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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Anoxybacillus flavithermus (strain DSM 21510 / WK1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei579ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAFLA491915:G1GAW-511-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:Aflv_0425
OrganismiAnoxybacillus flavithermus (strain DSM 21510 / WK1)
Taxonomic identifieri491915 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeAnoxybacillus
Proteomesi
  • UP000000742 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10001991721 – 805Leucine--tRNA ligaseAdd BLAST805

Proteomic databases

PRIDEiB7GK53

Interactioni

Protein-protein interaction databases

STRINGi491915.Aflv_0425

Structurei

3D structure databases

ProteinModelPortaliB7GK53
SMRiB7GK53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 51"HIGH" regionAdd BLAST12
Motifi576 – 580"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C8T Bacteria
COG0495 LUCA
HOGENOMiHOG000200748
KOiK01869
OMAiTFMVLAP
OrthoDBiPOG091H01JZ

Family and domain databases

Gene3Di3.40.50.620, 2 hits
3.90.740.10, 1 hit
HAMAPiMF_00049_B Leu_tRNA_synth_B, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR002300 aa-tRNA-synth_Ia
IPR002302 Leu-tRNA-ligase
IPR025709 Leu_tRNA-synth_edit
IPR013155 M/V/L/I-tRNA-synth_anticd-bd
IPR015413 Methionyl/Leucyl_tRNA_Synth
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
IPR009008 Val/Leu/Ile-tRNA-synth_edit
PANTHERiPTHR43740 PTHR43740, 2 hits
PfamiView protein in Pfam
PF08264 Anticodon_1, 1 hit
PF00133 tRNA-synt_1, 1 hit
PF13603 tRNA-synt_1_2, 1 hit
PF09334 tRNA-synt_1g, 1 hit
PRINTSiPR00985 TRNASYNTHLEU
SUPFAMiSSF47323 SSF47323, 1 hit
SSF50677 SSF50677, 1 hit
TIGRFAMsiTIGR00396 leuS_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

B7GK53-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFNHREIEK KWQKYWEENK TFKTTEDDGK RKFYALDMFP YPSGAGLHVG
60 70 80 90 100
HPEGYTATDI LARMKRMQGY NVLHPMGWDA FGLPAEQYAL DTGNDPAEFT
110 120 130 140 150
EKNINNFRRQ IKSLGFSYDW DREVNTTDPN YYKWTQWIFL KLYEKGLAYM
160 170 180 190 200
DEVPVNWCPA LGTVLANEEV IDGKSERGGH PVIRKPMKQW MLRITAYADR
210 220 230 240 250
LLEDLEELDW PESIKEMQRN WIGRSEGANI HFQVDGHDET FTVFTTRPDT
260 270 280 290 300
LFGATYAVLA PEHPLVEKIT TPEQKEAVEA YLKQIQSKSD LERTDLAKEK
310 320 330 340 350
TGVFTGAYAI NPANGEKLPI WIADYVLMSY GTGAIMAVPA HDERDYEFAK
360 370 380 390 400
KFNLPIKQVV AGGDISKEAY TGDGEHINSD FLNGLNKEEA TKKMIEWLEA
410 420 430 440 450
NGKGEKKVSY RLRDWLFSRQ RYWGEPIPII HWEDGTMTPV PEEELPLVLP
460 470 480 490 500
KTDEIKPSGT GESPLANIEE WVSVVDPKTG KKGRRETNTM PQWAGSCWYY
510 520 530 540 550
LRYIDPHNDK QLADPEKLEK WLPVDIYIGG AEHAVLHLLY ARFWHKFLYD
560 570 580 590 600
IGVVPTKEPF QKLFNQGMIL GENNEKMSKS KGNVVNPDDI VESHGADTLR
610 620 630 640 650
LYEMFMGPLE ASIAWSTKGL DGARRFLDRV WRLFVEENGE LNPKIVDNPE
660 670 680 690 700
TDTLERVYHQ TVKKVTEDYE ALRFNTAISQ LMVFINEAYK APILPKAYME
710 720 730 740 750
GFVKLLSPVC PHIAEELWEK LGYSNTIAYE AWPAYDEAKL VEDEVEIVIQ
760 770 780 790 800
VNGKVRAKLH VPADATKEQL EQLAMEDEKI KEQIEGKTVR KVIAVPGKLV

NIVAN
Length:805
Mass (Da):92,398
Last modified:February 10, 2009 - v1
Checksum:iA208849E5C1DC81C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000922 Genomic DNA Translation: ACJ32809.1
RefSeqiWP_012574132.1, NC_011567.1

Genome annotation databases

EnsemblBacteriaiACJ32809; ACJ32809; Aflv_0425
KEGGiafl:Aflv_0425
PATRICifig|491915.6.peg.435

Similar proteinsi

Entry informationi

Entry nameiSYL_ANOFW
AccessioniPrimary (citable) accession number: B7GK53
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: May 23, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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