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B7GN27

- NTPA_BIFLS

UniProt

B7GN27 - NTPA_BIFLS

Protein

Non-canonical purine NTP pyrophosphatase

Gene

Blon_0412

Organism
Bifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP/dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions.UniRule annotation

    Catalytic activityi

    A nucleoside triphosphate + H2O = a nucleotide + diphosphate.UniRule annotation

    Cofactori

    Binds 1 divalent metal cation ion per subunit; can use either magnesium or manganese.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi74 – 741Magnesium or manganeseUniRule annotation
    Binding sitei196 – 1961SubstrateUniRule annotation
    Binding sitei230 – 2301SubstrateUniRule annotation
    Binding sitei236 – 2361SubstrateUniRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. nucleoside-triphosphatase activity Source: InterPro
    3. nucleoside-triphosphate diphosphatase activity Source: UniProtKB-HAMAP
    4. nucleotide binding Source: UniProtKB-KW

    GO - Biological processi

    1. nucleoside triphosphate catabolic process Source: InterPro
    2. purine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Nucleotide metabolism

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBLON391904:GCDR-425-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Non-canonical purine NTP pyrophosphataseUniRule annotation (EC:3.6.1.19UniRule annotation)
    Alternative name(s):
    Non-standard purine NTP pyrophosphataseUniRule annotation
    Nucleoside-triphosphate diphosphataseUniRule annotation
    Nucleoside-triphosphate pyrophosphataseUniRule annotation
    Short name:
    NTPaseUniRule annotation
    Gene namesi
    Ordered Locus Names:Blon_0412, BLIJ_0420
    OrganismiBifidobacterium longum subsp. infantis (strain ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12)
    Taxonomic identifieri391904 [NCBI]
    Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
    ProteomesiUP000001360: Chromosome, UP000007256: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252Non-canonical purine NTP pyrophosphatasePRO_1000184578Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi391904.Blon_0412.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 126Substrate bindingUniRule annotation
    Regioni74 – 752Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the HAM1 NTPase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0127.
    HOGENOMiHOG000293319.
    KOiK02428.
    OMAiEAIIATH.
    OrthoDBiEOG6CZQQP.

    Family and domain databases

    Gene3Di3.90.950.10. 2 hits.
    HAMAPiMF_01405. Non_canon_purine_NTPase.
    InterProiIPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view]
    PANTHERiPTHR11067. PTHR11067. 1 hit.
    PfamiPF01725. Ham1p_like. 1 hit.
    [Graphical view]
    SUPFAMiSSF52972. SSF52972. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    B7GN27-1 [UniParc]FASTAAdd to Basket

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    MQIVVATHNE GKLVEIRRIL EEDLGVDAEN IELVSAGSLH LPDPVETGVT    50
    FQENALLKAR AVAIRTGLPA VADDSGLIVD VMGNAPGILS ARWAGAHGHD 100
    KANNALLLAQ IGDIPDDKRT ARFRCAAALV VPDTEAGADV TGGVAADGIT 150
    VHTTAADGST APVHARYAIK SETVELGDMP GRIIREARGE HGFGYDPLFV 200
    PDDQPAGRVS TEPDHEGEPL TSAEMTSAEK NAISHRGKAL KALVPAIEAL 250
    LH 252
    Length:252
    Mass (Da):26,368
    Last modified:February 10, 2009 - v1
    Checksum:i0C3290BF5D6A6DD4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001095 Genomic DNA. Translation: ACJ51533.1.
    AP010889 Genomic DNA. Translation: BAJ68014.1.
    RefSeqiWP_012576833.1. NC_017219.1.
    YP_002321911.1. NC_011593.1.
    YP_005584184.1. NC_017219.1.

    Genome annotation databases

    EnsemblBacteriaiACJ51533; ACJ51533; Blon_0412.
    BAJ68014; BAJ68014; BLIJ_0420.
    GeneIDi12167331.
    7053505.
    KEGGibln:Blon_0412.
    blon:BLIJ_0420.
    PATRICi21121758. VBIBifLon71229_0413.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001095 Genomic DNA. Translation: ACJ51533.1 .
    AP010889 Genomic DNA. Translation: BAJ68014.1 .
    RefSeqi WP_012576833.1. NC_017219.1.
    YP_002321911.1. NC_011593.1.
    YP_005584184.1. NC_017219.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 391904.Blon_0412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ51533 ; ACJ51533 ; Blon_0412 .
    BAJ68014 ; BAJ68014 ; BLIJ_0420 .
    GeneIDi 12167331.
    7053505.
    KEGGi bln:Blon_0412.
    blon:BLIJ_0420.
    PATRICi 21121758. VBIBifLon71229_0413.

    Phylogenomic databases

    eggNOGi COG0127.
    HOGENOMi HOG000293319.
    KOi K02428.
    OMAi EAIIATH.
    OrthoDBi EOG6CZQQP.

    Enzyme and pathway databases

    BioCyci BLON391904:GCDR-425-MONOMER.

    Family and domain databases

    Gene3Di 3.90.950.10. 2 hits.
    HAMAPi MF_01405. Non_canon_purine_NTPase.
    InterProi IPR002637. Ham1p-like.
    IPR029001. ITPase-like_fam.
    IPR020922. NTPase.
    [Graphical view ]
    PANTHERi PTHR11067. PTHR11067. 1 hit.
    Pfami PF01725. Ham1p_like. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52972. SSF52972. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "The genome sequence of Bifidobacterium longum subsp. infantis reveals adaptations for milk utilization within the infant microbiome."
      Sela D.A., Chapman J., Adeuya A., Kim J.H., Chen F., Whitehead T.R., Lapidus A., Rokhsar D.S., Lebrilla C.B., German J.B., Price N.P., Richardson P.M., Mills D.A.
      Proc. Natl. Acad. Sci. U.S.A. 105:18964-18969(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 15697 / DSM 20088 / JCM 1222 / NCTC 11817 / S12.

    Entry informationi

    Entry nameiNTPA_BIFLS
    AccessioniPrimary (citable) accession number: B7GN27
    Secondary accession number(s): E8MPT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3