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B7GME7

- NUOH_ANOFW

UniProt

B7GME7 - NUOH_ANOFW

Protein

NADH-quinone oxidoreductase subunit H

Gene

nuoH

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone.UniRule annotation

    Catalytic activityi

    NADH + quinone = NAD+ + quinol.UniRule annotation

    GO - Molecular functioni

    1. NADH dehydrogenase (quinone) activity Source: UniProtKB-EC
    2. quinone binding Source: UniProtKB-KW

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD, Ubiquinone

    Enzyme and pathway databases

    BioCyciAFLA491915:GHEO-2785-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NADH-quinone oxidoreductase subunit HUniRule annotation (EC:1.6.99.5UniRule annotation)
    Alternative name(s):
    NADH dehydrogenase I subunit HUniRule annotation
    NDH-1 subunit HUniRule annotation
    Gene namesi
    Name:nuoHUniRule annotation
    Ordered Locus Names:Aflv_2696
    OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)
    Taxonomic identifieri491915 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
    ProteomesiUP000000742: Chromosome

    Subcellular locationi

    Cell membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 333333NADH-quinone oxidoreductase subunit HPRO_1000143570Add
    BLAST

    Keywords - PTMi

    Quinone

    Interactioni

    Subunit structurei

    NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.UniRule annotation

    Protein-protein interaction databases

    STRINGi491915.Aflv_2696.

    Structurei

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei17 – 3721HelicalUniRule annotationAdd
    BLAST
    Transmembranei88 – 10821HelicalUniRule annotationAdd
    BLAST
    Transmembranei117 – 13721HelicalUniRule annotationAdd
    BLAST
    Transmembranei159 – 17921HelicalUniRule annotationAdd
    BLAST
    Transmembranei191 – 21121HelicalUniRule annotationAdd
    BLAST
    Transmembranei241 – 26121HelicalUniRule annotationAdd
    BLAST
    Transmembranei273 – 29321HelicalUniRule annotationAdd
    BLAST
    Transmembranei313 – 33321HelicalUniRule annotationAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the complex I subunit 1 family.UniRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1005.
    HOGENOMiHOG000228276.
    KOiK00337.
    OMAiGAFRNFA.
    OrthoDBiEOG6B62B4.

    Family and domain databases

    HAMAPiMF_01350. NDH1_NuoH.
    InterProiIPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view]
    PANTHERiPTHR11432. PTHR11432. 1 hit.
    PfamiPF00146. NADHdh. 1 hit.
    [Graphical view]
    PROSITEiPS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B7GME7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMEQLLQSTP SWTNVAIFFA IGVGLLLVVL GFVTYGILAE RKVMGFMQGR    50
    IGPNQVGGRW GLLQTVADVL KLLLKEDTIP KAADRPLFIL APVIAFAPAF 100
    MVLAALPFTD ALQFADIGVG LLYYIAVSGL TTIGVVTGAW ASNNKYALLG 150
    GMRAAAQMIS YEVPLVMSVI GVILLSGSLN LNDIVAAQKD VWFIVVQPIG 200
    FLVFLIAAVA ELNRTPFDLP EAESELVAGF HVEYSGFRWA FFMLAEYVYF 250
    FAMAALTTVL FLGGWHPLPF LGFIPGAVWF ALKFSLVVFL FIWFRITFPR 300
    VRADQLMEFG WKVLLPVALV NIFVTALVKQ LFF 333
    Length:333
    Mass (Da):36,664
    Last modified:February 10, 2009 - v1
    Checksum:i90A3150FBBF2083F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000922 Genomic DNA. Translation: ACJ35049.1.
    RefSeqiWP_012576178.1. NC_011567.1.
    YP_002317034.1. NC_011567.1.

    Genome annotation databases

    EnsemblBacteriaiACJ35049; ACJ35049; Aflv_2696.
    GeneIDi7038969.
    KEGGiafl:Aflv_2696.
    PATRICi20957388. VBIAnoFla45531_2779.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000922 Genomic DNA. Translation: ACJ35049.1 .
    RefSeqi WP_012576178.1. NC_011567.1.
    YP_002317034.1. NC_011567.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 491915.Aflv_2696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACJ35049 ; ACJ35049 ; Aflv_2696 .
    GeneIDi 7038969.
    KEGGi afl:Aflv_2696.
    PATRICi 20957388. VBIAnoFla45531_2779.

    Phylogenomic databases

    eggNOGi COG1005.
    HOGENOMi HOG000228276.
    KOi K00337.
    OMAi GAFRNFA.
    OrthoDBi EOG6B62B4.

    Enzyme and pathway databases

    BioCyci AFLA491915:GHEO-2785-MONOMER.

    Family and domain databases

    HAMAPi MF_01350. NDH1_NuoH.
    InterProi IPR001694. NADH_UbQ_OxRdtase_su1/FPO.
    IPR018086. NADH_UbQ_OxRdtase_su1_CS.
    [Graphical view ]
    PANTHERi PTHR11432. PTHR11432. 1 hit.
    Pfami PF00146. NADHdh. 1 hit.
    [Graphical view ]
    PROSITEi PS00668. COMPLEX1_ND1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
      Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
      Genome Biol. 9:R161.1-R161.16(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: DSM 21510 / WK1.

    Entry informationi

    Entry nameiNUOH_ANOFW
    AccessioniPrimary (citable) accession number: B7GME7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3