:BLIJ_0420.
PATRICi21121758. VBIBifLon71229_0413.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001095 Genomic DNA. Translation: ACJ51533.1 .
AP010889 Genomic DNA. Translation: BAJ68014.1 .
RefSeqi WP_012576833.1. NC_017219.1.
YP_002321911.1. NC_011593.1.
YP_005584184.1. NC_017219.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 391904.Blon_0412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACJ51533 ; ACJ51533 ; Blon_0412 .
BAJ68014 ; BAJ68014 ; BLIJ_0420 .
GeneIDi 12167331.
7053505.
KEGGi bln:Blon_0412.
blon:BLIJ_0420.
PATRICi 21121758. VBIBifLon71229_0413.

Phylogenomic databases

eggNOGi COG0127.
HOGENOMi HOG000293319.
KOi K02428.
OMAi EAIIATH.
OrthoDBi EOG6CZQQP.

Enzyme and pathway databases

BioCyci BLON391904:GCDR-425-MONOMER.

Family and domain databases

Gene3Di 3.90.950.10. 2 hits.
HAMAPi MF_01405. Non_canon_purine_NTPase.
InterProi IPR002637. Ham1p-like.
IPR029001. ITPase-like_fam.
IPR020922. NTPase.
[Graphical view ]
PANTHERi PTHR11067. PTHR11067. 1 hit.
Pfami PF01725. Ham1p_like. 1 hit.
[Graphical view ]
SUPFAMi SSF52972. SSF52972. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
    Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.

Entry informationi

Entry nameiNTPA_BIFLS
AccessioniPrimary (citable) accession number: B7GN27
Secondary accession number(s): E8MPT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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