Skip Header

Contribute Send feedback
Read comments (?) or add your own

B7GJR4 (MTLD_ANOFW) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 21. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mannitol-1-phosphate 5-dehydrogenase
EC=1.1.1.17
Gene names
Name:mtlD
Ordered Locus Names:Aflv_1562
OrganismAnoxybacillus flavithermus (strain DSM 21510 / WK1) [Complete proteome] [HAMAP]
Taxonomic identifier491915 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacillales › Bacillaceae › Anoxybacillus

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196

Sequence similarities

Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Molecular functioncoenzyme binding

Inferred from electronic annotation. Source: InterPro

mannitol-1-phosphate 5-dehydrogenase activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196
PRO_1000118653

Regions

Nucleotide binding3 – 1412NAD By similarity

Sequences

Sequence LengthMass (Da)Tools
B7GJR4 [UniParc].

Last modified February 10, 2009. Version 1.
Checksum: 6E522D07F5A60B21

FASTA37942,655
        10         20         30         40         50         60 
MLAVHFGAGN IGRGFIGSLL SQSRYNVVFV DVNEKIVQAL QQKGQYEVII AGETTQTQVV 

        70         80         90        100        110        120 
RNVSALHSQH QQNEIIDQIA RADLVTTAVG PNILPLISQT IAEGLKKRLT DRPVHIIACE 

       130        140        150        160        170        180 
NMIGGSEHLK TYVWEHLSEQ EQTSLEDKCG FLNCAVDRIV PNQTHEDPLT VVVEPFFEWV 

       190        200        210        220        230        240 
IETKEVIGNI PHIIGAHFVD DLQPYIERKL FTVNTGHALV AYLGYRKKYE TIRQAMEDQD 

       250        260        270        280        290        300 
ILADVTNALR ESGRVLVHQY GWNEAEHQAY IEKIVQRFIN PSMTDEVTRV ARSPIRKLGP 

       310        320        330        340        350        360 
NDRLIRPAMK YYECFGEVPA SLAKGIAALL LFDYEGDAEA VQLQQTIKES GVEGALEKYA 

       370 
KLPSNHPIVV EVKKQMLYM

« Hide

References

[1]"Encapsulated in silica: genome, proteome and physiology of the thermophilic bacterium Anoxybacillus flavithermus WK1."
Saw J.H., Mountain B.W., Feng L., Omelchenko M.V., Hou S., Saito J.A., Stott M.B., Li D., Zhao G., Wu J., Galperin M.Y., Koonin E.V., Makarova K.S., Wolf Y.I., Rigden D.J., Dunfield P.F., Wang L., Alam M.
Genome Biol. 9:R161.1-R161.16(2008) [PubMed: 19014707] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: DSM 21510 / WK1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000922 Genomic DNA. Translation: ACJ33927.1.
RefSeqYP_002315912.1. NC_011567.1.

3D structure databases

ProteinModelPortalB7GJR4.
ModBaseSearch...

Protein-protein interaction databases

STRINGB7GJR4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID7037817.
GenomeReviewsGene locus Aflv_1562 in contig CP000922_GR.
KEGGafl:Aflv_1562.
PATRIC20955005. VBIAnoFla45531_1611.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG568825.
ProtClustDBPRK02318.

Family and domain databases

HAMAPMF_00196. Mannitol_dehydrog.
[Tree]
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR013328. DH_multihelical.
IPR023028. Mannitol_1_phos_5_DH.
IPR000669. Mannitol_DH.
IPR013118. Mannitol_DH_C.
IPR013131. Mannitol_DH_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
G3DSA:1.10.1040.10. Opine_DH. 1 hit.
KOK00009.
PfamPF01232. Mannitol_dh. 1 hit.
PF08125. Mannitol_dh_C. 1 hit.
[Graphical view]
PRINTSPR00084. MTLDHDRGNASE.
SUPFAMSSF48179. 6DGDH_C_like. 1 hit.
PROSITEPS00974. MANNITOL_DHGENASE. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMTLD_ANOFW
AccessionPrimary (citable) accession number: B7GJR4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: February 10, 2009
Last modified: January 25, 2012
This is version 21 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents